A5100409575- Pharmacological Effects and Assays
- Asthma and respiratory diseases
- Receptor Mechanisms and Signaling
- Neurological Disease Mechanisms and Treatments
- Inhalation and Respiratory Drug Delivery
- Peptidase Inhibition and Analysis
- Dermatology and Skin Diseases
- Advanced Drug Delivery Systems
- Neurological Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Neuropeptides and Animal Physiology
- Respiratory and Cough-Related Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Colorectal Cancer Treatments and Studies
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Drug Solubulity and Delivery Systems
- Biochemical effects in animals
- Neurobiology and Insect Physiology Research
- Multiple Myeloma Research and Treatments
- Reproductive tract infections research
- Pain Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Urticaria and Related Conditions
Shenyang Pharmaceutical University
2012-2024
Sichuan University
2023-2024
West China Hospital of Sichuan University
2023-2024
First Affiliated Hospital of Wenzhou Medical University
2023
Amgen (United States)
2023
Wenzhou Medical University
2023
Union Hospital
2021
Huazhong University of Science and Technology
2021
Wuhan Union Hospital
2021
Peking University First Hospital
2020
Transplantation of human bone marrow mesenchymal stem cells (hMSCs) stands as a potent stroke therapy, but its exact mechanism remains unknown. This study investigated the anti-apoptotic mechanisms by which hMSCs exert neuroprotective effects on cerebral ischemia. Primary mixed cultures rat neurons and astrocytes were cultured exposed to oxygen-glucose deprivation. A two-hour period "reperfusion" in standard medium normoxic conditions was allowed immediately followed and/or Bcl-2 antibody...
To establish an animal model of acute-on-chronic liver failure (ACLF) that would replicate the pathological process ACLF in humans, rats were administered porcine serum (PS) for 11 weeks. Liver fibrosis was determined by and biochemical assessments. The animals then injected with d-galactosamine (d-gal) lipopolysaccharide (LPS). survival times cirrhosis over 48 h. Other killed at 0, 4, 8 12 h after administration d-gal/LPS. injury assessed histopathological analysis indices, apoptosis...
Journal Article Workshop on In Vitro Neutralization of Chlamydia trachomatis: Summary Proceedings Get access G. I. Byrne, Byrne Reprints or correspondence: Dr. Gerald Dept. Medical Microbiology, University Wisconsin, 1300 Ave., Madison, WI 53706. Search for other works by this author on: Oxford Academic PubMed Google Scholar R. S. Stephens, Stephens Ada, Ada H. D. Caldwell, Caldwell Su, Su P. Morrison, Morrison B. Van Der Pol, Pol Bavoil, Bavoil L. Bobo, Bobo Everson, Everson ... Show more...
Abstract ADAMTS12 is a gene widely expressed in human tissues. We studied the expression level of cervical cancer tissue and its relationship with clinicopathological features. also explored function cells underlying mechanisms. found higher tissues, which was associated worse overall survival rate. The immunofluorescence assay showed that cytoplasm main site ADAMTS12. Overexpression HeLa CaSki prominently promoted cell proliferation, migration invasion. 2032 genes were correlated ADAMTS12,...
Background: To investigate the prognostic value of circulating plasma cells (CPC) and establish novel nomograms to predict individual progression-free survival (PFS) as well overall (OS) patients with newly diagnosed multiple myeloma (NDMM). Methods: One hundred ninetyone NDMM in Wuhan Union Hospital from 2017.10 2020.8 were included study. The entire cohort was randomly divided into a training ( n = 130) validation 61). Univariate multivariate analyses performed on for prediction outcomes,...
Xanthones demonstrated an array of pharmacological activities via non-covalent DNA interaction and have been widely utilized in new drug research. The introduction the polar 1,2,3-triazole ring located at C3-position xanthone has not reported thus far.In present study, a series derivatives were designed, synthesized, characterized through 1H NMR, 13C MS. methyl thiazolyl tetrazolium method was used to evaluate cytotoxic activity compounds. Furthermore, structure-activity relationship...
Drug combinations have more potential advantage of greater analgesia than monotherapy. By the combination analgesics with different mechanism, potency can be maximized while incidence adverse effects is minimized. This study was aimed to assess a possible interaction in antinociceptive between tramadol (T) and propacetamol (P) when administered against nociceptive induced by physical or chemical injury mice rats. Three series experiments were performed. The first determine P T alone acetic...
Pu-erh tea has become a focus of research due to its reported biological activities, including anti-oxidation, anti-inflammation and anti-immunosenescence. The present study was performed evaluate the potential gastroprotective function extracts against ethanol‑induced gastric mucosal damage in rats. Sprague Dawley rats were randomly divided into seven groups: A normal control, model cimetidine (0.08 g/kg) group, three Pu‑erh groups (low, moderate high‑dose; 0.50, 1.00 1.50 g/kg,...
Immune checkpoint inhibitors (ICIs) have emerged as epochal milestones in the field of anti-cancer immunotherapy. With promising clinical effectiveness, ICIs can significantly prolong overall survival patients with advanced cancer different types. Although their remarkable effectiveness has been demonstrated application, display limitations terms unique response patterns. Only a subset exhibits objective responses, while others show rapid disease progression. Considering that there is fair...
8582 Background: Tarlatamab, a BiTE molecule targeting DLL3 and CD3, is being studied in patients (pts) with extensive stage small cell lung cancer (ES-SCLC). 1 Up to 25% of pts diagnosed SCLC have brain metastases (BM) 50% or more will develop BM during the course disease. Pts ES-SCLC poor prognosis quality life. We analyzed characteristics outcomes included tarlatamab phase study (NCT03319940) who had baseline vs those did not. Methods: trial that progressed after ≥1 platinum-based regimen...
Context: Dehydroxymethylepoxyquinomicin (DHMEQ) which is originally developed as an analog of antibiotic epoxyquinomicin C a specific and potent inhibitor NF-κB has been shown to possess promising potential anti-inflammatory anti-tumor agent.Objective: This study examines DHMEQ's effect on therapeutic for atopic dermatitis (AD)-like lesions.Materials methods: AD lesions were chronically induced by the repetitive alternative application 2,4-dinitrochlorobenzene (DNCB) oxazolone (OX) ears in...
Although β2-agonists are crucial for treatment of chronic respiratory diseases, optimizing β2-agonistic activity and selectivity remains essential achieving favorable therapeutic outcomes. A structure-based molecular design workflow was employed to discover a novel class β2 agonists featuring 5-hydroxy-4H-benzo[1,4]oxazin-3-one scaffold, which potently stimulated adrenoceptors (β2-ARs). Screening the led identification compound A19 (EC50 = 3.7 pM), functioned as partial β2-agonist in HEK-293...
Previous study on racemic SPFF [2-(4-amino-3-chloro-5-trifluomethyl-phenyl)-2-tert-butylamino-ethanol hydrochloride], a novel β2-adrenoceptor agonist, has validated that it is potent, long-acting bronchodilator with relative higher selectivity. On the basis of this study, we compared pharmacological properties and its enantiomers ((−)-SPFF (+)-SPFF) in guinea pigs taking isoprenaline or salbutamol (SAB) as referenced drugs. For relaxation both normal precontracted trachea strips vitro,...