A5031922274- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Air Quality and Health Impacts
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Allergic Rhinitis and Sensitization
- Indoor Air Quality and Microbial Exposure
- Noise Effects and Management
- Inhalation and Respiratory Drug Delivery
- Smoking Behavior and Cessation
- Occupational exposure and asthma
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Sleep and related disorders
- IL-33, ST2, and ILC Pathways
- Dermatology and Skin Diseases
- Physical Activity and Health
- Eosinophilic Esophagitis
- Air Quality Monitoring and Forecasting
- Obstructive Sleep Apnea Research
- Gastroesophageal reflux and treatments
- Climate Change and Health Impacts
- Delphi Technique in Research
- Health, psychology, and well-being
- Birth, Development, and Health
Tartu University Hospital
2016-2025
University of Tartu
2006-2020
Haukeland University Hospital
2004-2012
Uppsala University
2004
National University Hospital of Iceland
2004
Sahlgrenska University Hospital
2004
Uppsala University Hospital
2002
Linköping University Hospital
1999
<b><i>Background:</i></b> This study is aimed at providing a real-world evaluation of the economic cost persistent asthma among European adults according to degree disease control [as defined by 2006 Global Initiative for Asthma (GINA) guidelines]. <b><i>Methods:</i></b> A prevalence-based cost-of-illness was carried out on 462 patients aged 30–54 years with (according 2002 GINA definition), who were identified in general population samples...
Several studies have identified obesity as a risk factor for asthma in both children and adults. An increased prevalence of subjects with gastro-oesophageal reflux (GOR) obstructive sleep apnoea syndrome has also been reported. The aim this investigation was to study obesity, nocturnal GOR snoring independent factors onset respiratory symptoms Nordic population. In 5–10 yr follow-up the European Community Respiratory Health Survey Iceland, Norway, Denmark, Sweden Estonia, postal...
Rationale: Menopause is associated with changes in sex hormones, which affect immunity, inflammation, and osteoporosis may impair lung function. Lung function decline has not previously been investigated relation to menopause.Objectives: To study whether decline, assessed by FVC FEV1, accelerated women who undergo menopause.Methods: The population-based longitudinal European Community Respiratory Health Survey provided serum samples, spirometry, questionnaire data about respiratory...
Mothers' smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers' may have a similar effect, and biological plausibility fathers' adolescence influence offspring's health through transmittable epigenetic changes sperm precursor cells. We evaluated the three-generation associations of tobacco with asthma. Between 2010 2013, at European Community Respiratory Health Survey III clinical interview, 2233 mothers 1964 fathers from 26 centres...
Rationale: The Global Burden of Disease program identified smoking and ambient household air pollution as the main drivers death disability from chronic obstructive pulmonary disease (COPD). Objectives: To estimate attributable risk airflow obstruction (CAO), a quantifiable characteristic COPD, due to several factors. Methods: Obstructive Lung study is cross-sectional adults, aged ≥40, in globally distributed sample 41 urban rural sites. Based on data 28,459 participants, we estimated...
Associations between measured specific VOC reported to be associated with dampness and microbial growth in dwellings asthma, lung function were investigated 159 adults (one adult/home) from three North European cities (Reykjavik, Uppsala Tartu). Spirometry was performed forced vital capacity (FVC), expiratory volume 1 s (FEV1) FEV1/FVC measured. Among participants, 58% females, 24.5% atopics, 25.8% current smokers 41% or mold at home. Dimethyl disulphide (p = 0.004), ethyl isobutyrate 0.021)...
Objectives To explore the relationship between physical activity over a 10-year period and current symptoms of insomnia, daytime sleepiness estimated sleep duration in adults aged 39–67. Design Population-based, multicentre cohort study. Setting 21 centres nine European countries. Methods Included were 4339 participants third follow-up to Community Respiratory Health Survey (ECRHS III), who answered questions on at baseline II) activity, insomnia symptoms, III). Participants reported that...
The impact of active smoking, passive and obesity on habitual snoring in the population is mainly unknown. We aimed to study relationship with tobacco smoking a population-based sample. A total 15,555 21,802 (71%) randomly selected men women aged 25–54 years from Iceland, Estonia, Denmark, Norway, Sweden answered postal questionnaire. Habitual snoring, defined as loud disturbing at least 3 nights week, was more prevalent among current smokers (24.0%, p < 0.0001) ex-smokers (20.3%, than...
