A5011344704- Nanoparticle-Based Drug Delivery
- Quantum Information and Cryptography
- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Drug Solubulity and Delivery Systems
- Dendrimers and Hyperbranched Polymers
- Drug Transport and Resistance Mechanisms
- Quantum Computing Algorithms and Architecture
- Wound Healing and Treatments
- Inhalation and Respiratory Drug Delivery
- Natural product bioactivities and synthesis
- Cytokine Signaling Pathways and Interactions
- Polymer Surface Interaction Studies
- Photonic and Optical Devices
- Dermatologic Treatments and Research
- RNA Interference and Gene Delivery
- Surfactants and Colloidal Systems
- Inflammatory Myopathies and Dermatomyositis
- Chronic Myeloid Leukemia Treatments
- Diamond and Carbon-based Materials Research
- Hair Growth and Disorders
- Curcumin's Biomedical Applications
- Islanding Detection in Power Systems
- Flavonoids in Medical Research
Nankai University
2015-2025
State Key Laboratory of Medicinal Chemical Biology
2017-2025
Tianjin International Joint Academy of Biomedicine
2024
UNSW Sydney
2022
Shenyang Pharmaceutical University
2013-2015
Hohai University
2011
Rationale: The role of SLUG in epithelial-mesenchymal transition during tumor progression has been thoroughly studied, but its precise regulation remains poorly explored. Methods: affinity purification, mass spectrometry and CO-IP were performed to identify the interaction between ubiquitin-specific protease 5 (USP5). Cycloheximide chase assays deubiquitination confirmed that effect USP5 on deubiquitin SLUG. dual-luciferase reporter chromatin immunoprecipitation employed observe direct...
// Xiao-Yu Ai 1, * , Yuan Qin 2, Hui-Jua Liu Zhan-Hong Cui 2 Meng Li Jia-Huan Yang Wei-Long Zhong Yan-Rong Shuang Chen Tao Sun Hong-Gang Zhou and Cheng 1 State Key Laboratory of Medicinal Chemical Biology College Pharmacy, Nankai University, Tianjin, China Tianjin Molecular Drug Research, International Joint Academy Biomedicine, These authors have contributed equally to this work Correspondence to: Yang, email: Cheng.yang@nankai.edu.cn Zhou, honggang.zhou@vip.126.com Keywords: apigenin; IBD;...
In addition to being a physiological protective barrier, the gastrointestinal mucosal membrane is also primary obstacle that hinders oral absorption of many therapeutic compounds, especially drugs with poor permeability. order resolve this impasse, we have designed multifunctional nanomicelles based on acetylcysteine functionalized chitosan-vitamin E succinate copolymer (CS-VES-NAC, CVN), which exhibit marked bioadhesion, possess ability penetrate mucus, and enhance hydrophobic drug...
High-purity single-photon sources (SPS) that can operate at room temperature are highly desirable for a myriad of applications, including quantum photonics and key distribution. In this work, we realize an ultra-bright solid-state SPS based on atomic defect in hexagonal boron nitride (hBN) integrated with solid immersion lens (SIL). The SIL increases the source efficiency by factor six, system is capable producing over ten million single photons per second temperature. Our results promising...
A novel redox-responsive PEG-sheddable copolymer of disulfide-linked polyethylene glycol 5000-lysine-di-tocopherol succinate (P5kSSLV) was designed and synthesized. Thin-film hydration method used to prepare DOX-loaded P5kSSLV nanomicelle. To optimize the preparation technology, we investigate effects dosage, type organic solvent, temperature time, cryoprotectant on drug-loading content, encapsulation efficiency, particle size, zeta potential. The mean size potential were determined by...
Deglycosylated azithromycin (Deg-AZM), a new transgelin agonist with positive therapeutic effects on slow transit constipation, has been approved for clinical trials in 2024. This work investigated the drug metabolism and transport of Deg-AZM to provide research data further development Deg-AZM. A combination UPLC-QTOF-MS was used obtain metabolite spectra plasma, urine, feces bile. Caco-2 cells investigate permeability whether it is potential substrate efflux transporter P-glycoprotein....
Skin fibrosis including keloids, which are characterized excessive deposition, abnormal proliferation, aggressiveness, and migration of the extracellular matrix dermal fibroblasts. TGF-β signaling is a classical pro-fibrotic pathway, it plays crucial part in occurrence progression skin fibrosis. Daidzein (Dai), an isoflavone compound, has been proved to possess anti-fibrosis effect by various inflammatory fibrotic diseases. However, little known about Dai on Therefore, we further explored...
