A5005182891- Folate and B Vitamins Research
- Multiple Sclerosis Research Studies
- Acute Lymphoblastic Leukemia research
- Wound Healing and Treatments
- Amyotrophic Lateral Sclerosis Research
- Metabolism and Genetic Disorders
- T-cell and Retrovirus Studies
- Dermatologic Treatments and Research
- Esophageal and GI Pathology
- Burn Injury Management and Outcomes
- Neurological diseases and metabolism
- HIV-related health complications and treatments
- Iron Metabolism and Disorders
- Rheumatoid Arthritis Research and Therapies
- Alzheimer's disease research and treatments
- Neurogenetic and Muscular Disorders Research
- Gender Studies in Language
- Corneal Surgery and Treatments
- Phagocytosis and Immune Regulation
- Blood properties and coagulation
- Autoimmune and Inflammatory Disorders Research
- Trace Elements in Health
- Fluoride Effects and Removal
- Amino Acid Enzymes and Metabolism
- Neonatal skin health care
University of Zurich
2009-2025
University Children's Hospital Zurich
2024-2025
Biogen (Switzerland)
2016
University Hospital of Zurich
2010-2014
<i>Background:</i> Increased plasma homocysteine levels have been described as an independent risk factor for Alzheimer’s disease (AD), but the underlying pathophysiology is unclear. <i>Objective:</i> This single-center, cross-sectional, correlational study analyzed metabolism in 60 AD patients and control subjects. <i>Methods:</i> Fasting of vitamin B<sub>12</sub>, folate well cerebrospinal fluid (CSF) derivates,...
Background: Prolonged-release fampridine (PR-fampridine, 4-aminopyridine) increases walking speed in the timed 25-foot walk test (T25FW) some patients (timed-walk responders) with multiple sclerosis (MS). Objective: To explore effects of PR-fampridine on different aspects function and to identify associated gait modifications subjects MS. Methods: In this prospective, randomized, placebo-controlled, double-blind, phase II study (FAMPKIN; clinicaltrials.gov , NCT01576354), received a 6-week...
Abstract Limited donor sites and poor long-term outcomes with standard treatment for large skin defects remain a huge problem. An autologous, bilayered, laboratory-grown substitute (denovoSkin) was developed to overcome this problem has shown be safe in 10 pediatric patients Phase I clinical trial after transplantation. The goal of article report on 48-month results. participants the phase were followed up at yearly visits 5 years Safety parameters, including occurrence adverse events,...
Hyperhomocysteinemia is associated with Alzheimer's disease (AD). The causality of this association controversial. In study we tested the effect a hyperhomocysteinemia-inducing diet in ArcAβ transgenic AD mouse model. At 14 months age, yielded higher plasma homocysteine levels mice compared wild-type mice. Levels 5-methyltetrahydrofolate (5-MTHF) 14-month-old on were lower than folate derivate 5-MTHF serves as cofactor metabolism. Oxidative stress, which occurs course mice, consumes 5-MTHF....
Abstract Disturbances in the levels of one-carbon (1C) metabolism metabolites have been associated with a wide variety neuropsychiatric diseases. Cerebrospinal fluid (CSF) homocysteine (Hcy) and other 1C metabolites, nor their interrelatedness putative determinants, studied extensively healthy population. Plasma CSF samples from 100 individuals free diseases were analyzed (55 male, 45 female; age 50±17 years). In blood, we measured plasma Hcy, serum folate vitamin B12. CSF, total...
Hyperhomocysteinemia is a risk factor for Alzheimer's disease (AD). Both homocysteine (Hcy) and amyloid β (Aβ), which accumulates in the brain of AD patients, bind copper. Aim this study was to test hypothesis that association Hcy results from molecular interaction between Aβ mediated by We established microtiter plate format thioflavin T aggregation assay monitor Aβ42 fibrillization. Copper (5 μM) completely prevented Homocysteine absence copper did not impact fibrillization, but...
Hyperhomocysteinemia is a risk factor for neurodegeneration, and binding of copper by homocysteine putative underlying mechanism. As mutations the copper-dependent superoxide dismutase are observed in familial ALS, we tested whether genetic variants with influence on metabolism associated ALS. We compared frequency seven genes involved 162 patients sporadic ALS controls who did not significantly differ age (t = 1.27, p 0.205) gender (χ2 2.48, 0.115) using binary regression analysis. Results...
For pediatric patients with full-thickness burns, achieving adequate dermal regeneration is essential to prevent inelastic scars that may hinder growth. Traditional autologous split-thickness skin grafts alone often fail restore the layer adequately. This study evaluates long-term effect of using a NovoSorb® Biodegradable Temporizing Matrix (BTM) as scaffold in four patients, promoting formation before autografting. Pediatric burn treated at University Children’s Hospital Zurich between 2020...