A5032936552- Cutaneous Melanoma Detection and Management
- melanin and skin pigmentation
- Cancer Immunotherapy and Biomarkers
- Skin Protection and Aging
- Nonmelanoma Skin Cancer Studies
- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Receptor Mechanisms and Signaling
- Histiocytic Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Lymphoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Circadian rhythm and melatonin
- bioluminescence and chemiluminescence research
- Melanoma and MAPK Pathways
- Immune Cell Function and Interaction
- Chemotherapy-related skin toxicity
- Synthesis and Biological Evaluation
- Infectious Disease Case Reports and Treatments
- RNA modifications and cancer
- Single-cell and spatial transcriptomics
- Phagocytosis and Immune Regulation
- Cancer and Skin Lesions
- Photodynamic Therapy Research Studies
Affiliated Hospital of Guizhou Medical University
2019-2025
Guiyang Medical University
2019-2025
Institute of Dermatology & Venereology of the Yunnan Province
2022
Guangzhou Institute of Dermatology
2022
Information about global and local epidemiology trends of skin cancers is limited, which increases the difficulty cutaneous cancer control.
Many rhodopsin-like G-protein-coupled receptors (Rh-GPCRs) are known to either promote or inhibit angiogenesis. Among these, Opsin 4 and 5 specifically involved in vascular development within the eye. 3 (OPN3), another member of Rh-GPCRs, performs a variety light-dependent light-independent functions extraocular tissue. However, its role endothelial cells angiogenesis remains unclear. Here, we found that OPN3 knockdown knockout zebrafish impairs embryonic development. Similarly, silencing...
Retinal G protein-coupled receptor (RGR), a photosensitive protein, functions as retinal photoisomerase under light conditions in humans. Cutaneous squamous cell carcinoma (cSCC) is linked to chronic ultraviolet exposure, which suggests that the photoreceptor RGR may be associated with tumorigenesis and progression of (SCC). However, expression function remain uncharacterized SCC. This study analysed normal skin lesions actinic keratosis, Bowen's disease invasive SCC respect initiation...
Abstract Background OPN3 upregulation associated with metastasis was recently described in two subtypes of lung cancers. And identified light‐independent functions epidermal melanocytes has already shown promise. However, malignant melanocytic tissues, the expression and characterization remain uncharacterized. Objectives We investigated clinico‐histopathologic features relation to acral lentiginous melanoma (ALM), which is a rare cutaneous subtype not prior sunlight exposure. Methods In...
Aging | doi:10.18632/aging.205563. Chaofen Zhao, Lina Liu, Qianyong He, Yuanyuan Li, Jianglong Feng, Yue Chen, Yuxin Xinyu Xu, Shaoyuan Zhu, Yuanmei Ye, Yajing Wen, Zhirui Zeng, Ding'an Zhou, Feng Jin
Abstract Background Emerging cell- or tissue-based evidence has demonstrated that opsin 3 (OPN3) mediates a variety of pathological processes affecting tumorigenesis, clinical prognosis, and treatment resistance in some cancers. However, comprehensive analysis OPN3 across human cancers is unavailable. Therefore, pancancer expression was performed its potential oncogenic roles were explored. Methods The characterization evaluated among 33 tumour types using Cancer Genome Atlas (TCGA) dataset....
Background: Photoreceptive proteins play critical physiological roles in human skin cells. The retinal G protein-coupled receptor (RGR) is a photoisomerase the retina, but its expression and cellular functions cells have not been reported. Objectives: We aimed to detect RGR various evaluate regulation of keratinocytes. Methods: expression, distribution, subcellular location normal epidermal keratinocytes with pathological conditions including psoriasis, seborrheic keratosis, squamous cell...
Varicella-zoster virus (VZV) causes varicella and herpes zoster (VHZ), which is endemic worldwide. Although infection with VZV represents a considerable health threat, the global, regional national burden of infection, especially probable relationship between vaccines epidemiology poorly known. We sought to estimate global spatial patterns temporal trends VHZ in 204 countries territories from 1990 2019.Numbers age-standardized rates (ASR) incidence, disability-adjusted life years (DALYs)...
