Isabelle Pin
A5023359341- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Allergic Rhinitis and Sensitization
- Air Quality and Health Impacts
- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Pediatric health and respiratory diseases
- Health, Environment, Cognitive Aging
- Noise Effects and Management
- Delphi Technique in Research
- Inhalation and Respiratory Drug Delivery
- Epigenetics and DNA Methylation
- Respiratory viral infections research
- Occupational exposure and asthma
- Effects and risks of endocrine disrupting chemicals
- IL-33, ST2, and ILC Pathways
- Climate Change and Health Impacts
- Neuroscience of respiration and sleep
- Food Allergy and Anaphylaxis Research
- Indoor Air Quality and Microbial Exposure
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Obstructive Sleep Apnea Research
- Tracheal and airway disorders
Centre Hospitalier Universitaire de Grenoble
2016-2025
Hôpital Couple Enfant
2010-2025
Université Grenoble Alpes
2015-2024
Institut pour l'avancée des biosciences
2015-2024
Inserm
2015-2024
Institut de Biosciences et Biotechnologies
2017-2024
Centre National de la Recherche Scientifique
2016-2024
Université Paris Cité
2000-2021
Assistance Publique – Hôpitaux de Paris
2021
Hôpital Cochin
1997-2021
BACKGROUND: Airway inflammation is considered to be important in asthma but relatively inaccessible study. Less invasive methods of obtaining sputum from patients unable produce it spontaneously should provide a useful investigational tool asthma. METHODS: A method induce with inhaled hypertonic saline was modified for use 17 asthmatic and normal subjects who could not spontaneously. The success rate safety the method, reproducibility cell counts, differences counts between groups were...
Data concerning the effects of prenatal exposures to phthalates and phenols on fetal growth are limited in humans. Previous findings suggest possible some male birth weight.Our aim was assess relationships between among newborns.We conducted a case-control study malformations genitalia nested two French mother-child cohorts with recruitment 2002 2006. We measured, maternal urinary samples collected 6 30 gestational weeks, concentrations (micrograms per liter) 9 phenol (n = 191 pregnant...
A genomewide association study has shown an between variants at chromosome 17q21 and increased risk of asthma. To elucidate the relationship this locus disease, we examined a large, family-based data set that included extensive phenotypic environmental from Epidemiological Study on Genetics Environment Asthma.We tested 36 single-nucleotide polymorphisms (SNPs) in region 1511 subjects 372 families for with We also genetic heterogeneity according to age onset asthma exposure tobacco smoke...
There is a need to improve asthma characterisation by integrating multiple aspects of the disease. The aim present study was identify distinct phenotypes applying latent class analysis (LCA), model-based clustering method, two large epidemiological studies. Adults with who participated in follow-up Epidemiological Study on Genetics and Environment Asthma (EGEA2) (n = 641) European Community Respiratory Health Survey (ECRHSII) 1,895) were included. 19 variables covering personal...
<b><i>Background:</i></b> This study is aimed at providing a real-world evaluation of the economic cost persistent asthma among European adults according to degree disease control [as defined by 2006 Global Initiative for Asthma (GINA) guidelines]. <b><i>Methods:</i></b> A prevalence-based cost-of-illness was carried out on 462 patients aged 30–54 years with (according 2002 GINA definition), who were identified in general population samples...
Rationale: Elexacaftor-tezacaftor-ivacaftor is a CFTR (cystic fibrosis [CF] transmembrane conductance regulator) modulator combination, developed for patients with CF at least one Phe508del mutation. Objectives: To evaluate the effects of elexacaftor-tezacaftor- ivacaftor in and advanced respiratory disease. Methods: A prospective observational study, including all aged ⩾12 years percent-predicted FEV1 (ppFEV1) <40 who initiated elexacaftor-tezacaftor-ivacaftor from December 2019 to August...
