A5001557835- Hemophilia Treatment and Research
- Platelet Disorders and Treatments
- Ear and Head Tumors
- Reconstructive Facial Surgery Techniques
- Ear Surgery and Otitis Media
- Blood Coagulation and Thrombosis Mechanisms
- Mesenchymal stem cell research
- Laser Applications in Dentistry and Medicine
- Sarcoma Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Proteoglycans and glycosaminoglycans research
- Osteoarthritis Treatment and Mechanisms
- Vascular Malformations and Hemangiomas
- Myeloproliferative Neoplasms: Diagnosis and Treatment
University of Pavia
2024-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2024
Policlinico San Matteo Fondazione
2023-2024
We previously published that in patients with infantile hemangioma (IH) at the onset (T0) colony forming unit-fibroblasts (CFU-Fs) are present vitro cultures from PB. Herein, we characterize these CFU-Fs and investigate their potential role IH pathogenesis, before after propranolol therapy. The CFU-F phenotype (by flow cytometry), differentiation capacity ability to support angiogenesis cultures) gene expression RT-PCR) were evaluated. found actual circulating MSCs (cMSCs). In T0, cMSCs had...
Ossiculoplasty is a surgical operation performed to restore auditory transmission through the reconstruction of ossicular chain using prosthetics. Tissue bioengineering has assumed pivotal role in implementing alternatives conventional middle ear replacement prostheses, overcome extrusion while preserving acoustic properties. This vitro study aims explore, for first time current literature, feasibility biohybrid prosthesis, composed titanium surrounded by bone extracellular matrix as...
Introduction: Osteoarthritis is a degenerative condition of the cartilage, often common among population and occurs frequently with aging. Many factors are decisive for development its pathogenesis such as age, obesity, trauma, mechanical load, modification synovial biology. The main features osteoarthritis chondrocytes cartilage matrix loss, which lead to pain, loss function whole joint, disability, representing relevant health problem. Recently, new therapeutic approach based on cell...
Intra-articular blood, iron and hemosiderin, hydroxyl radical cytokines, neo-angiogenesis cause synovial inflammation, which leads to cartilage joint damage. Platelet-rich plasma (PRP) inhibits most of the mediators that produce maintain synovitis. We compile here our work showing clinical effectiveness intra-articular PRP injections their potential role in stopping articular damage due bleeding its possible repair. A total 116 joints, including knees (63%), elbows (19.8%), ankles (17.2%),...
Tissue bioengineering has been assuming a pivotal role in implementing alternatives to conven-tional ossicular middle ear replacement prostheses overcome extrusion while preserving acoustic properties. This vitro study aims explore for the first time current literature feasibility of biohybrid prosthesis composed titanium surrounded by bone ex-tracellular matrix as bio-coating. We have hereby studied adhesion and proliferation human adipose-derived mesenchymal stem cells (hASC) on scaffolds...