The rising incidence and mortality associated with cutaneous malignant tumours highlight the importance of early diagnosis these tumors. In clinical practice, tumors are often misdiagnosed as benign skin lesions such melanocytic nevi (MN) seborrheic keratosis (SK) because their similar morphologic features. clinicopathological subtypes malignancies in East Asia populations significantly differ from those fair-skinned groups. However, studies on misdiagnoses Eastern countries lacking....
Opsin 3 (OPN3), a member of the light-sensitive, retinal-dependent opsin family, is widely expressed in variety human tissues and plays multitude light-dependent light-independent roles. We recently identified five missense variants OPN3, including p. I51T, V134A, V183I, M256I C331Y, melanocytic tumours. However, it remains unclear how these OPN3 affect protein structure function. Herein, we conducted structural functional studies variant proteins by molecular docking dynamics simulations....
In this study, we examined single nucleotide variants (SNVs) of the
Abstract Human amniotic epithelial stem cells (hAESCs) are regarded as potential alternatives to keratinocytes (KCs) used for skin wound healing. Light is an alternative approach inducing cell differentiation. Opsins (OPNs), a family of light‐sensitive, G protein‐coupled receptors, play multitude light‐dependent and light‐independent functions in extraocular tissues. However, it remains unclear whether the light sensitivity function OPNs involved light‐induced differentiation hAESCs KCs....
Ultraviolet radiation (UVR) has been recognized as a potential trigger for the transformation of benign melanocytic nevi into melanoma. However, mechanisms governing formation and progression remain poorly understood. This lack understanding is partly due to difficulty in isolating culturing nevus tissues vitro, resulting dearth robust ex vivo models nevi. Therefore, establishment reliable model imperative. Such essential elucidating pathogenesis facilitating development effective...
Retinal G protein-coupled receptor (RGR) serves a retinal photoisomerase function to mediate retinoid metabolism and visual chromophore regeneration in the human eyes.Retinoids display critical functions cell proliferation, di erentiation, apoptosis.Abnormal may contribute tumor development.However, tissues, expression of RGR remains uncharacterized.Herein, we performed analysis 620 samples from 24 types tumors by immunohistochemistry (IHC) 33 cancer Cancer Genome Atlas (TCGA), Chinese...
Abstract Epidermal melanocytes sense solar light via the opsin‐coupled signaling pathway which is involved in a range of biological functions, including regulating pigmentation, proliferation, apoptosis, and tumorigenesis. However, it remains unclear whether there are genetic variants within these opsins that affect opsin protein structure function, further melanocyte behaviors. Here, we examined single‐nucleotide (SNVs) five ( RGR, OPN1SW, OPN2, OPN4, OPN5 ) genes MM (malignant melanoma; n...
Abstract Squamous cell carcinoma of the penis is an uncommon cancer. Vascular feature on dermoscopy common in all forms invasive squamous carcinoma, and presence specific vascular features often used to aid diagnosis. Here, we reported a new dermoscopic finding—seaweed‐like pattern penis.
Langerhans cell histiocytosis (LCH) is a type of -histiocytic disorder characterized by aberrant function, differentiation or proliferation mononuclear phagocyte system cells, however, the pathogenesis not fully understood. Opsin 3 (OPN3) plays an important role in regulating function. We aimed to investigate OPN3 expression LCH and cells evaluate its possible regulation cellular function cell-like line (ELD-1). Expression paired adjacent healthy skin tissue was determined using microscopic...
Objective: To examine the antioxidant effect of low dosage insulin glargine intervention at different time in rats with delayed resuscitation after burn, order to acquire a better during following burn injury. Methods: With 10 each group, 50 male SD were assigned sham injury immediate post-burn treatment group (immediate group), 2 hours group(2 h and 6 group(6 group) random number table. Each received subcutaneous injections (1.0 U·kg-1·d-1) immediately, two six while same amount normal...