A5076948681- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Chronic Myeloid Leukemia Treatments
- Kruppel-like factors research
- Acute Myeloid Leukemia Research
- Platelet Disorders and Treatments
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Angiogenesis and VEGF in Cancer
- Multiple Myeloma Research and Treatments
- Immune cells in cancer
- Congenital Diaphragmatic Hernia Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cell Adhesion Molecules Research
- Mesenchymal stem cell research
- Neonatal Respiratory Health Research
- Vascular Malformations and Hemangiomas
- Lymphatic System and Diseases
- MicroRNA in disease regulation
- Vascular Malformations Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Erythropoietin and Anemia Treatment
- Respiratory Support and Mechanisms
- melanin and skin pigmentation
Policlinico San Matteo Fondazione
2012-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2025
Foundation Center
2009-2022
University of Pavia
2013
MRC Epidemiology Unit
2013
University of Illinois Urbana-Champaign
2005
Illinois College
2005
NHS Blood and Transplant
2004
Fondazione Salvatore Maugeri
2000-2003
Christie's
2002
The new form of bronchopulmonary dysplasia (BPD) is characterized by lung immaturity with disrupted alveolar and capillary development after extremely premature birth, but the mechanism impaired vascular formation still not completely understood.We tested hypothesis that reduced numbers circulating endothelial progenitor cells at birth are associated BPD.We studied ninety-eight preterm infants gestational age less than 32 weeks or a weight 1,500 g. Endothelial colony-forming (ECFCs) were...
Purpose In the WHO diagnostic classification, prefibrotic myelofibrosis (pre-MF) is included in category of primary (PMF). However, strong evidence for this position lacking. Patients and Methods We investigated whether pre-MF may be aligned along a clinical biological continuum 683 consecutive patients who received diagnosis PMF. Results As compared with PMF-fibrotic type, (132 cases) showed female dominance, younger age, higher hemoglobin, platelet count, lower white blood cell smaller...
To identify epitopes on Escherichia coli heat-shock protein (HSP) dnaJ or homologous human HSP involved in the induction/modulation of autoimmune inflammation patients with oligoarticular juvenile idiopathic arthritis (JIA).We used a proliferation assay and cytokine production to evaluate immune responses synovial fluid mononuclear cells (SFMCs) pan-HLA-DR binder peptides derived from either nonhomologous regions bacterial dnaJ. Cytofluorometric analysis was performed order phenotype sort...
Clonal endothelial progenitor cells (EPCs) have been implicated in the aberrant vascular growth that features infantile hemangioma (IH), most common benign tumor childhood may cause ulceration, bleeding, and/or permanent disfigurement. Endothelial colony-forming (ECFCs), truly EPCs endowed with clonal ability and capable of forming patent vessels vivo, remodel their Ca(2+) toolkit tumor-derived patients to acquire an adaptive advantage. Particularly, they upregulate proangiogenic...
Endothelial progenitor cells (EPCs) are present in circulation and contribute to vasculogenesis adults. We measured the number of circulating EPCs patients with myelofibrosis myeloid metaplasia (MMM), we examined relationship between severity MMM disease process.The was by assaying CD34+CD133+ vascular endothelial growth factor receptor 2 (VEGFR2) -positive cell phenotype 110 patients, 16 other Philadelphia-negative chronic myeloproliferative disorders (Ph-negative CMPDs), 14 healthy...
We studied plasma erythropoietin (EPO) levels and their relation with CD34+VEGFR-2+ (mature progenitor endothelial cells) CD34+ CD133+VEGFR-2+, or CD117+VEGFR-2+ (early/immature progenitors) cells in patients acute myocardial infarction (AMI). Fifty AMI undergoing percutaneous coronary intervention (PCI) within 6 h of symptom onset were enrolled. EPO, measured by ELISA, cell subsets, cytofluorimetric analysis, evaluated before PCI, 24 7 days afterwards. Forty-five healthy subjects (CTRLs)...
<title>Abstract</title> We report an in-depth retrospective analysis of updated series 30 subjects with clonal megakaryocyte dysplasia normal blood values (CMD-NBV). Sixteen were men, median age was 47.5 years (IQR, 39–53 years). A thrombosis-driven situational diagnosis (69% subjects), high incidence thrombotic events (6.5 x 100 subject-years), and indolent disease progression (one case only progressed towards active disease) the hallmarks CMD-NBV. Nineteen (63%) had a body mass index (BMI)...
Megakaryocytes release platelets into the bloodstream by elongating proplatelets. In this study, we showed that human megakaryocytes constitutively Transforming Growth Factor β1 and express its receptors. Importantly, downstream signaling, through SMAD2/3 phosphorylation, was shown to be active in extending proplatelets, indicating a type of autocrine stimulation on megakaryocyte development. Furthermore, inactivation receptor inhibitors SB431542 Stemolecule ALK5 inhibitor, determined...
Neoangiogenesis is an integral component of bone marrow myeloproliferation in patients with myelofibrosis myeloid metaplasia (MMM). As extramedullary haematopoiesis a constitutive feature MMM, we studied spleen neoangiogenesis by computerized image analysis MMM patients. Compared five normal subjects, CD34-staining capillary vascular density (CVD) was 2.1-3.03 times higher than the upper range six 15 (40%) CD8-staining sinusoidal (SVD) constantly or lesser and inversely correlated CVD (R =...
Although there has been extensive analysis on the capacity of MHC–peptide tetramers to bind antigen-specific TCR, have comparatively few studies regarding role CD4 and CD8 co-receptors in binding activation by these multimeric molecules. Here, we start from observation that different antibodies against human exert opposite effects tetramer TCR: staining was enhanced OKT8 antibody, while it blocked with SK1 antibody. We used anti-CD8 modulate function during Melan-A/MART1-specific CTL clones....