A5068279581- Immune Response and Inflammation
- interferon and immune responses
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Antimicrobial Peptides and Activities
- Inflammasome and immune disorders
- Monoclonal and Polyclonal Antibodies Research
- Advanced Fluorescence Microscopy Techniques
- Immune Cell Function and Interaction
- Quantum Dots Synthesis And Properties
- Immunotherapy and Immune Responses
- Cancer Risks and Factors
- Glioma Diagnosis and Treatment
- Advanced Electron Microscopy Techniques and Applications
- Global Cancer Incidence and Screening
- Pediatric health and respiratory diseases
- Nanocluster Synthesis and Applications
- Hepatitis Viruses Studies and Epidemiology
- CAR-T cell therapy research
- RNA modifications and cancer
- Force Microscopy Techniques and Applications
- Multiple and Secondary Primary Cancers
- Meningioma and schwannoma management
- Biopolymer Synthesis and Applications
- Escherichia coli research studies
University of California, Berkeley
2014-2018
St. Joseph's Hospital and Medical Center
2009
National Cancer Institute
2009
United States Department of Health and Human Services
2009
National Institutes of Health
2009
Science Applications International Corporation (United States)
2009
Division of Cancer Epidemiology and Genetics
2009
Western Pennsylvania Hospital
2009
Brigham and Women's Hospital
2009
Barrow Neurological Institute
2009
Abstract Background: Cancer epidemiology articles often point out that cancer rates tend to be higher among males than females yet rarely is this theme the subject of investigation. Methods: We used Surveillance, Epidemiology and End Results program data compute age-adjusted (2000 U.S. standard population) sex-specific incidence male-to-female rate ratios (IRR) for specific sites histologies period 1975 2004. Results: The 10 cancers with largest IRR were Kaposi sarcoma (28.73), lip (7.16),...
Although the etiology of primary brain tumors is largely unknown, prior studies suggest that DNA repair polymorphisms may influence risk glioma. Altered also likely to affect meningioma and acoustic neuroma, but these have not been well studied. We estimated glioma (n = 362), 134), neuroma 69) in non-Hispanic whites with respect 36 single nucleotide from 26 genes involved a hospital-based, case–control study conducted by National Cancer Institute. observed significantly increased T variant...
Semiconductor quantum dots (QDs) have proven to be superior probes for single-molecule imaging compared organic or genetically encoded fluorophores, but they are limited by difficulties in protein targeting, their larger size, and on–off blinking. Here, we report compact aqueous CdSe/CdS QDs with significantly improved bioconjugation efficiency optical properties. We synthesized covalent labeling ligands (i.e., SNAP tags) that optimized nanoparticle use, functionalized these label...
Toll-like receptors 7 (TLR7) and 8 (TLR8) each sense single-stranded RNA (ssRNA), but their activation results in different immune profiles. Attempts to selectively target either TLR7 or TLR8 have been hindered by high degree of homology. However, recent studies revealed that bind ligands resulting from the processing ssRNA endolysosomal RNases. We demonstrate introducing precise 2′ sugar-modified bases into oligoribonucleotides (ORNs) containing known binding motifs, we could prevent...
Despite the need to monitor impact of Cancer Immunotherapy (CI)/Immuno-Oncology (IO) therapeutics on neoantigen-specific T-cell responses, very few clinical programs incorporate this aspect immune monitoring due challenges in high-throughput (HTP) generation Major Histocompatibility Complex Class I (MHCI) tetramers across a wide range HLA alleles. This limitation was recently addressed through development MHCI complexes with peptides containing nonnatural UV cleavable amino acid (conditional...
Abstract CD4 T cells have long been known to be critical for priming CD8 cells, a process referred as cell help. Recent data suggested that help may delivered at the surface of conventional type 1 dendritic (cDC1s), which can efficiently present antigens (Ag) on both MHC class I and II molecules. However, actual mechanisms underlying remain poorly characterized. We sought understand how anti-tumor responses are generated in context mRNA vaccines, shown elicit protective and/or cells. For...
Abstract Messenger RNA (mRNA) has emerged as a new class of therapeutic agent delivered by carrier lipoplex (LPX) to elicit an immune-response for treating various diseases, including cancers. However, the PK and tissue distribution components is not well characterized given its novelty structural complexity. As such, this study aimed characterize metabolic fate LPX-mRNA using radiolabeled DOTMA, component therapeutic, aid development anti-cancer agent. To track LPX-mRNA, DOTMA was first...
Abstract Excessive systemic inflammation is characteristic to various acute conditions including sepsis, viral infections and immunotherapy-induced adverse events such as cytokine release syndrome (CRS). Recently, several clinical trials evaluating variants of lipid-formulated RNA vaccines for either cancer or COVID-19 have reported inflammatory responses that limit vaccine dosing in humans. Preclinical studies inbred laboratory mice failed predict these events, suggesting the existence...
<h3>Background</h3> Toll-like receptors (TLRs) are an integral part of innate immune cell activation and play essential role in mounting effective antigen-specific adaptive responses. TLR7 TLR8 highly homologous TLR family members that recognize ssRNA derived from viruses induce distinct cytokine profiles due to differential expression cells. Recent studies demonstrate degraded products generated by endosomal RNases. We hypothesized site-specific modifications foundational sequences...