A5101426020- HER2/EGFR in Cancer Research
- Liver Disease and Transplantation
- Cancer therapeutics and mechanisms
- Renin-Angiotensin System Studies
- Chronic Kidney Disease and Diabetes
- COVID-19 Clinical Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Treatments and Mutations
- COVID-19 diagnosis using AI
- Radiomics and Machine Learning in Medical Imaging
- Cholesterol and Lipid Metabolism
- Lipoproteins and Cardiovascular Health
- PARP inhibition in cancer therapy
- Signaling Pathways in Disease
- Biochemical effects in animals
- Calcium signaling and nucleotide metabolism
- HIV/AIDS drug development and treatment
- DNA and Nucleic Acid Chemistry
- Sirtuins and Resveratrol in Medicine
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Non-Invasive Vital Sign Monitoring
- Drug-Induced Hepatotoxicity and Protection
- Acute Kidney Injury Research
Ningbo No. 2 Hospital
2023
Shenyang Pharmaceutical University
2014-2022
University of Chinese Academy of Sciences
2022
China Medical University
2020
Second People’s Hospital of Yibin
2020
Five peptidomimetic prodrugs of didanosine (DDI) were synthesized and designed to improve bioavailability DDI following oral administration via targeting intestinal oligopeptide transporter (PepT1) enhancing chemical stability. The permeability was screened in Caco-2 cells grown on permeable supports. 5'-O-L-valyl ester prodrug (compound 4a) demonstrated the highest membrane selected as optimal target for further studies. uptake glycylsarcosine (Gly-Sar, a typical substrate PepT1) by could...
Most of the mortality resulting from COVID-19 has been associated with severe disease. Effective treatment cases remains a challenge due to lack early detection infection.This study aimed develop an effective prediction model for severity by combining radiological outcome clinical biochemical indexes.A total 46 patients (10 severe, 36 nonsevere) were examined. To build model, set 27 and 151 nonsevere laboratory records computerized tomography (CT) collected these patients. We managed extract...
Objective To explore the correlation between neutrophil-to-lymphocyte ratio (NLR) and contrast-induced acute kidney injury (CI-AKI). develop machine-learning (ML) methods based on NLR other relevant high-risk factors to establish new effective predictive models of CI-AKI. Methods: The data 2230 patients, who underwent elective vascular intervention, coronary angiography percutaneous intervention were retrospectively collected. patients divided into a CI-AKI group non-CI-AKI group. Logistic...
Objective: The aim of this case-control study was to analyze the association between sirtuin 1 (SIRT1) single nucleotide polymorphism (SNP) and risk acute kidney injury (AKI) in Han Chinese patients with cirrhosis explore its potential mechanism. Methods: Twenty-nine AKI (AKI group) 87 non-AKI (control were recruited from a population. SNaPshot sequencing technology used for detection SNPs. Dual luciferase reporter vectors constructed co-transfected into HK-2 human proximal tubular...
To evaluate the incidence, risk factors, and outcomes of acute kidney injury (AKI) in patients with decompensated cirrhosis based on Kidney Disease: Improving Global Outcomes Clinical Practice Guideline.For this retrospective analysis, 923 inpatients were recruited between January 2013 December 2017. The patients' baseline demographics clinical information collected analyzed. Univariate multiple logistic regression analyses conducted to determine independent factors for AKI in-hospital...
Journal of the American Society Nephrology 33(11S):p 348, November 2022. | DOI: 10.1681/ASN.20223311S1348a
Zhou, Fangfang; Wang, Lailiang; Xu, Youjun; Qilin, Sheng; Zhang, Shuzhen; Zheng, Xingyue; Luo, Qun Author Information
<sec> <title>BACKGROUND</title> Most of the mortality resulting from COVID-19 has been associated with severe disease. Effective treatment cases remains a challenge due to lack early detection infection. </sec> <title>OBJECTIVE</title> This study aimed develop an effective prediction model for severity by combining radiological outcome clinical biochemical indexes. <title>METHODS</title> A total 46 patients (10 severe, 36 nonsevere) were examined. To build model, set 27 and 151 nonsevere...
Journal of the American Society Nephrology 33(11S):p 348, November 2022. | DOI: 10.1681/ASN.20223311S1348b