A5100761364- Retinal Development and Disorders
- Renal cell carcinoma treatment
- Renal and related cancers
- Ferroptosis and cancer prognosis
- Air Quality and Health Impacts
- Cancer Cells and Metastasis
- melanin and skin pigmentation
- Climate Change and Health Impacts
- Sperm and Testicular Function
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Hydrogen Storage and Materials
- Cancer Genomics and Diagnostics
- Cutaneous Melanoma Detection and Management
- Glioma Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Neurogenesis and neuroplasticity mechanisms
- Extracellular vesicles in disease
- Photoreceptor and optogenetics research
Fudan University Shanghai Cancer Center
2025
Minhang District Central Hospital
2025
Fudan University
2021-2025
First Hospital of Shanxi Medical University
2023-2025
Shanxi Medical University
2023-2025
Lanzhou University
2019-2025
Lanzhou University Second Hospital
2019-2025
Guiyang Medical University
2013-2024
Macau University of Science and Technology
2024
Affiliated Hospital of Guizhou Medical University
2018-2024
<h3>Context</h3>Attempts to determine the clinical significance of BRCA1/2 mutations in ovarian cancer have produced conflicting results.<h3>Objective</h3>To relationships between deficiency (ie, mutation and promoter hypermethylation) overall survival (OS), progression-free (PFS), chemotherapy response, whole-exome rate cancer.<h3>Design, Setting, Patients</h3>Observational study multidimensional genomics data on 316 high-grade serous cases that were made public 2009 2010 via The Cancer...
No curative treatment exists for glioblastoma, with median survival times of less than 2 years from diagnosis. As an approach to develop immune-based therapies we sought target antigens expressed in glioma stem cells (GSCs). GSCs have multiple properties that make them significantly more representative tumors established cell lines. Epidermal growth factor receptor variant III (EGFRvIII) is the result a novel tumor-specific gene rearrangement produces unique protein approximately 30%...
Information about global and local epidemiology trends of skin cancers is limited, which increases the difficulty cutaneous cancer control.
Background Research on the association between blood lead (Pb) and lipid biomarkers have yielded inconsistent results, epidemiological studies Pb levels hyperlipidemia are scarce. The present study aimed to examine in adults from National Health Nutrition Examination Survey (NHANES). Methods A total of 43,196 participants NHANES 1999 2018 were included final analysis. Hyperlipidemia was determined based Cholesterol Education Program guidelines. Blood assessed using inductively-coupled plasma...
To gain an understanding of the outbreaks bacterial foodborne diseases and subsequent health impact, we reviewed 2447 papers from journals published in China that reported 1082 disease cases occurring between 1994 2005. Among for which etiology was determined, Vibrio parahaemolyticus caused most outbreaks, followed by Salmonella, Clostridium botulinum led to deaths. Most occurred May October, except botulinum, mainly January February. In littoral provinces, events, whereas inland largest...
In recent years, a small number of cells that have stem cell properties were identified in human gliomas called brain tumor (BTSCs), which thought to mainly contribute the initiation and development could be by surface marker CD133. However, studies indicated expression CD133 might regulated environmental conditions such as hypoxia there CD133(-) BTSCs. Genetic mouse models demonstrated some originated from transformed neural (NSCs). Therefore, we investigated CD15, for NSCs, spheres derived...
// Dong-Ge Niu 1, 2, 3, * , Fei Peng Wei Zhang 2 Zhong Guan 4 Hai-Dong Zhao 5 Jing-Lin Li 3 Kai-Li Wang Ting-Ting Yan Fei-Meng Zheng Fan Xu 6 Qian-Ni Han Gao Qing-Ping Wen Quentin Liu 1 Institute of Cancer Stem Cell, Dalian Medical University, 116044, China Sun Yat-sen University Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center Medicine, Guangzhou 510060, Department Anesthesia, The First Affiliated Hospital, Otorhinolaryngology, Memorial 510120, Breast...
Epithelial-mesenchymal transition (EMT) is a crucial process providing cancer cells with the ability to migrate and metastasize distant sites. Recently, EMT was shown be associated stem cell (CSC) phenotype chemoresistance. Twist transcription factor that regulates in various cells, including colorectal (CRC). Our study done determine role of mediating aggressive CRC. Human CRC lines were transduced retroviral construct or vector control. Migration invasion abilities determined vitro using...
Abstract Cancer stem cells (CSCs) are a major cause of tumor treatment resistance, relapse and metastasis. exhibit reprogrammed metabolism characterized by aerobic glycolysis, which is also critical for sustaining cancer stemness. However, regulation cell rewiring stemness not completely understood. Here, we report that ETV4 key transcription factor in regulating glycolytic gene expression. loss significantly inhibits the expression HK2, LDHA as well other enzymes, reduces glucose uptake...
The cell fate determination factor Dachshund was cloned as a dominant inhibitor of the hyperactive epidermal growth receptor ellipse. expression is lost in human breast cancer associated with poor prognosis. Breast tumor-initiating cells (TIC) may contribute to tumor progression and therapy resistance. Here, endogenous DACH1 reduced lines high TIC markers patient samples basal phenotype. Re-expression new formation serial transplantations vivo, mammosphere formation, proportion...
Mutations in the Retinitis Pigmentosa GTPase Regulator ( RPGR ) cause X-linked RP (XLRP), an untreatable, inherited retinal dystrophy that leads to premature blindness. localises photoreceptor connecting cilium where its function remains unknown. Here we show, using murine and human induced pluripotent stem cell models, interacts with activates actin-severing protein gelsolin, gelsolin regulates actin disassembly cilium, thus facilitating rhodopsin transport outer segments. Disease-causing...
Abstract Hyperactive EGF receptor (EGFR) and mutant p53 are common genetic abnormalities driving the progression of non–small cell lung cancer (NSCLC), leading cause deaths in world. The Drosophila gene Dachshund (Dac) was originally cloned as an inhibitor hyperactive EGFR alleles. Given importance signaling etiology, we examined role DACH1 expression development. protein mRNA reduced human NSCLC. Reexpression NSCLC colony formation tumor growth vivo via p53. Endogenous colocalized with a...
The main characteristic of tumor cell resistance is multidrug (MDR). MDR the cause decline in clinical efficacy chemotherapeutic drugs. Presently, there are several mechanisms that could MDR. Among these, one most important underlying overexpression adenosine triphosphate (ATP)-binding cassette (ABC) super-family transporters, which effectively pump out cytotoxic agents and targeted anticancer drugs across membrane. In recent years, studies found ABC transporters tyrosine kinase inhibitors...
Mutations in the cilia-centrosomal protein CEP290 are frequently observed autosomal recessive childhood blindness disorder Leber congenital amaurosis (LCA). No treatment or cure currently exists for this disorder. The Cep290