- Air Quality and Health Impacts
- Occupational exposure and asthma
- Advanced Statistical Process Monitoring
- Occupational and environmental lung diseases
- Occupational Health and Safety Research
- Influenza Virus Research Studies
- Advanced Statistical Methods and Models
- Data-Driven Disease Surveillance
- Noise Effects and Management
- Indoor Air Quality and Microbial Exposure
- Retinoids in leukemia and cellular processes
- Antioxidant Activity and Oxidative Stress
- Statistical Methods and Inference
- COVID-19 epidemiological studies
- Scientific Measurement and Uncertainty Evaluation
- Carcinogens and Genotoxicity Assessment
- Growth Hormone and Insulin-like Growth Factors
- Skin Protection and Aging
- Climate Change and Health Impacts
- Per- and polyfluoroalkyl substances research
- Asthma and respiratory diseases
- Pituitary Gland Disorders and Treatments
- Sleep and Work-Related Fatigue
- Bayesian Methods and Mixture Models
- Contact Dermatitis and Allergies
Sahlgrenska University Hospital
2015-2024
University of Gothenburg
2015-2024
Statens Serum Institut
2013
AstraZeneca (Singapore)
2013
Statistics Sweden
2004-2010
Science for Life Laboratory
2006
Umeå University
2005
Statistical Research (United States)
2004
Linköping University
1996-2003
Sundsvall Municipality
2001
The Swedish National Inpatient Register (IPR), also called the Hospital Discharge Register, is a principal source of data for numerous research projects. IPR part Patient Register. was launched in 1964 (psychiatric diagnoses from 1973) but complete coverage did not begin until 1987. Currently, more than 99% all somatic (including surgery) and psychiatric hospital discharges are registered IPR. A previous validation by Board Health Welfare showed that 85-95% valid. current paper describes...
The risk for sight-threatening retinopathy of prematurity is predicted by using gestational age and/or weight at birth. All infants below a threshold undergo serial ophthalmologic examinations identification those who would benefit from treatment (approximately 10%). We hypothesized that factoring in postnatal gain could identify children more specifically and earlier.Weekly weights birth to postmenstrual week 36 were retrospectively entered into surveillance system gave an alarm when the...
Abstract Context: Craniopharyngiomas (CPs) in adults have been associated with excess mortality. Objective: The aim of the study was to investigate mortality and morbidity patients childhood-onset adult-onset CP. Methods: Patients CP were identified followed Swedish national health registries, 1987 through 2011. inclusion criteria for diagnosis internally validated against patient records 28% population. Settings: This a nationwide population-based study. Patients: A total 307 (151 men 156...
Patients with hypopituitarism of various etiologies have excess mortality. The mortality in patients nonfunctioning pituitary adenoma (NFPA), regardless function, is less well studied.Our aim was to investigate NFPA and examine whether age at diagnosis, gender, tumor treatments, or hormonal deficiencies influence the outcome.NFPA were identified followed up nationwide health registries Sweden, 1987-2011. criteria for identification tested validated a subpopulation patients.This nationwide,...
We have constructed a reference model to facilitate comparison of serum IGF-I values among children, and thereby improve the value measurements for diagnosis. The data set consists measured in 969 samples from 468 healthy children adolescents (232 males, 236 females; ages, 1.1–18.3 yr). One sample per child was used model, each being selected so as provide sufficient observations stage puberty. not were validate data. log transformed, multiple regression analysis model-building process. best...
Objectives The study investigated the relationship between shiftwork and mortality, both total mortality cause-specific from coronary heart disease (CHD), stroke, diabetes. Methods cohort consisted of 2354 shiftworkers 3088 dayworkers in two pulp paper manufacturing plants. was monitored 1 January 1952 to 31 December 2001 by linkage national Cause Death Register. Groups workers defined different durations exposure were compared with calculating standardized relative rates (SRR). Results due...
BackgroundThere are few studies on predictors of smoking cessation in general populations. We studied the rate relation to several potential predictors, with special focus respiratory and cardiovascular disease.MethodsSmokers (n = 4636) from seven centres Northern Europe, born between 1945 1973, who answered a questionnaire 1999–2001 (the RHINE study) were followed up new 2010–2012. Altogether 2564 provided complete data smoking. Cox regression analyses performed calculate hazard ratios...
Perfluorinated substances (PFAS) are chemicals with endocrine disruptive properties that may interfere the female reproductive system. However, few studies have explored association between benign gynecological diseases and high PFAS exposure.The aim of this study was to investigate possible associations exposure subsequent diagnosis polycystic ovarian syndrome (PCOS), uterine leiomyoma (fibroids), endometriosis in a cohort exposed through drinking water.In 2013, levels (with sum above...
Objectives:In a large population-based study among adults in northern Europe the relation between occupational exposure and new-onset asthma was studied.
Objectives We aimed to update an asthmagen job exposure matrix (JEM) developed in the late 1990s. Main reasons were: number of suspected and recognised asthmagens has since tripled; understanding aetiological role irritants asthma methodological insights application JEMs have emerged period. Methods For each agent new occupational asthma-specific JEM (OAsJEM), a working group three experts out eight evaluated for International Standard Classification Occupations, 1988 (ISCO-88) code into...
