A5101607250- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
- Drug Solubulity and Delivery Systems
- Gastric Cancer Management and Outcomes
- Dendrimers and Hyperbranched Polymers
- Metastasis and carcinoma case studies
- Colorectal Cancer Surgical Treatments
- MicroRNA in disease regulation
- Inflammatory mediators and NSAID effects
- Peptidase Inhibition and Analysis
- Metal-Organic Frameworks: Synthesis and Applications
- Protease and Inhibitor Mechanisms
- Gastrointestinal Tumor Research and Treatment
- Sarcoma Diagnosis and Treatment
- RNA modifications and cancer
- Drug Transport and Resistance Mechanisms
- Chemical Synthesis and Analysis
- Cell Adhesion Molecules Research
- Colorectal and Anal Carcinomas
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer-related molecular mechanisms research
- Medical Research and Treatments
Shenyang Center for Disease Control and Prevention
2025
Linyi University
2025
North China University of Science and Technology Affiliated Hospital
2024
Gansu Provincial Hospital
2024
Gansu Provincial Maternal and Child Health Hospital
2024
China Pharmaceutical University
2016-2024
National Institute for Communicable Disease Control and Prevention
2024
University of Edinburgh
2023
Hebei Medical University
2023
Capital Medical University
2021
Chemotherapeutic efficacy can be greatly improved by developing nanoparticulate drug delivery systems (nano-DDS) with high loading capacity and smart stimulus-triggered release in tumor cells. Herein, we report a novel redox dual-responsive prodrug-nanosystem self-assembled hydrophobic small-molecule conjugates of paclitaxel (PTX) oleic acid (OA). Thioether linked (PTX-S-OA) dithioether inserted (PTX-2S-OA) are designed to respond the redox-heterogeneity tumor. Dithioether has been reported...
The tumor microenvironment (TME) plays a critical role in initiation, progression, invasion, and metastasis. Therefore, therapy that combines chemotherapeutic drugs with TME modulator could be promising route for cancer treatment. This paper reports nanoplatform self-assembled from hyaluronic acid (HA)-paclitaxel (PTX) (HA-PTX) prodrug marimastat (MATT)-loaded thermosensitive liposomes (LTSLs) (MATT-LTSLs) the dual targeting of cells. Interestingly, HA-PTX can self-assemble on both...
CAR-T cell therapy, a novel immunotherapy, has made significant breakthroughs in clinical practice, particularly treating B-cell-associated leukemia and lymphoma. However, it still faces challenges such as poor persistence, limited proliferation capacity, high manufacturing costs, suboptimal efficacy. CRISPR/Cas system, an efficient simple method for precise gene editing, offers new possibilities optimizing cells. It can increase the function of cells reduce costs. The combination...
Abstract Co-delivery of microRNAs and chemotherapeutic drugs into tumor cells is an attractive strategy for synergetic breast cancer therapy due to their complementary mechanisms. In this work, a core-shell nanocarrier coated by cationic albumin was developed simultaneously deliver miRNA-34a docetaxel (DTX) improved therapeutic effect. The co-delivery nanocarriers showed spherical morphology with average particle size 183.9 nm, they efficiently protected from degradation RNase serum....
In addition to being a physiological protective barrier, the gastrointestinal mucosal membrane is also primary obstacle that hinders oral absorption of many therapeutic compounds, especially drugs with poor permeability. order resolve this impasse, we have designed multifunctional nanomicelles based on acetylcysteine functionalized chitosan-vitamin E succinate copolymer (CS-VES-NAC, CVN), which exhibit marked bioadhesion, possess ability penetrate mucus, and enhance hydrophobic drug...
This experiment tested the hypothesis that running-induced damage to rat skeletal muscle causes changes in synthesis and degradation of basement membrane type IV collagen proteins regulating its degradation. Samples from soleus red white parts quadriceps femoris (MQF) were collected 6 h or 1, 2, 4, 7 days after downhill running. Increased β-glucuronidase activity indicated greater part MQF than soleus. In MQF, expression was upregulated at pretranslational level protein concentration...
Strong infectivity enables coronavirus disease 2019 (COVID-19) to rage throughout the world. Moreover, lack of drugs with definite therapeutic effects further aggravates spread pandemic. Remdesivir is one most promising anti-severe acute respiratory syndrome 2 (SARS-CoV-2) drugs. However, limited clinical make its effect controversial, which may result from poor accumulation and activation remdesivir in lung. Therefore, we developed lyophilized liposomes (Rdv-lips) can be reconstituted as...
Based on a non-targeted metabolomic approach, comprehensive analysis of the metabolic profiles two raspberry cultivars, Selina (TSM) and Tulameen (CSM), was conducted to explore potential for further processing these varieties.
ABSTRACT Enhanced chemical weathering is a well‐documented consequence of the warming associated with Early Cretaceous Oceanic Anoxic Event 1a. This process likely contributed to reduction greenhouse gas levels and facilitated termination event. While role enhanced silicate as terminator 1a has been established, coeval changes in inland East Asia, which far from ocean, are not well‐known. study analysed strontium‐isotope, oxygen–carbon isotope, clay mineral, elemental geochemistry shales...
The objective of this study is to compare two different dissolution-enhancing strategies, solid dispersion (SD) and micronized techniques, for improving oral absorption poorly soluble glimepiride, decide which strategy suitable its solubilization. formulation glimepiride SD was prepared by a solvent-evaporation process with povidone k-30 (PVPk30) at weight ratio 1:9 (drug:carrier). other via modified micronization technique, where premilled together lactose Lutrol F68 until the milled...
The US Food and Drug Administration's Sentinel system has developed the capability to conduct active safety surveillance of marketed medical products in a large network electronic healthcare databases. We assessed extent which newly developed, semiautomated Propensity Score Matching (PSM) tool could produce same results as customized protocol‐driven assessment, found an adjusted hazard ratio (HR) 3.04 (95% confidence interval [CI], 2.81–3.27) comparing angioedema patients initiating...
Drug-drug interactions causing severe hypoglycemia due to antidiabetic drugs is a major clinical and public health problem. We assessed whether sulfonylurea use with statin or fibrate was associated hypoglycemia. conducted cohort studies of users glyburide, glipizide, glimepiride plus within Medicaid population. The outcome validated, diagnosis-based algorithm for Among 592,872 persons newly exposed sulfonylurea+antihyperlipidemic, the incidence 5.8/100 person-years. Adjusted hazard ratios...
It is disclosed how the sizes of rod‐shaped paclitaxel‐nanosuspensions (PTX‐Ns) that are less than 500 nm affect their in vitro and vivo performances. A size reduction from to 160 enhances cellular uptake subsequent cytotoxicity, due participation caveolae‐mediated endocytosis; moreover, ability PTX‐Ns penetrate tumors well correlated with extent which caveolae pathway participates uptake, as target markedly promoted decreased nm. Also, alters performance tumor targeting. via enhanced...
AIM:To investigate the short-term benefits of laparoscopic radical gastrectomy (LARG) and open (ORG) in patients with gastric cancer. METHODS:A total 400 cancer aged ≤ 65 years who were treated at General Hospital Lanzhou Military Region enrolled.Among these, 200 underwent LARG between October 2008 August 2012 (LARG group); ORG March 2000 September (ORG group).The therapeutic two groups analyzed. RESULTS:The procedure offered significantly better to compared procedure, including less...