The role of smoking as potential risk factor, selection factor ("healthy smoker" effect) and modifying (severity) asthma was studied in the Epidemiological study on Genetics Environment Asthma, bronchial hyperresponsiveness atopy (EGEA). analysis involved 200 adult asthmatic cases recruited chest clinics, 265 nonasthmatic controls 586 relatives asthmatics (147 with asthma). Asthma childhood not associated a reduced take-up (odds ratio (OR)=1.06 males 0.98 females), but smoker quit more often...
A genome-wide search was conducted in 107 nuclear families with at least two siblings asthma, as part of the French EGEA study. two-stage analysis strategy applied to divided into independent subsets 46 and 61 families, where all regions detected first set were tested for replication second set. In addition, reported by published genome scans different populations examined total sample. 254 markers typed 70% them Linkage investigated model-free methods asthma four asthma-related phenotypes:...
Asthma severity in relation to body mass index (BMI) has rarely been studied. The between BMI and asthma was studied by sex 366 adults with from the Epidemiological Study on Genetics Environment of Asthma, a case-control family study asthma. Factors related such as smoking, FEV(1), bronchial hyperresponsiveness, dyspnea were taken into account. influence early menarche assess potential role hormonal factors. Clinical last 12 months assessed score (0-7) based frequency attacks, persisting...
Allergen inhalation causes airway inflammation and an increase in histamine responsiveness. We have used cell counts sputum induced by hypertonic saline aerosol to assess before 32 h after asthmatic responses allergen. Twelve subjects (mean age, 27.4 yr; range, 20–38 yr) had test with D. farinae, ragweed pollen, or cat extract. All of them developed early response a fall FEV1 24.8% (SD, 6.3%); nine 12 definite late (fall ⩾ 15%), 10 responsiveness at (PC20 reduced greater than twofold)....
Omalizumab has been shown to reduce exacerbation rates in moderate severe allergic asthma. Our aim was evaluate omalizumab efficacy and safety a real-life setting asthmatic children. 104 children (aged 6–18 years), followed up paediatric pulmonary tertiary care centres, were included at the beginning of treatment. Asthma control levels, exacerbations, inhaled corticosteroid dose, lung function adverse events evaluated over 1 year. Children characterised by sensitisation three or more...
Abstract By moving essential body fluids and molecules, motile cilia flagella govern respiratory mucociliary clearance, laterality determination the transport of gametes cerebrospinal fluid. Primary ciliary dyskinesia (PCD) is an autosomal recessive disorder frequently caused by non-assembly dynein arm motors into axonemes. Before their import flagella, multi-subunit axonemal arms are thought to be stabilized pre-assembled in cytoplasm through a DNAAF2–DNAAF4–HSP90 complex akin HSP90...
Rationale: Menopause is associated with changes in sex hormones, which affect immunity, inflammation, and osteoporosis may impair lung function. Lung function decline has not previously been investigated relation to menopause.Objectives: To study whether decline, assessed by FVC FEV1, accelerated women who undergo menopause.Methods: The population-based longitudinal European Community Respiratory Health Survey provided serum samples, spirometry, questionnaire data about respiratory...
Rationale: Lumacaftor-ivacaftor is a CFTR (cystic fibrosis transmembrane conductance regulator) modulator combination recently approved for patients with cystic (CF) homozygous the Phe508del mutation.Objectives: To evaluate safety and effectiveness of lumacaftor-ivacaftor in adolescents (≥12 yr) adults (≥18 real-life postapproval setting.Methods: The study was conducted 47 CF reference centers France. All who initiated from January 1 to December 31, 2016, were eligible. Patients evaluated...
The temporal stability of adult asthma phenotypes identified using clustering methods has never been addressed. Longitudinal cluster-based may provide novel insights in the study natural history asthma.To compare phenotype structures a decade apart adults and to address individuals' phenotypic transition across these phenotypes.The latent analysis was applied on longitudinal data (twice, 10 yr apart) from 3,320 with who took part European Community Respiratory Health Survey, Swiss Cohort...