Abstract To study how adult hippocampal neurogenesis might originate from the proliferation of stem or progenitor cells in vivo, we have used transgenic mice expressing green fluorescent protein (GFP) under nestin promoter to identify these cells. Having described an astrocyte‐like type 1 cell with low proliferative activity, a characteristic morphology, vascular end feet, and passive electrophysiological properties, focused here on large population nestin‐GFP‐expressing 2 cells, which lack...

Abstract In adult hippocampal neurogenesis, new neurons appear to originate from a cell with astrocytic properties expressing glial fibrillary acidic protein (GFAP). Also, astrocytes are generated in the dentate gyrus. Whereas putative astrocyte‐like progenitor cells consistently S‐100β‐negative, many S‐100β‐positive. Thus, it is unclear whether GFAP‐positive general sense or rather neural certain characteristics. We therefore investigated development of GFAP‐expressing context neurogenesis....

Telling Sandpaper from Satin Pacinian corpuscles are mechano-receptors tuned to detect high-frequency, low-amplitude, signals. Found in human palm and fingertips, they useful for discrimination of rough smooth textures, a sensitivity seemingly amplified by the ridges fingerprints. Wende et al. (p. 1373 , published online 16 February) identified mutation humans that disrupts this texture, but leaves other facets touch, such as tactile spatial acuity, intact.

Gait dysfunction is a common and relevant symptom in multiple sclerosis (MS). This study aimed to profile gait pathology gait-impaired patients with MS using comprehensive 3D analysis clinical walking tests. Thirty-seven walked on the treadmill at their individual, sustainable speed while 20 healthy control subjects all different patient's paces, allowing for comparisons independent of velocity. Kinematic revealed pronounced restrictions knee ankle joint excursion, increased variability...

More than 90% of clinical-trial compounds fail to demonstrate sufficient efficacy and safety. To help alleviate this issue, systematic literature review meta-analysis (SLR), which synthesize current evidence for a research question, can be applied preclinical identify the most promising therapeutics. However, these methods remain time-consuming labor-intensive. Here, we introduce an economic formula estimate expense SLR academic institutions pharmaceutical companies.We manual effort involved...

Distinct types of relay neurons in the hindbrain process somatosensory or viscerosensory information. How choose between these two fates is unclear. We show here that homeobox gene Lbx1 essential for imposing a fate on hindbrain. In mutant mice, are specified at expense neurons. Thus expression distinguishes

The Olig3 gene encodes a bHLH factor that is expressed in the ventricular zone of dorsal alar plate hindbrain. We found Olig3+ progenitor domain encompassed subdomains co-expressed Math1, Ngn1, Mash1 and Ptf1a. cells give rise to neuronal types we denote as class A neurons. used genetic lineage tracing demonstrate neurons contribute nucleus solitary tract precerebellar nuclei. fate was not correctly determined mutant mice. As consequence, did form, nuclei, such inferior olivary nucleus, were...

Background: The institutions that comprise the Clinical and Translational Science Award (CTSA) consortium National Center for Advancing Sciences continue to explore develop community-engaged research strategies study role of community academic partnerships in advancing science engagement.

No AccessJournal of UrologyAdult Urology1 Sep 2010The Effect Botulinum Toxin Type A on Overactive Bladder Symptoms in Patients With Multiple Sclerosis: Pilot Study Ulrich Mehnert, Jan Birzele, Katja Reuter, and Brigitte Schurch MehnertUlrich Mehnert More articles by this author , BirzeleJan Birzele ReuterKatja Reuter SchurchBrigitte Financial interest and/or other relationship with Allergan, Astellas Pfizer. View All Author Informationhttps://doi.org/10.1016/j.juro.2010.05.035AboutFull...

Background: Prolonged-release fampridine (PR-fampridine, 4-aminopyridine) increases walking speed in the timed 25-foot walk test (T25FW) some patients (timed-walk responders) with multiple sclerosis (MS). Objective: To explore effects of PR-fampridine on different aspects function and to identify associated gait modifications subjects MS. Methods: In this prospective, randomized, placebo-controlled, double-blind, phase II study (FAMPKIN; clinicaltrials.gov , NCT01576354), received a 6-week...

Public health organizations have begun to use social media increase awareness of harm and positively improve behavior. Little is known about effective strategies disseminate education messages digitally ultimately achieve optimal audience engagement.This study aims assess the difference in engagement with identical antismoking on three sites (Twitter, Facebook, Instagram) a referring link tobacco prevention website cited these messages. We hypothesized that might not receive same user media,...

Cognitive impairment is as an important feature of Multiple Sclerosis (MS), and might be even more relevant to patients than mobility restrictions. Compared the multitude studies investigating memory deficits or basic cognitive slowing, executive dysfunction a rarely studied domain in MS, its neural correlates remain largely unexplored. Even rarer are topological on specific functions MS. Here we used several structural MRI parameters - including cortical thinning T2 lesion load investigate...

<h3>Objective:</h3> To expand upon the limited knowledge of long-term effects prolonged-release (PR) fampridine in patients with multiple sclerosis (PwMS) regarding safety, walking improvements, and changes drug responsiveness. <h3>Methods:</h3> Fifty-three PwMS who completed FAMPKIN core study were included this extension trial. Drug efficacy was assessed an open-label randomized double-blind, placebo-controlled design regular baseline assessments over a period 2 years using Timed 25-Foot...

Recent studies suggest that cortical lesions in multiple sclerosis (MS) substantially contribute to clinical disease severity. The present study aimed at investigating clinical, neuroanatomical, and cognitive correlates of these with a novel approach, i.e. by comparing two samples relapsing-remitting (RRMS) patients, one group the other without lesions.High-resolution structural MRI was acquired from 42 RRMS patients 43 controls (HC). patient dichotomized based on presence versus absence...

During the COVID-19 pandemic, much communication occurred online, through social media. This study aimed to provide patient perspective data on how pandemic impacted people with rheumatic and musculoskeletal diseases (RMDs), using Twitter-based patient-generated health (PGHD).A convenience sample of Twitter messages in English posted by RMDs was extracted between 1 March 12 July 2020 examined thematic analysis. Included were that mentioned keywords hashtags related both (or SARS-CoV-2)...

Objective: Little is known about the effects of distant healing in chronically ill patients, population most likely to see a healer practice. This study investigated whether as found normal practice with patients representative those seeking treatment from healers changes patients' quality life substantially. Method: Randomized, waiting-list controlled (anonymous, amulet, and allowing for personal contact) patients. Outcome measure: Patient-reported expressed by sum all MOS SF-36 health...

Social networks such as Twitter offer the clinical research community a novel opportunity for engaging potential study participants based on user activity data. However, availability of public social media data has led to new ethical challenges about respecting privacy and appropriateness monitoring trial recruitment. Researchers have voiced need involving users' perspectives in development norms regulations.This examined attitudes level concern among users nonusers using their conversations...

Abstract Falls are common in patients with neurological disorders and a primary cause of injuries. Nonetheless, fall-associated gait characteristics poorly understood these patients. Objective, quantitative analysis is an important tool to identify the principal fall-related motor advance fall prevention disorders. Fall incidence was assessed 60 subjects different Patients underwent comprehensive set functional assessments including instrumented analysis, computerized postural clinical...

Participant recruitment remains a barrier to conducting clinical research. The disabling nature of stroke, which often includes functional and cognitive impairments, the acute stage illness at patients are appropriate for many trials make recruiting particularly complex challenging. In addition, people aged 65 years older, most stroke survivors, have been identified as group that is difficult reach commonly underrepresented in health research, trials. Digital media may provide effective...