A5061309796- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Asthma and respiratory diseases
- Kruppel-like factors research
- Respiratory and Cough-Related Research
- Psychiatric care and mental health services
- Schizophrenia research and treatment
- Platelet Disorders and Treatments
- Dementia and Cognitive Impairment Research
- Neurological Complications and Syndromes
- Cardiac Arrest and Resuscitation
- Health, Medicine and Society
- Immune cells in cancer
- Mesenchymal stem cell research
- Breast Implant and Reconstruction
- Multiple Myeloma Research and Treatments
- Allergic Rhinitis and Sensitization
- Insect Pheromone Research and Control
- Healthcare Technology and Patient Monitoring
- Traumatic Brain Injury Research
- Vascular Malformations and Hemangiomas
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Migraine and Headache Studies
Policlinico San Matteo Fondazione
1999-2024
Istituti di Ricovero e Cura a Carattere Scientifico
1999-2024
Foundation Center
2022
University of L'Aquila
2006-2013
University of Pavia
1999-2007
IRCCS Policlinico San Donato
2003
In patients with atrial fibrillation (AF) undergoing radiofrequency (RF) electrical disconnection of multiple pulmonary veins (PVs), the incidence late conduction recurrences has not been systematically determined.Using a prospectively designed, multistep approach, we aimed at assessing correlation between acute achievement and chronic maintenance block across RF lesions disconnecting distal tract PV in 43 (52.3+/-8.2 years) AF. Forty-one left superior (LS), 42 right (RS), 25 inferior (LI),...
Purpose In the WHO diagnostic classification, prefibrotic myelofibrosis (pre-MF) is included in category of primary (PMF). However, strong evidence for this position lacking. Patients and Methods We investigated whether pre-MF may be aligned along a clinical biological continuum 683 consecutive patients who received diagnosis PMF. Results As compared with PMF-fibrotic type, (132 cases) showed female dominance, younger age, higher hemoglobin, platelet count, lower white blood cell smaller...
There are few data on the outcomes of cardiac arrest (CA) victims when defibrillation capability broad rural and urban territories is fully operated by volunteers laypersons.In this study, we investigated whether a programme based diffuse deployment automated external defibrillators (AEDs) 2186 trained laypersons across County Brescia, Italy (area: 4826 km(2); population: 1 112 628), would safely effectively impact current survival among out-of-hospital CA. Forty-nine AEDs were added to...
We previously published that in patients with infantile hemangioma (IH) at the onset (T0) colony forming unit-fibroblasts (CFU-Fs) are present vitro cultures from PB. Herein, we characterize these CFU-Fs and investigate their potential role IH pathogenesis, before after propranolol therapy. The CFU-F phenotype (by flow cytometry), differentiation capacity ability to support angiogenesis cultures) gene expression RT-PCR) were evaluated. found actual circulating MSCs (cMSCs). In T0, cMSCs had...
<b><i>Introduction:</i></b> In 1991, we reported 18 persons with a clinical-pathologic entity and termed atypical myeloproliferative disorder because they did not meet the contemporary diagnostic criteria for neoplasm. We sought to gain further knowledge on this disease entity. <b><i>Methods:</i></b> This retrospective cohort study included consecutive subjects registered in database of Center Study Myelofibrosis Pavia, Italy, from 1998 2020...
Semantic impairment in patients with Alzheimer's disease (AD) is revealed by tasks of verbal naming, fluency, and semantic knowledge. Causes the deficit remain unclear spite many studies to investigate whether AD suffer from inability have voluntary access an almost intact store or its break down. Word‐stem completion (WSC) been utilized healthy subjects order study memory network exploiting possibility involuntary them. Available conflicting data refer presence prime patients. To explore...
About 15% of people with a myeloproliferative neoplasm (MPN) are identified as MPN, unclassifiable using the 2016 WHO classification.We tested whether persons platelet concentration ≥450 × 10E+9/L, bone marrow megakaryocyte morphology typical prefibrotic/early myelofibrosis (pre-MF), and no minor criteria pre-MF should be classified distinct MPN subtype, clonal dysplasia isolated thrombocytosis (CMD-IT).139 subjects meet these who we compared primary (PMF) including 402 521 overt...
We evaluated the association of VEGFA rs3025039 polymorphism with clinical co-variates and outcomes in 849 subjects primary myelofibrosis (PMF) 250 healthy controls. Minor T-allele frequency was higher JAK2V617F compared those without (18% vs. 13%; p = 0.014). In JAK2V617F, TT genotype associated at diagnosis lower platelet concentrations (p 0.033), plasma LDH concentration 0.005), blood CD34-positive cells 0.027), cholesterol 0.046), high-sensitivity C-reactive protein 0.018). These...
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by chronic inflammatory state that plays relevant role in the disease pathogenesis (as proven high levels of cytokines with prognostic significance and persistent oxidative stress) extensive neoangiogenesis bone marrow (BM) spleen. Myeloid-derived suppressor cells (MDSCs) are immature expand patients cancer, sepsis or inflammation, favoring tumor onset progression mainly through decrease immune surveillance promotion...
It has been demonstrated that mesenchymal stromal cells (MSCs) act by releasing bioactive molecules, among these are extracellular vesicles (EVs). The MSC-EVs considered a convenient alternative to cell therapy, showing several functional characteristics of their origin cells. EVs can be collected from conditioned in vitro cultured MSCs. Different processes have developed induce EV release, and approaches also influence MSC potentialities. This study aimed investigate the effect serum...
BCR::ABL-negative myeloproliferative neoplasms (MPNs) include the World Health Organization (WHO) defined classical MPNs, that is essential thrombocythaemia, polycythaemia vera (PV) and primary myelofibrosis (PMF). Recently, two new cognate phenotypes, is, clonal megakaryocyte dysplasia with normal blood values (CMD-NBV), isolated thrombocytosis (CMD-IT) have been proposed [1, 2]. These entities, along prefibrotic (pre-MF) overt-MF were unified by bone marrow (BM) myelofibrosis-type (MTMD)...