A5013338910- Retinoids in leukemia and cellular processes
- Glutathione Transferases and Polymorphisms
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Natural product bioactivities and synthesis
- Estrogen and related hormone effects
- Acute Myeloid Leukemia Research
- Cell death mechanisms and regulation
- Genomics, phytochemicals, and oxidative stress
- Histone Deacetylase Inhibitors Research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- RNA Interference and Gene Delivery
- Cancer therapeutics and mechanisms
- Bioactive Compounds and Antitumor Agents
- Antioxidant Activity and Oxidative Stress
- Protein Degradation and Inhibitors
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemical compounds biological activities
- Pharmacological Effects of Natural Compounds
- Synthesis and bioactivity of alkaloids
- Pharmacological Effects of Medicinal Plants
- Synthesis and Biological Evaluation
- Plant-derived Lignans Synthesis and Bioactivity
- Berberine and alkaloids research
Shenyang Pharmaceutical University
2015-2024
Icahn School of Medicine at Mount Sinai
2008-2018
University of Coimbra
2012-2014
Mount Sinai Hospital
1999-2014
Shandong University
2012-2013
New York Proton Center
2012
Tisch Cancer Institute
2012
Tisch Hospital
2012
Cancer Institute (WIA)
2012
Mount Sinai Medical Center
1996-2009
BACKGROUND: Arsenic trioxide (As 2 O 3 ) can induce clinical remission in patients with acute promyelocytic leukemia via induction of differentiation and programmed cell death (apoptosis). We investigated the effects As on a panel malignant lymphocytes to determine whether growth-inhibitory apoptotic be observed these cells at clinically achievable concentrations. METHODS: Eight lymphocytic lines primary cultures lymphoma were treated , or without dithiothreitol (DTT) buthionine sulfoximine...
Photodynamic therapy (PDT) shows a promising synergy with chemotherapy in the therapeutic outcome of malignant cancers. The minimal invasiveness and nonsystemic toxicity are appealing advantages PDT, but combination brings nonselective toxicity. We designed polymeric nanoparticle system that contains both chemotherapeutic agent photosensitizer to seek improvement for chemo-photodynamic therapy. First, address challenge efficient co-delivery, polymer-conjugated doxorubicin (PEG-PBC-TKDOX) was...
Peganumine A (1), a new dimeric β-carboline alkaloid characterized by unique 3,9-diazatetracyclo[6.5.2.01,9.03,8]pentadec-2-one scaffold, was isolated from the seeds of Peganum harmala. The structure including absolute configuration determined spectroscopic data, X-ray crystallography, ECD calculation, and CD exciton chirality approaches. Compound 1 showed moderate cytotoxic activity against MCF-7, PC-3, HepG2 cells selective effects on HL-60 with an IC50 value 5.8 μM.
By bioactivity-guided fractionation, three known steroidal glycosides, β 2-solamargine (1), solamargine ( 2), and degalactotigonin (3), were isolated from Solanum nigrum. Compounds 1 - 3 induced morphological abnormality in Pyricularia oryzae mycelia with MMDC (minimum deformation concentration) values of 63.0, 38.5, 97.2 μM, respectively. This is the first report on isolation this species cytotoxicity six cultured human solid tumor cell lines HT-29 (colon), HCT-15 LNCaP (prostate), PC-3...
Acetyl-keto-beta-boswellic acid (AKBA), a triterpenoid isolated from Boswellia carterri Birdw and serrata, has been found to inhibit tumor cell growth induce apoptosis. The apoptotic effects the mechanisms of action AKBA were studied in LNCaP PC-3 human prostate cancer cells. induced apoptosis both lines at concentrations above 10 microg/mL. AKBA-induced was correlated with activation caspase-3 caspase-8 as well poly(ADP)ribose polymerase (PARP) cleavage. increased levels death receptor (DR)...
Epoxyeicosatrienoic acids with anti-inflammatory effects are inactivated by soluble epoxide hydrolase (sEH). Both sEH and histone deacetylase 6 (HDAC6) inhibitors being developed as neuropathic pain relieving agents. Based on the structural similarity, we designed a new group of compounds inhibition both HDAC6 obtained compound
Four new triterpenoids, 6beta-hydroxy-3-oxo-11alpha,12alpha-epoxyolean-28,13beta-olide (1), 3beta,6beta-dihydroxy-11alpha,12alpha-epoxyolean-28,13beta-olide (2), 3beta,6beta-dihydroxy-11-oxo-olean-12-en-28-oic acid (3), and 3beta-hydroxy-12-oxo-13Halpha-olean-28,19beta-olide (4), five known triterpenes, 19alpha-hydroxy-3-oxo-olean-12-en-28-oic (5), 6beta-hydroxy-3-oxo-olean-12-en-28-oic (6), sumaresinolic (7), siaresinolic (8), oleanolic (9), were isolated from the resin of Styrax...
We found that bufalin, an active principle of the Chinese medicine chan'su, has selective inhibitory effects on growth various human cancer cells. In order to examine whether growth-inhibitory effect bufalin cells is associated with apoptosis, leukemia were treated bufalin. HL-60, ML1, and U937 at 10(-8) M above had condensed fragmented nuclei. Flow cytometric analysis these showed DNA smaller than G1 phase. HL-60 a ladder pattern characteristic as analyzed by agarose gel electrophoretic...
The mechanism of the cytotoxic effect boswellic acid acetate, a 1:1 mixture alpha-boswellic acetate and beta-boswellic isolated from Boswellia carterri Birdw on myeloid leukemia cells was investigated in six human cell lines (NB4, SKNO-1, K562, U937, ML-1, HL-60 cells). Morphologic DNA fragmentation assays indicated that mediated by induction apoptosis. More than 50% underwent apoptosis after treatment with 20 mug/mL for 24 hours. This apoptotic process p53 independent. levels...
Abstract The mechanism of apoptosis induced by treatment with As2O3 alone or in combination buthionine sulfoximine (BSO) was studied NB4, U937, Namalwa, and Jurkat cells. at concentrations <2 μmol/L NB4 cells Namalwa but not U937 As2O3-induced correlated increase H2O2 caspase activation without c-Jun NH2-terminal kinase (JNK). BSO (10 μmol/L) depleted the reduced form intracellular glutathione inducing synergized 1 to induce all four cell lines. This synergy JNK activation. Treatment...
Cytarabine (1-beta-d-arabinofuranosylcytosine, ara-C, 1) suffers from low oral bioavailability due to intestinal membrane permeability and poor metabolic stability, intravenous infusion is usually adopted as the clinical standard dosing administration. To develop an alternative for 1 utilize oligopeptide transporter (PepT1), a series of 5'-amino acid ester derivatives was synthesized clarify which modification most suitable increase 1. Their apical-to-basolateral across Caco-2 cells...