Background: Fluticasone furoate is a new enhanced‐affinity glucocorticoid with unique combination of pharmacodynamic and physicochemical properties suitable for topical activity. Methods: In this multicentre, randomized, double‐blind, placebo‐controlled, parallel‐group study, patients [adults adolescents ≥12 years age seasonal allergic rhinitis (SAR)] received once‐daily (od) treatment 2 weeks either fluticasone nasal spray 110 μg ( n = 141) or placebo 144) administered in unique,...
Background: Few data are available on the asthma burden in general population. We evaluated level and factors associated with Europe. Methods: In 1999–2002, 1152 adult asthmatics were identified European Community Respiratory Health Survey (ECRHS)‐II socio‐economic (reduced activity days hospital services utilization past 12 months) was assessed. Results: The a light (only few reduced days) 13.2% (95% CI: 11.4–15.3%), whereas those heavy (many and/or utilization) 14.0% 12.1–16.1%). strongly...
Selection bias is a systematic error in epidemiologic studies that may seriously distort true measures of associations between exposure and disease. Observational are highly susceptible to selection bias, researchers should therefore always examine what extent be present their material characterizes the material. In study we examined long-term participation consequences loss follow-up Respiratory Health Northern Europe (RHINE), Italian centers European Community Survey (I-ECRHS), Study on...
Background: Whereas it is generally accepted that maternal environment plays a key role in child health, emerging evidence suggests paternal before conception also impacts health. We aimed to investigate the association between children's asthma risk and parental smoking welding exposures prior conception. Methods: In longitudinal, multi-country study, parents of 24 168 offspring aged 2–51 years provided information on their life-course habits, occupational exposure metal fumes, offspring's...
Occupational exposures have been associated with an increased risk of COPD. However, few studies related objectively assessed occupational to prospectively incidence COPD, using postbronchodilator lung function tests. Our objective was examine the effect on COPD in European Community Respiratory Health Survey.General population samples aged 20-44 were randomly selected 1991-1993 and followed up 20 years later (2010-2012). Spirometry performed at baseline follow-up, incident defined a lower...
BackgroundThere are few studies on predictors of smoking cessation in general populations. We studied the rate relation to several potential predictors, with special focus respiratory and cardiovascular disease.MethodsSmokers (n = 4636) from seven centres Northern Europe, born between 1945 1973, who answered a questionnaire 1999–2001 (the RHINE study) were followed up new 2010–2012. Altogether 2564 provided complete data smoking. Cox regression analyses performed calculate hazard ratios...
Previous studies have reported an association between weight increase and excess lung function decline in young adults followed for short periods. We aimed to estimate trajectories during adulthood from 20-year change profiles using data the population-based European Community Respiratory Health Survey (ECRHS).
Background Smoking is the main risk factor for most of leading causes death. Cessation single important step that smokers can take to improve their health. With aim informing policy makers about decisions on future tobacco control strategies, we estimated time and age trends in smoking cessation Europe between 1980 2010. Methods Data history 50,228 lifetime from 17 European countries were obtained six large population-based studies included Ageing Lungs Cohorts (ALEC) consortium. rates...
The aim of the present investigation was to study changes and determinants for in active passive smoking. included 9,053 adults from 14 countries that participated European Community Respiratory Health Survey II. mean follow-up period 8.8 yrs. Change prevalence smoking expressed as absolute net change (95% confidence interval) standardised a 10-yr period. Determinants were analysed results adjusted hazard risk ratio (HRR) or odds (OR). declined by 5.9% (5.1–6.8) exposure nonsmokers 18.4%...
Objectives:In a large population-based study among adults in northern Europe the relation between occupational exposure and new-onset asthma was studied.
The early life environment appears to have a persistent impact on asthma risk. We hypothesize that environmental factors related rural mediate lower prevalence in populations, and aimed investigate an urban-rural gradient, assessed by place of upbringing, for asthma. population-based Respiratory Health In Northern Europe (RHINE) study includes subjects from Denmark, Norway, Sweden, Iceland Estonia born 1945-1973. present analysis encompasses questionnaire data 11,123 RHINE subjects. Six...
Cross-sectional studies have reported a lower prevalence of sensitization in older adults, but few longitudinal examined whether this is an aging or year-of-birth cohort effect.We sought to assess changes and total IgE levels European adults as they aged over 20-year period.Levels serum specific common aeroallergens (house dust mite, cat, grass) were measured 3206 from 25 centers the Community Respiratory Health Survey on 3 occasions 20 years. Changes analyzed by using regression analysis...