A5036276427- Genetic and phenotypic traits in livestock
- Immunotherapy and Immune Responses
- Reproductive Physiology in Livestock
- Cancer Immunotherapy and Biomarkers
- Livestock Management and Performance Improvement
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- T-cell and B-cell Immunology
- Agricultural Economics and Practices
- Effects of Environmental Stressors on Livestock
- Monoclonal and Polyclonal Antibodies Research
- Neuropeptides and Animal Physiology
- Peptidase Inhibition and Analysis
- Birth, Development, and Health
- Animal health and immunology
- Reproductive Biology and Fertility
- Immune cells in cancer
- Immune Response and Inflammation
- Mycobacterium research and diagnosis
- Infant Nutrition and Health
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Genomics and Diagnostics
- Child Nutrition and Feeding Issues
- Ruminant Nutrition and Digestive Physiology
Computer Algorithms for Medicine
2023
Sawai ManSingh Medical College and Hospital
2021-2023
Central Institute of Technology Kokrajhar
2023
Lady Hardinge Medical College
1988-2022
Kalawati Saran Children's Hospital
2022
Roche (United States)
2021
Roche (Ireland)
2021
Gajara Raja Medical College
2020
National Dairy Research Institute
2017
Maharana Pratap University of Agriculture and Technology
2017
Abstract Pancreatic ductal adenocarcinoma (PDAC) is lethal in 88% of patients 1 , yet harbours mutation-derived T cell neoantigens that are suitable for vaccines 2,3 . Here a phase I trial adjuvant autogene cevumeran, an individualized neoantigen vaccine based on uridine mRNA–lipoplex nanoparticles, we synthesized mRNA real time from surgically resected PDAC tumours. After surgery, sequentially administered atezolizumab (an anti-PD-L1 immunotherapy), cevumeran (a maximum 20 per patient) and...
Foxp3+ CD4+ T helper cells called regulatory (T reg) play a key role in controlling reactivity to self-antigens and onset of autoimmunity. reg either arise thymus are natural (nT or generated the periphery through induction Foxp3 inducible (iT cells. The relative contributions iT nT peripheral tolerance remain unclear as result an inability separate these two subsets Using combination novel TCR transgenic mice with defined self-antigen specificity conventional mouse models, we demonstrate...
Thymically derived Foxp3(+) regulatory T cells (tTregs) constitute a unique cell lineage that is essential for maintaining immune tolerance to self and homeostasis. However, Foxp3 can also be turned on in conventional as consequence of antigen exposure the periphery, under both non-inflammatory inflammatory conditions. These so-called peripheral Tregs (pTregs) participate control immunity at sites inflammation, especially mucosal surfaces. Although numerous studies have assessed vitro...
Regulatory T cells (Tregs) play a central role in counteracting inflammation and autoimmunity. A more complete understanding of cellular heterogeneity the potential for lineage plasticity human Treg subsets may identify markers disease pathogenesis facilitate development optimized therapeutics. To better elucidate subsets, we conducted direct transcriptional profiling CD4(+)FOXP3(+)Helios(+) thymic-derived Tregs CD4(+)FOXP3(+)Helios(-) cells, followed by comparison with...
Immune checkpoint inhibitors (ICIs), by reinvigorating CD8+ T cell mediated immunity, have revolutionized cancer therapy. Yet, the systemic distribution, a potential biomarker of ICI response, remains poorly characterized. We assessed safety, imaging dose and timing, pharmacokinetics immunogenicity zirconium-89-labeled, CD8-specific, one-armed antibody positron emission tomography tracer 89ZED88082A in patients with solid tumors before ~30 days after starting therapy (NCT04029181). No...
There is strong evidence that immunotherapy-mediated tumor rejection can be driven by tumor-specific CD8+ T cells reinvigorated to recognize neoantigens derived from somatic mutations. Thus, the frequencies or characteristics of tumor-reactive, mutation-specific could used as biomarkers an anti-tumor response. However, such neoantigen-specific are difficult reliably identify due their low frequency in peripheral blood and wide range potential epitope specificities.Peripheral mononuclear...
