Wim Timens
A5034491326- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immunotherapy and Immune Responses
- Pediatric health and respiratory diseases
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- IL-33, ST2, and ILC Pathways
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Respiratory Support and Mechanisms
- Lung Cancer Diagnosis and Treatment
- Respiratory and Cough-Related Research
- Lung Cancer Research Studies
- Pulmonary Hypertension Research and Treatments
- Inhalation and Respiratory Drug Delivery
- Immune Cell Function and Interaction
- Medical Imaging and Pathology Studies
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- MicroRNA in disease regulation
- Pleural and Pulmonary Diseases
University Medical Center Groningen
2016-2025
University of Groningen
2016-2025
Institute for Asthma and Allergy
2013-2024
Dialyse Centrum Groningen
1996-2024
International Association for the Study of Lung Cancer
2024
Rijnstate Hospital
2024
Metropolitan University
2019
Hospital for Sick Children
2018
University of British Columbia
2012-2018
St. Paul's Hospital
2018
Severe acute respiratory syndrome (SARS) is an infectious disease that spreads mainly via the route. A distinct coronavirus (SARS-CoV) has been identified as aetiological agent of SARS. Recently, a metallopeptidase named angiotensin-converting enzyme 2 (ACE2) functional receptor for SARS-CoV. Although ACE2 mRNA known to be present in virtually all organs, its protein expression largely unknown. Since identifying possible route infection major implications understanding pathogenesis and...
The use of multidetector computed tomography (CT) in lung-cancer screening trials involving subjects with an increased risk lung cancer has highlighted the problem for clinician deciding on best course action when noncalcified pulmonary nodules are detected by CT.A total 7557 participants underwent CT years 1, 2, and 4 a randomized trial screening. We used software to evaluate nodule according its volume or volume-doubling time. Growth was defined as increase at least 25% between two scans....
FGFR1 amplification provides a therapeutic target for squamous cell lung cancer, which is resistant to other targeted cancer drugs.
While genomically targeted therapies have improved outcomes for patients with lung adenocarcinoma, little is known about the genomic alterations which drive squamous cell cancer. Sanger sequencing of tyrosine kinome identified mutations in DDR2 kinase gene 3.8% cancers and lines. Squamous cancer lines harboring were selectively killed by knock-down RNAi or treatment multi-targeted inhibitor dasatinib. Tumors established from a mutant line sensitive to dasatinib xenograft models. Expression...
The pattern of mutations in human lung cancer differs by tumor subtype and is a useful addition to histology for selecting targeted therapy improving patient survival.
Single-cell technologies have transformed our understanding of human tissues. Yet, studies typically capture only a limited number donors and disagree on cell type definitions. Integrating many single-cell datasets can address these limitations individual the variability present in population. Here we integrated Human Lung Cell Atlas (HLCA), combining 49 respiratory system into single atlas spanning over 2.4 million cells from 486 individuals. The HLCA presents consensus re-annotation with...
Genome-wide association studies (GWAS) have identified loci reproducibly associated with pulmonary diseases; however, the molecular mechanism underlying these associations are largely unknown. The objectives of this study were to discover genetic variants affecting gene expression in human lung tissue, refine susceptibility for asthma GWAS studies, and use genetics network analyses find key drivers asthma. We performed a genome-wide search quantitative trait (eQTL) 1,111 samples. eQTL...
BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with high mortality, uncertain cause, and few treatment options. Studies have identified significant genetic risk associated the development of IPF; however, mechanisms by which factors promote IPF remain unclear. We aimed to identify variants susceptibility provide mechanistic insight using gene protein expression analyses.MethodsWe used two-stage approach: genome-wide association study in patients European...
Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by scarring of the that believed to result from an atypical response injury epithelium. Genome-wide association studies have reported signals implicating multiple pathways including host defense, telomere maintenance, signaling, and cell-cell adhesion.Objectives: To improve our understanding factors increase IPF susceptibility identifying previously unreported genetic associations.Methods: We conducted...
Abstract Objectives In non‐small cell lung cancer (NSCLC), the immune system and possibly its composition affect survival. this in silico study, infiltrate NSCLC patients was evaluated. Methods Gene expression data of tumors from early were obtained Expression Omnibus (GEO). With CIBERSORT, 22 fractions estimated. Results The 1430 pretreatment contained mostly plasma cells, macrophages CD8 T cells. Higher resting mast CD4 T‐helper cells associated with longer overall survival (OS) (HR =...
Abstract To identify candidate causal genes of asthma, we performed a genome-wide association study (GWAS) in UK Biobank on broad asthma definition (n = 56,167 cases and 352,255 controls). We then carried out functional mapping through transcriptome-wide studies (TWAS) Mendelian randomization lung 1,038) blood 31,684) tissues. The GWAS reveals 72 asthma-associated loci from 116 independent significant variants (P < 5.0E-8). most TWAS gene 17q12-q21 is GSDMB 1.42E-54). Other include TSLP...
Immune checkpoint inhibitors (ICIs), by reinvigorating CD8+ T cell mediated immunity, have revolutionized cancer therapy. Yet, the systemic distribution, a potential biomarker of ICI response, remains poorly characterized. We assessed safety, imaging dose and timing, pharmacokinetics immunogenicity zirconium-89-labeled, CD8-specific, one-armed antibody positron emission tomography tracer 89ZED88082A in patients with solid tumors before ~30 days after starting therapy (NCT04029181). No...