A5028827650- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Chronic Myeloid Leukemia Treatments
- Kruppel-like factors research
- Acute Myeloid Leukemia Research
- Platelet Disorders and Treatments
- Helicobacter pylori-related gastroenterology studies
- Multiple Myeloma Research and Treatments
- Iron Metabolism and Disorders
- Gastroesophageal reflux and treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Microscopic Colitis
- Potassium and Related Disorders
- Hemoglobinopathies and Related Disorders
- Eosinophilic Esophagitis
- Research on Leishmaniasis Studies
- Inflammation biomarkers and pathways
- Trace Elements in Health
- Chronic Lymphocytic Leukemia Research
- Autoimmune and Inflammatory Disorders Research
- Celiac Disease Research and Management
- Inflammatory Bowel Disease
- Blood disorders and treatments
- Cytokine Signaling Pathways and Interactions
- Autoimmune and Inflammatory Disorders
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2022
Foundation Center
2009-2022
Policlinico San Matteo Fondazione
2008-2021
University of Pavia
1999-2010
Summary The clinical and haematological phenotype of patients with myelofibrosis harbouring MPL W 515 L / K mutation has not been thoroughly investigated. Of 217 subjects, 18 (8·2%) had an mutation, four which (22%) co‐existed JAK2 V 617 F mutation. When compared wild‐type patients, irrespective status, those , were more frequently female, older (61 years vs. 57 years; P = 0·02), presented severe anaemia (haemoglobin, 101 g/l 121 g/l; 0·002) likely to require regular transfusional support (...
Purpose In the WHO diagnostic classification, prefibrotic myelofibrosis (pre-MF) is included in category of primary (PMF). However, strong evidence for this position lacking. Patients and Methods We investigated whether pre-MF may be aligned along a clinical biological continuum 683 consecutive patients who received diagnosis PMF. Results As compared with PMF-fibrotic type, (132 cases) showed female dominance, younger age, higher hemoglobin, platelet count, lower white blood cell smaller...
Increased mobilization of circulating endothelial progenitor cells may represent a new biological hallmark myeloproliferative neoplasms. We measured colony forming (ECFCs) in 106 patients with primary myelofibrosis, fibrotic stage, 49 prefibrotic 59 essential thrombocythemia or polycythemia vera, and 43 normal controls. Levels ECFC frequency for patient's characteristics were estimated by using logistic regression univariate multivariate setting. The sensitivity, specificity, likelihood...
Purpose The influence of JAK2 V617F mutation on blast transformation (BT) and overall survival (OS) in primary myelofibrosis (PMF) is controversial. In a large cohort patients we applied competing risks analysis for studying the JAK2V617F BT PMF. Patients Methods 462 PMF–fibrotic type (bone marrow [BM] fibrosis grade >0) computed incidence death framework Cox regression Fine Gray BT. Results At analysis, having either wild-type (wt) or homozygous genotype were factors (HR, 1.98 2.04,...
Single nucleotide polymorphisms (SNPs) can modify the individual pro-inflammatory background and may therefore have relevant implications in MPN setting, typified by aberrant cytokine production. In a cohort of 773 primary myelofibrosis (PMF), we determined contribution rs1024611 SNP CCL2—one most potent immunomodulatory chemokines—to clinical biological characteristics disease, demonstrating that male subjects carrying homozygous genotype G/G had an increased risk PMF that, among patients,...
Abstract Myelofibrosis (MF) belongs to the family of classic Philadelphia-negative myeloproliferative neoplasms (MPNs). It can be primary myelofibrosis (PMF) or secondary (SMF) evolving from polycythemia vera (PV) essential thrombocythemia (ET). Despite differences, PMF and SMF patients are currently managed in same way, prediction survival is based on clinical genetic features. In last few years, interest has grown concerning ability gene expression profiles (GEPs) provide valuable...
Abstract Splenic hematopoiesis is a major feature in the course of myelofibrosis (MF). In fact, spleen patients with MF contains malignant hematopoietic stem cells retaining complete differentiation program, suggesting both pivotal role maintaining disease and tight regulation by splenic microenvironment, particular mesenchymal stromal (MSCs). Little known about MSCs (Sp‐MSCs), normal pathological context. this work, we have vitro expanded characterized Sp‐MSCs from 25 13 healthy subjects...
Background Primary myelofibrosis (PMF) is an acquired clonal disease of the hematopoietic stem cell compartment, characterized by bone marrow fibrosis, anemia, splenomegaly and extramedullary hematopoiesis. About 60% patients with PMF harbor a somatic mutation JAK2 gene (JAK2-V617F) in their lineage. Recently, splicing isoform JAK2, lacking exon 14 (JAK2Δ14) was described affected myeloproliferative diseases. Materials Methods By using specific RT-qPCR method, we measured ratio between...
<b><i>Introduction:</i></b> In 1991, we reported 18 persons with a clinical-pathologic entity and termed atypical myeloproliferative disorder because they did not meet the contemporary diagnostic criteria for neoplasm. We sought to gain further knowledge on this disease entity. <b><i>Methods:</i></b> This retrospective cohort study included consecutive subjects registered in database of Center Study Myelofibrosis Pavia, Italy, from 1998 2020...