Five thousand one hundred and forty questionnaires concerning leg ulcers were sent to a randomly selected population aged 65 years older in Gothenburg April 1989. The response rate was 89%. Ninety-seven individuals answered affirmatively, that they had ulcers, which corresponds prevalence of 2.15 +/- 0.42 per cent. These 97 the same number controls asked come for medical examination with tests peripheral circulation an interview. Seventy-five (of 97) examined. Thirty-five or foot caused by...
The aim of the present study was to investigate whether repeated peak exposure (gassings) sulphur dioxide (SO 2 ) and other irritant gases increases risk new-onset asthma. A questionnaire sent 4,112 sulphite workers, whom 1,919 completed 396 short-form questionnaire, which out as a last reminder. sample 130 nonrespondents telephone interview using questionnaire. incidence adult-onset, physician-diagnosed asthma during employment duration analysed in relation SO gassings giving rise...
Environmental noise is a growing and well recognized health problem. However, in many cases people are exposed not to single source—for example, road, railway, or aircraft noise—but combination of exposures there only limited knowledge the effects on exposure combined sources. A socio-acoustic survey among 1953 persons aged 18–75 years was conducted residential areas railway road traffic with sound levels ranging from LAeq,24h 45–72dB municipality east Gothenburg, Sweden. The objectives were...
Objective Hypopituitarism has been associated with increased mortality. The excess mortality may be due to untreated growth hormone (GH) deficiency but also various underlying disorders. We therefore analysed in patients only one disorder, non-functioning pituitary adenoma (NFPA), and without GH replacement therapy (GHRT). Design method Patients NFPA the western region of Sweden, 1997–2011, were identified through National Patient Registry cross-referenced several Health Registries. All...
Objectives The aims were to investigate whether occupational noise increased the risk for coronary heart disease (CHD) and stroke elucidate interactions with stressful working conditions in a cohort of Swedish men. Design This is prospective study on CHD men followed until death, hospital discharge or 75 years age, using national registers cause death discharges. Baseline data occupation from 1974 1977 used classification levels job demand-control. Cox regression was analyse HRs stroke....
Asthma is a prevalent chronic disease and occupation contributes to approximately 15 % of cases among adults. However, there are still few studies on risk factors for work-exacerbated asthma. The current study investigated the association between asthma exacerbations occupational exposures. comprised all currently working adults (n = 1356) who reported ever in prior population-based cohorts. All subjects completed questionnaire about exposures, occupations Exposure high low molecular weight...
Objectives The aim of this study was to estimate the prevalence respiratory symptoms and physician-diagnosed asthma assess impact current occupational exposure. Design Cross-sectional analyses self-reported health association with exposure in a random sample general population Telemark County, Norway. Settings In 2013, self-administered questionnaire mailed population, aged 16–50, Telemark, overall response rate 33%, comprising 16 099 responders. Outcome measures for asthma, OR groups...
To study respiratory effects of exposure to soft paper dust exposure, a relationship that is rarely studied. Soft tissue mill workers at Swedish were investigated using questionnaire and lung function atopy screening. Spirometry without bronchodilation was performed with dry wedge spirometer, forced vital capacity (FVC) expiratory volume in 1 s (FEV1) obtained expressed as percent predicted. Exposure assessed from historical stationary personal measurements total dust, addition information...
As many other countries around the world, Sweden is currently facing an urgent need for new teachers. Creating sound work environments that can retain beginning teachers in profession—as well as attract ones—is one way to address problem. In order accomplish this task, research must be able reflect complex nature of environments. present study, a cluster analysis four job demands and five resources among 328 Swedish their first year teaching, resulted typical situations: advantageous...
The aims of the present study were to determine whether exposure high peaks ozone resulted in an increased prevalence asthma or respiratory symptoms among bleachery workers and nitric oxide (NO) was elevated exhaled air these workers. Bleachery (n=228) from three Swedish pulp mills who had been exposed ozone, together with 63 unexposed control subjects, investigated by means spirometry, Phadiatop®, nasal NO answers a questionnaire concerning exposure. Exposure peak that gave rise defined as...
Abstract Methods for online turning point detection in business cycles are discussed. The statistical properties of three likelihood-based methods compared. One is based on a Hidden Markov Model, another includes non-parametric estimation procedure and the third combines features other two. illustrated by monitoring period Swedish industrial production. Evaluation measures that reflect timeliness used. effects smoothing, seasonal variation, autoregression multivariate issues timely
To study the relationship between exposure to airborne particles in a pulp and paper mill markers of inflammation coagulation blood.Personal sampling inhalable dust was performed for 72 subjects working Swedish mill. Stationary measurements were used concentrations total dust, respirable PM10 PM2.5, particle surface area number concentrations. Markers inflammation, interleukins (IL-1b, IL-6, IL-8, IL-10), C-reactive protein (CRP), serum amyloid A (SAA), fibrinogen factor VIII, von...