A5024663629- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Cystic Fibrosis Research Advances
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory and Cough-Related Research
- Health and Wellbeing Research
- Tuberculosis Research and Epidemiology
- Pulmonary Hypertension Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Tracheal and airway disorders
- Inhalation and Respiratory Drug Delivery
- Mesenchymal stem cell research
- Delphi Technique in Research
- Venous Thromboembolism Diagnosis and Management
- Atomic and Subatomic Physics Research
- Respiratory viral infections research
- Infectious Diseases and Tuberculosis
- Pneumonia and Respiratory Infections
- Air Quality and Health Impacts
- RNA modifications and cancer
- Pleural and Pulmonary Diseases
University of Ulsan
2016-2025
Asan Medical Center
2016-2025
Ulsan College
2016-2025
Seoul National University of Science and Technology
2024-2025
Kyungpook National University
2024
Seoul St. Mary's Hospital
2023
Catholic University of Korea
2010-2023
University of British Columbia
2022
GlaxoSmithKline (United States)
2020
Ulsan University Hospital
2005-2019
Background The Continuing to Confront COPD International Patient Survey estimated the prevalence and burden of across 12 countries. Using data from this survey we evaluated economic impact COPD. Methods This cross-sectional, population-based questioned 4,343 subjects aged 40 years older, fulfilling a case definition based on self-reported physician diagnosis or symptomatology. Direct cost measures were exacerbations (treated those requiring emergency department visits and/or...
The therapeutic potential of stem cells in chronic obstructive pulmonary disease is not well known although cell therapy effective models other diseases. We tested the capacities bone marrow (BMCs), mesenchymal (MSCs), and conditioned media MSCs (MSC-CM) to repair cigarette smoke-induced emphysema. Inbred female Lewis rats were exposed smoke for 6 mo then received BMCs, MSCs, or MSC-CM from male rats. For 2 after injection, BMC treatment gradually alleviated emphysema restored increased mean...
Background: Little information is available regarding medical utilization and cost in patients with overlap syndrome of chronic obstructive pulmonary disease (COPD) asthma. The purpose this study to analyze compare them COPD without Methods: Using the 2009 Korean National Health Insurance (NHI) database, were identified. Medical costs also analyzed. Results: Of a total 185,147 identified COPD, 101,004 classified asthma 84,143 In 2009, percentages emergency room visits, admissions, intensive...
We evaluated the predictive value of COPD assessment test (CAT™) for exacerbation in following six months or time to first among patients with previous exacerbations.COPD outpatients a history from 19 hospitals completed CAT questionnaire and spirometry over months. Exacerbation events were prospectively collected using structured questionnaire.The baseline score categorised into four groups (0–9, 10–19, 20–29, 30–40) showed strong prediction modest any moderate-severe (AUC 0.83, 0.64, 0.63...
Abstract Background Gastroesophageal reflux disease (GERD) is one of the most common causes chronic cough and a potential risk factor for exacerbation obstructive pulmonary (COPD). The aim this study was to investigate prevalence factors GERD in patients with COPD association between exacerbation. Methods Data were collected from National Health Insurance Database Korea. subjects 40 years old older, who had as primary or secondary diagnosis codes utilized health care resource receive...
Recent work has suggested a microbial dysbiosis association between the lung and gut in respiratory diseases. Here, we demonstrated that microbiome modulation attenuated emphysema development. To modulate microbiome, fecal microbiota transplantation (FMT) diet modification were adopted mice exposed to smoking poly I:C for model. We analyzed severity of by mean linear intercept (MLI) apoptosis fluorescent TUNEL assay. Microbiome analysis was also performed feces extracellular vesicles (EVs)....
To develop a system for texture-based quantification of emphysema on high-resolution computed tomography (HRCT) and to compare it with density-based in correlation pulmonary function test (PFT).Two hundred sixty-one circular regions interest (ROI) 16-pixel diameter [66 ROIs representing typical area normal lung; 69 bronchiolitis obliterans (BO); 64, mild (ME); 62, severe (SE)] were used train the automated classification based Support Vector Machine classifier variable texture shape...
