A5072634086- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Nutritional Studies and Diet
- Folate and B Vitamins Research
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Eosinophilic Esophagitis
- RNA modifications and cancer
- Carcinogens and Genotoxicity Assessment
- Colorectal Cancer Screening and Detection
- Gastroesophageal reflux and treatments
- Air Quality and Health Impacts
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Antioxidant Activity and Oxidative Stress
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Obesity, Physical Activity, Diet
- Lung Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Global Cancer Incidence and Screening
- Nutrition and Health in Aging
- Cancer Genomics and Diagnostics
National Institutes of Health
2016-2025
National Cancer Institute
2016-2025
Division of Cancer Epidemiology and Genetics
2015-2024
National Cancer Institute
1993-2023
New York University Press
2022
Cambridge University Press
2022
International Epidemiology Institute
2020
Tehran University of Medical Sciences
2012-2019
Cancer Institute (WIA)
1990-2019
Tenwek Hospital
2012-2018
Journal Article Nutrition Intervention Trials in Linxian, China: Supplementation With Specific Vitamin/Mineral Combinations, Cancer Incidence, and Disease-Specific Mortality the General Population Get access William J. Blot, Blot National InstituteBethesda, Md. Correspondence to : Ph.D., Biostatistics Branch, Division of Etiology, Institute, 6130 Executive Blvd., Rockville, MD 20852 Search for other works by this author on: Oxford Academic PubMed Google Scholar Jun-Yao Li, Li Chinese Academy...
Esophageal cancer incidence and mortality rates in Linxian, China are among the highest world. We examined risk factors for esophageal squamous cell carcinoma (ESCC), gastric cardia (GCC), noncardia (GNCC) a population-based, prospective study of 29,584 adults who participated Linxian General Population Trial. All participants completed baseline questionnaire that included questions on demographic characteristics, personal family history disease, lifestyle factors. After 15 years follow-up,...
A number of vitamins and minerals have been shown to influence carcinogenesis in experimental animals. In humans, epidemiologic evidence suggests that intake fruits vegetables may reduce risk esophageal other cancers. Vitamins these foods contribute the reduced cancer risk. The people Linxian, China, persistently low multiple nutrients exhibit one world's highest rates esophageal/gastric cardia cancer, with an exceptionally high dysplasia. To determine whether supplementation among persons...
Abstract Background: Cancer epidemiology articles often point out that cancer rates tend to be higher among males than females yet rarely is this theme the subject of investigation. Methods: We used Surveillance, Epidemiology and End Results program data compute age-adjusted (2000 U.S. standard population) sex-specific incidence male-to-female rate ratios (IRR) for specific sites histologies period 1975 2004. Results: The 10 cancers with largest IRR were Kaposi sarcoma (28.73), lip (7.16),...
Colonization with Helicobacter pylori is a risk factor for gastric adenocarcinoma, but the magnitude of this association and its relationship to anatomic location cancer, duration follow-up, age at diagnosis, histologic subtype, H. strain differences are less clear. We conducted prospective nested case-control study serology address these questions.Case control subjects were selected from 29,133 50- 69-year-old males recruited into Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. At...
BackgroundThe General Population Nutrition Intervention Trial was a randomized primary esophageal and gastric cancer prevention trial conducted from 1985 to 1991, in which 29 584 adult participants Linxian, China, were given daily vitamin mineral supplements. Treatment with "factor D," combination of 50 μg selenium, 30 mg E, 15 beta-carotene, led decreased mortality all causes, overall, cancer. Here, we present 10-year follow-up after the end active intervention.
Objective To determine the association of different types meat intake and associated compounds with overall cause specific mortality.Design Population based cohort study.Setting Baseline dietary data NIH-AARP Diet Health Study (prospective general population from six states two metropolitan areas in US) 16 year follow-up until 31 December 2011.Participants 536 969 AARP members aged 50-71 at baseline.Exposures Intake total meat, processed unprocessed red (beef, lamb, pork) white (poultry...
Tooth loss has previously been associated with a higher risk of cancer, heart disease, and stroke, but the role confounding by smoking remains an issue.We conducted cohort study including 29,584 healthy, rural Chinese adults who were participants in chemoprevention trial from 1986 through 1991 have followed-up 2001. We categorized tooth for each subject as less than or equal to greater median number teeth lost other subjects same age at baseline. Mortality outcomes follows: total death (n =...
In previous studies in the high risk population of Linxian, China, majority foci grade (moderate and severe) squamous dysplasia (HGD) invasive carcinoma (CA) esophagus were associated with endoscopically visible lesions that could be targeted for biopsy, but some HGD missed by routine endoscopic examination. This study examined whether spraying mucosa Lugol's iodine solution, which stains normal epithelium brown leaves unstained, improve detection delineation these lesions.Two hundred...
The very high incidence of oesophageal squamous cell carcinoma (ESCC) in Golestan Province northeastern Iran was suggested by studies the 1970s as partly due to opium use, which is not uncommon this area, but based on limited numbers. From December 2003 June 2007, we administered a validated structured questionnaire 300 ESCC cases and 571 controls, matched neighbourhood residence, age (+/-2 years), sex. We used conditional logistic regression models calculate odds ratios (ORs) 95% confidence...
Cancer registries in the 1970s showed that parts of Golestan Province Iran had highest rate oesophageal squamous cell carcinoma (OSCC) world. More recent studies have shown while rates are still high, they approximately half what were before, which might be attributable to improved socio-economic status (SES) and living conditions this area. We examined a wide range SES indicators investigate association between different components risk OSCC region.Data obtained from population-based...
Objectives To investigate the association between opium use and subsequent risk of death. Design Prospective cohort study. Setting The Golestan Cohort Study in north-eastern Iran collected detailed validated data on other exposures at baseline. Participants were enrolled January 2004 June 2008 followed to May 2011, with a follow-up success rate over 99%. 50 045 participants aged 40-75 Main outcomes Mortality, all cause major subcategories. Results 17% (n=8487) reported use, mean duration...
Previous studies have shown that oesophageal and gastric cancers are the most common causes of cancer death in Golestan Province, Iran. In 2001, we established Atrak Clinic, a referral clinic for gastrointestinal (GI) diseases Gonbad, major city eastern Golestan, which has permitted, first time this region, endoscopic localisation histologic examination upper GI cancers. Among initial 682 patients seen at 370 were confirmed histologically to cancer, including 223 (60%) squamous cell (ESCC),...
Abstract We tested the association between tooth loss and oral hygiene risk of esophageal squamous cell carcinoma (ESCC) in people living a high-risk area Iran. used case-control study pathologically confirmed ESCC cases (n = 283) controls 560) matched on sex, age, neighborhood. Subjects with had significantly more decayed, missing, or filled teeth (DMFT) median (interquartile range) 31 (23-32) compared 28 (16-32; P 0.0045). were likely than to fail practice regular (78% versus 58%). In...