Abstract Tumors with microsatellite instability (MSI) are caused by a defective DNA mismatch repair system that leads to the accumulation of mutations within regions. Indels in microsatellites coding genes can result synthesis frameshift peptides (FSP). FSPs tumor-specific neoantigens shared across patients MSI. In this study, we developed neoantigen-based vaccine for treatment MSI tumors. Genetic sequences from 320 tumor biopsies and matched healthy tissues The Cancer Genome Atlas database...
Background A growing body of evidence suggests that T-cell responses against neoantigens are critical regulators response to immune checkpoint blockade. We previously showed circulating neoantigen-specific CD8 T cells in patients with lung cancer responding anti-Programmed death-ligand 1 (PD-L1) (atezolizumab) exhibit a unique phenotype high expression CD57, CD244, and KLRG1. Here, we extended our analysis on metastatic urothelial (mUC) further profiled total identify blood-based predictive...
2516 Background: Pancreas ductal adenocarcinoma (PDAC) is a lethal cancer that claims ̃90% of patients in <24 months diagnosis. PDAC also refractory to immunotherapy as most tumors exhibit an immune excluded/desert phenotype. However, although characterized by low mutation rates, PDACs harbor mutations can generate immunogenic neoantigens. Here, we report the results phase-I trial autogene cevumeran, systemic RNA-lipoplex individualized neoantigen-specific (iNeST) vaccine, stimulate...
Abstract Previous studies have shown the mitogen-activated protein kinases (MAPKs) to be activated in macrophages upon infection with Mycobacterium, and that expression of TNF-α inducible NO synthase by infected was dependent on MAPK activation. Additional analysis demonstrated a diminished activation p38 extracellular signal-regulated kinase (ERK)1/2 pathogenic strains Mycobacterium avium compared infections fast-growing, nonpathogenic smegmatis phlei. However, upstream signals required for...
Abstract Genetic and epigenetic alterations can distinguish cancer cells from their normal counterparts, allowing tumors to be recognized as foreign by the immune system. The system's ability detect destroy these abnormal is foundation of immunotherapy. In order for this occur must traffic persist in tumors. Programmed death-ligand 1 (PD-L1; also called B7-H1 or CD274), which expressed on many tumor-infiltrating cells, plays an important part blocking immune-mediated tumor cell destruction...
Abstract Previous studies have shown that the ability of Mycobacterium tuberculosis to block a Ca2+ flux is an important step in its capacity halt phagosome maturation. This affect on release results from M. inhibition sphingosine kinase (SPK) activity. However, these did not address potential role SPK and other aspects macrophage activation including production proinflammatory mediators. We previously showed nonpathogenic smegmatis lesser extent pathogenic avium, activate Ca2+-dependent...
Summary L eishmania major is an aetiological agent of cutaneous leishmaniasis. The parasite primarily infects immune sentinel cells, specifically macrophages and dendritic in the mammalian host. Infection receptor mediated known to involve binding cell surface protein complement 3 ( CR 3, M ac‐1, CD 11b/ 18). Engagement by various ligands inhibits production interleukin‐12 IL ‐12), cytokine that drives antileishmanial T helper 1‐type responses. Likewise, . infection ‐12 activation host...
Immune cellular effects of vasoactive intestinal peptide (VIP) are transduced by VIP G protein-coupled receptors type 1 (VPAC1) and 2 (VPAC2). We now show that with TGFbeta stimulates the transformation CD4 T cells to a distinctive Th17 cell generates IL-17 but not IL-6 or IL-21. induction was higher in VPAC2 knockout mice than wild-type mice, suggesting VPAC1 is principal transducer. Compared elicited IL-6, those evoked were similar secretion IL-22, lacked IL-21 secretion. Suppression...
Abstract Background: Neoantigens arising from somatic mutations are attractive targets for cancer immunotherapy as they may be recognized foreign by the immune system. RO7198457 is a systemically administered RNA-Lipoplex iNeST designed to stimulate T cell responses against neoantigens. A first-in-human Phase Ia study of was conducted in patients with locally advanced or metastatic solid tumors. Methods: manufactured on per-patient basis and contains up 20 patient- specific Nine doses were...