A5077860536- Nanoparticle-Based Drug Delivery
- Drug Transport and Resistance Mechanisms
- RNA Interference and Gene Delivery
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Nanoplatforms for cancer theranostics
- Analytical Chemistry and Chromatography
- Cancer therapeutics and mechanisms
- Cancer Treatment and Pharmacology
- Graphene and Nanomaterials Applications
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Drug-Induced Hepatotoxicity and Protection
- Dendrimers and Hyperbranched Polymers
- Protein purification and stability
- Photodynamic Therapy Research Studies
- Boron Compounds in Chemistry
- Cystic Fibrosis Research Advances
- Inhalation and Respiratory Drug Delivery
- Ion Channels and Receptors
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Amino Acid Enzymes and Metabolism
- Colorectal Cancer Treatments and Studies
- Advanced Breast Cancer Therapies
Henan University
2016-2025
Henan University Huaihe Hospital and Huaihe Clinical Institute
2024
Purdue University West Lafayette
2021
Shenyang Pharmaceutical University
2008-2017
Science and Technology Department of Sichuan Province
2011
Nanosuspensions have attracted much interest of many scientists as a new approach to deliver poorly soluble drugs because their process flexibility and special advantages such improved oral bioavailability, high drug loading, targeting capabilities so on. Recently, the manufacture processes nanosuspensions developed quickly, some methods emerged, for example, controlled precipitation, emulsion method, microemulsion method melt-emulsion method. Additionally, post-process nanosuspension has...
Apolipoprotein E4 (ApoE4) is the main genetic risk factor for Alzheimer's disease (AD), but exact way in which it causes AD remains unclear. Curcumin considered to have good therapeutic potential AD, its mechanism has not been clarified. This study aims observe effect of curcumin on ApoE4 transgenic mice and explore possible molecular mechanism. Eight-month-old were intraperitoneally injected with 3 weeks, Morris water maze test was used evaluate cognitive ability mice. Immunofluorescence...
Self-assembly prodrugs usually consist of drug modules, activation and assembly modules. The selection suitable modules to construct prodrug nanoassemblies with self-assembly stability "intelligent" is a challenge. As common module, oleic acid can provide driving force steric hindrance for self-assembly. However, the unsaturated double bond readily oxidized it affects its chemical stability. Herein, two docetaxel (DTX) were designed using disulfide bonds as different fatty acids (isostearic...
Five peptidomimetic prodrugs of didanosine (DDI) were synthesized and designed to improve bioavailability DDI following oral administration via targeting intestinal oligopeptide transporter (PepT1) enhancing chemical stability. The permeability was screened in Caco-2 cells grown on permeable supports. 5'-O-L-valyl ester prodrug (compound 4a) demonstrated the highest membrane selected as optimal target for further studies. uptake glycylsarcosine (Gly-Sar, a typical substrate PepT1) by could...
Context Acetaminophen (APAP) overdose is the leading cause of drug-induced liver injury. Bianliang ziyu, a variety Chrysanthemum morifolium Ramat. (Asteraceae), has potential hepatoprotective effect. However, mechanism not clear yet.Objective To investigate activity and ziyu flower ethanol extract (BZE) on APAP-induced rats based network pharmacology.Materials methods Potential pathways BZE were predicted by pharmacology. Male Sprague-Dawley pre-treated with (110, 220 440 mg/kg, i.g.) for...
Cancerous tumors are still a major disease that threatens human life, with tumor multidrug resistance (MDR) being one of the main reasons for failure chemotherapy. Thus, reversing MDR has become research focus medical scientists.
A redox‐responsive poly(ethylene glycol) (PEG)‐sheddable copolymer of disulfide‐linked PEG 5000‐lysine‐di‐tocopherol succinate (P 5k SSLV) is developed which can self‐assemble into nanomicelles in aqueous condition and trigger the rapid release encapsulated drugs within tumor cells. The reduction‐insensitive doxorubicin (DOX)‐loaded P LV LV‐DOX) are further prepared. Then head‐to‐head comparison SSLV‐DOX, LV‐DOX DOX‐Sol performed concerning vitro release, cytotoxicity, cellular uptake...
Tiacumicin B (1, also known as fidaxomicin or difimicin) is a marketed drug for the treatment of Clostridium difficile infections. The biosynthetic pathway 1 has been studied in Dactylosporangium aurantiacum subsp. hamdenensis NRRL 18085 and enabled identification TiaM tailoring dihalogenase. Herein we report isolation, structure elucidation, bioactivity evaluation 14 tiacumicin congeners (including 11 new ones) from tiaM-inactivated mutant. A congener, 3, with propyl group at C-7‴ aromatic...
Background: Improving poorly soluble drugs into druggability was a major problem faced by pharmaceutists. Nanosuspension can improve the of insoluble improving solubility, chemical stability and reducing use additives, which provided new approach for development application formulation. Paclitaxel (PTX) is well-known BCS class IV drug with poor solubility permeability. Also, many studies have proved that paclitaxel substrate membrane-bound efflux pump P-glycoprotein (P-gp), therefore it...
The pharmacokinetic profile of a drug can be different when delivered as nanosuspension compared with true solution, which may in turn affect the therapeutic effect drug. goal this study was to prepare itraconazole nanosuspensions (ITZ-Nanos) stabilized by an amphipathic polymer, polyethylene glycol-poly (benzyl aspartic acid ester) (PEG-PBLA), precipitation-homogenization, and ITZ-Nanos. particle size morphology were determined Zetasizer field emission scanning electron microscope (SEM),...