Spherical nanoparticles as a classic delivery vehicle for anticancer drugs have been extensively investigated, but study on the shape of has received little attention until now. Here, nonspherical poly(ethylene glycol) (PEG)-stabilized bilayer nanodisk consisting 1,2-distearyl-sn-glycero-3-phosphocholine (DSPC) and PEG5000-glyceryl distearate (PEG5K-GCDS) was prepared doxorubicin delivery, called DOX-Disks. The disks were open structures, with hydrophobic discoid center built by DSPC...
There is a strong desire to develop docetaxel (DTX) formulation with good therapeutic effectiveness in view of serious adverse reactions the commercial DTX (Taxotere®). In this study, redox-responsive DTX-vitamin E prodrug was successfully formulated into liposomes drug loading 4.14% ± 0.10%. Compared liposomes, (DPLs) showed stability for 30-d shelf life and during dilution different media. vitro antitumor activity DPLs on human prostatic carcinoma PC-3 cells lung cancer A549 evaluated...
In the previous study, we have synthesized an amphiphilic copolymer of nanostructure-forming material and P-glycoprotein (P-gp) inhibitor, lysine-linked ditocopherol polyethylene glycol 2000 succinate (PLV2K). The cytotoxicty in vitro anticancer efficacy vivo after intravenous administration DOX-loaded PLV2K micelles (PLV2K-DOX) was found more effective than DOX solution (DOX-Sol). However, its performance mechanism on oral absorption doxorubicin are not well understood yet. PLV2K-DOX...
A redox‐responsive poly(ethylene glycol) (PEG)‐sheddable copolymer of disulfide‐linked PEG 5000‐lysine‐di‐tocopherol succinate (P 5k SSLV) is developed which can self‐assemble into nanomicelles in aqueous condition and trigger the rapid release encapsulated drugs within tumor cells. The reduction‐insensitive doxorubicin (DOX)‐loaded P LV LV‐DOX) are further prepared. Then head‐to‐head comparison SSLV‐DOX, LV‐DOX DOX‐Sol performed concerning vitro release, cytotoxicity, cellular uptake...
Streptococcus suis is one of the most important swine pathogens, which can cause persistent infection by forming biofilms. In this study, sub-minimum inhibitory concentration (sub-MIC) rhubarb water extracts were found to inhibit biofilm formation. Two-component signal transduction systems (TCSs), transcriptional regulators, and DNA binding proteins compared under two conditions: (1) cells treated with sub-MIC (2) untreated cells. Using an isobaric tags for relative absolute quantitation...
// Huijuan Liu 1, 2, * , Qin Tian Xiaoyu Ai Yuan 1 Zhanhong Cui Meng Li Jiahuan Yang Denghui Zhai Yanrong 3 Shuang Chen Jing Tao Sun Honggang Zhou and Cheng State Key Laboratory of Medicinal Chemical Biology College Pharmacy, Life Sciences, Nankai University, Tianjin, China 2 Tianjin Molecular Drug Research, International Joint Academy Biomedicine, These authors have contributed equally to this work Correspondence to: Yang, email: cyang66_2001@yahoo.com Zhou, honggang.zhou@vip.126.com Sun,...
Localizing text in low-light environments is challenging due to visual degradations. Although a straightforward solution involves two-stage pipeline with image enhancement (LLE) as the initial step followed by detector, LLE primarily designed for human vision instead of machine and can accumulate errors. In this work, we propose an efficient effective single-stage approach localizing dark that circumvents need LLE. We introduce constrained learning module auxiliary mechanism during training...
Fibrotic skin diseases, such as keloids, are pathological results of aberrant tissue healing and characterized by overgrowth dermal fibroblasts. Remdesivir (RD), an antiviral drug, has been reported to have pharmacological activities in a wide range fibrotic diseases. However, whether RD function on fibrosis remains unclear. Therefore, our study, we explored the potential effect mechanisms both vivo vitro . As expected, demonstrated that alleviated BLM‐induced attenuates gross weight keloid...
Introduction Deglycosylated azithromycin (Deg-AZM), a newly developed Class I drug with good therapeutic effects on slow transit constipation, is small-molecule transgelin agonist that has been approved for clinical trials in 2024. The preclinical pharmacokinetic profile of Deg-AZM was investigated to support further development. Methods A LC-MS/MS method established and validated detected the concentration various biological samples. In vivo tests such as studies rats dogs, tissue...