Purpose: To assess the feasibility of xenon ventilation computed tomography (CT) for evaluating abnormality in asthmatics. Materials and Methods: Twenty-two, stable asthmatics (M:F = 10:12; mean age, 57.6) were included. Single-phase, whole-thorax, dual-energy CT was performed using dual-source (Somatom Definition, Siemens) after subjects had inhaled 30% 90 seconds. Parameters include 512 × matrix; 14 1.2 mm collimation; 40/140 eff. mAs at 140/80 kV; 0.45 pitch; 0.33 seconds rotation time....
Multicentre study.To define the clinical characteristics of patients with tuberculosis (TB) destroyed lung due to past TB.We reviewed TB-destroyed between May 2005 and June 2011.A total 595 from 21 hospitals were enrolled. The mean age was 65.63 ± 0.47 (mean standard error); 60.5% male. number lobes involved 2.59 0.05. Pleural thickening observed in 54.1% patients. Mean forced vital capacity (FVC), expiratory volume 1 s (FEV(1)), FEV(1)/FVC, bronchodilator response exacerbations per year...
Background and Objectives. Chronic obstructive pulmonary disease (COPD) is a complex characterized by airflow limitation. Although airway inflammation oxidative stress are known to be important in the pathogenesis of COPD, mechanism underlying obstruction not fully understood. Gene expression profiling lung tissue was performed define molecular pathways that dysregulated COPD. Methods. RNA isolated from tissues obtained 98 subjects with COPD 91 control normal spirometry. The samples were...
Cigarette smoking causes apoptotic death, senescence, and impairment of repair functions in lung fibroblasts, which maintain the integrity alveolar structure by producing extracellular matrix (ECM) proteins. Therefore, recovery fibroblasts from cigarette smoke-induced damage may be crucial regeneration emphysematous resulting degradation ECM proteins subsequent loss cells. Recently, we reported that bone marrow-derived mesenchymal stem cell-conditioned media (MSC-CM) led to angiogenesis...
Cell therapy using stem cells has produced therapeutic benefits in animal models of COPD. Secretory mediators are proposed as one mechanism for cell effects because very few engraft after injection into recipient animals. Recently, nanovesicles that overcome the disadvantages natural exosomes have been generated artificially from cells. We artificial adipose-derived (ASCs) sequential penetration through polycarbonate membranes. ASC-derived displayed a 100 nm-sized spherical shape similar to...
Cigarette smoke (CS) and viruses promote the inflammation remodeling associated with chronic obstructive pulmonary disease (COPD). The MAVS/RIG-I-like helicase (MAVS/RLH) pathway inflammasome-dependent innate immune pathways are important mediators of these responses. At baseline, MAVS/RLH is suppressed, this inhibition must be reversed to engender tissue effects; however, mechanisms that mediate activation repression have not been defined. In addition, regulation contribution signaling in...
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease, and bacterial infection plays role in its pathogenesis. Bacteria secrete nanometer-sized extracellular vesicles (EVs), which may induce more immune dysfunction inflammation than the bacteria themselves. We hypothesized that microbiome of lung EVs might have distinct characteristics depending on presence COPD smoking status. analyzed compared microbiomes 13 nonsmokers with normal spirometry, smokers spirometry...
Abstract Background Oral CXC chemokine receptor 2 (CXCR2) antagonists have been shown to inhibit neutrophil migration and activation in the lung preclinical human models of neutrophilic airway inflammation. A previous study with danirixin, a reversible CXCR2 antagonist, demonstrated trend for improved respiratory symptoms health status patients COPD. Methods This 26-week, randomised, double-blind, placebo-controlled phase IIb enrolled symptomatic mild-to-moderate COPD at risk exacerbations....