A5004576679- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Nanoparticle-Based Drug Delivery
- Advancements in Photolithography Techniques
- Nanocluster Synthesis and Applications
- Connexins and lens biology
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- interferon and immune responses
- Circular RNAs in diseases
- Bacillus and Francisella bacterial research
- Cancer therapeutics and mechanisms
- Drug Transport and Resistance Mechanisms
- Breast Cancer Treatment Studies
- Male Breast Health Studies
- Ion-surface interactions and analysis
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- Block Copolymer Self-Assembly
- Dielectric materials and actuators
- Electromagnetic wave absorption materials
- Cancer Mechanisms and Therapy
- Natural Compounds in Disease Treatment
Nankai University
2023-2025
Third Affiliated Hospital of Harbin Medical University
2011-2024
Qiqihar Medical University
2023-2024
Harbin Medical University
2011-2024
BACKGROUND: Arsenic trioxide (As 2 O 3 ) can induce clinical remission in patients with acute promyelocytic leukemia via induction of differentiation and programmed cell death (apoptosis). We investigated the effects As on a panel malignant lymphocytes to determine whether growth-inhibitory apoptotic be observed these cells at clinically achievable concentrations. METHODS: Eight lymphocytic lines primary cultures lymphoma were treated , or without dithiothreitol (DTT) buthionine sulfoximine...
Single crystal X-ray diffraction analysis showed a Zn–VBA with size of 2.2 nm, in line advanced lithography technology requirements. The introduction benzoic acid ligands resulted high thermal stability, good solubility, and film-forming capability.
Introduction: This study developed a pancreatic cancer targeted drug delivery system that responds to changes in acidity. The was based on iron oxide core-shell magnetic mesoporous silica nanoparticles (M-MSNs) treat through combined chemotherapy and starvation therapy. Methods: Glucose oxidase (Gox) coupled the cell surface reduce glucose availability for cells, exacerbating heterogeneity of tumor microenvironment. Reduced pH accelerated depolymerization pH-sensitive polydopamine (PDA),...
Rare-earth (RE) metals are known as industrial vitamins and show significant regulatory effects in many fields. In this work, we first demonstrated that the vitamin effect of RE can also be applied to extreme ultraviolet (EUV) lithography. Using a Sn8RE oxo cluster universal platform, different individual metal ions were successfully doped obtain series isomorphic heterometallic clusters (RE = Y, Sm, Eu, Ho, Er). Lithography experiments have shown displayed influence on technical parameters....
The advancement of integrated circuit manufacturing has continuously relied on lithography technology as a fundamental driving force. However, the development photoresists faces resolution-line edge roughness-sensitivity (RLS) trade-off, hindering simultaneous optimization. To address this issue, we propose collaborative strategy for heterogeneous isomorphism cluster with different radiation responses. Ti4M4-oxo platform [Ti4Zr4O6(OBu)4(OMc)16] (T4Z4), higher sensitivity, was applied...
The application of magnetic resonance imaging (MRI) nano-contrast agents (nano-CAs) has increasingly attracted scholarly interest owing to their size, surface chemistry, and stability. Herein, a novel T1 nano-CA (Gd(DTPA)-GQDs) was successfully prepared through the functionalization graphene quantum dots with poly(ethylene glycol) bis(amine) subsequent incorporation into Gd-DTPA. Remarkably, resultant as-prepared displayed an exceptionally high longitudinal proton relaxivity (r1) 10.90 mM-1...
The noncoding components of the genome, including miRNA, can contribute to pathogenesis gastric cancer. Their expression has been profiled in many human cancers, but there are a few published studies It is necessary identify novel aberrantly expressed miRNAs In this study, profile 1891 was analyzed using miRCURY array LNA miRNA chip from three cancer tissues and normal tissues. levels 4 were compared by real-time PCR between cancerous We found that 31 upregulated cancer<mml:math...
Individual differences in chemosensitivity and clinical outcome of non-small-cell lung carcinoma (NSCLC) patients can be influenced by host-inherited factors.We investigated the impact XRCC1 Arg194Trp, Arg280His, Arg399Gln, XPD Arg156Arg, Asp312Asn, Asp711Asp, Lys751Gln gene polymorphisms on treatment efficacy 375 NSCLC platinum-based chemotherapy.We also examined progressionfree survival overall survival.The were analyzed duplex PCR.The with 399A/A had a significantly better response to...
We aimed to assess the role of polymorphisms XRCC1 Arg194Trp, Arg399Gln, ERCC5 His1104Asp, and His46His genes on clinical outcomes advanced non-small cell lung cancer (NSCLC) patients receiving platinum-based chemotherapy regimens. A total 378 NSCLC were asked participate within 1 month after diagnosis between January 2005 2006, they followed up until November 2011. Genomic DNA four was extracted using Qiagen Blood Kit. Results showed that individuals with 399A/A 46T/T genotypes more likely...
Abstract This study developed a probe Fe 3 O 4 -Cy5.5-trastuzumab with fluorescence and magnetic resonance imaging functions that can target breast cancer high HER2 expression, aiming to provide new theoretical method for the diagnosis of early cancer. nanoparticles were combined T 2 Cy5.5 near-infrared imaging, coupled trastuzumab targeting. We characterized used transmission electron microscopy, hydration particle size, Zeta potential, UV Fourier transform infrared spectroscopy, examined...
Male breast cancer (MBC) is a rare malignancy with worse prognosis than female (FBC). Current MBC treatment strategies are based on those for FBC. However, molecular differences between and FBC respect to drug responses remain unclear. After controlling confounding factors propensity score matching (PSM), were comprehensively analyzed using many types of data: survival, immune microenvironments, sex hormone responses, sensitivity, transcriptomes, genomes, epigenomes, proteomes. Overall...
Clinically, magnetic resonance imaging (MRI) often uses contrast agents (CAs) to improve image contrast, but single-signal MRI CAs are susceptible calcification, hemorrhage, and sensitivity. Herein, iron acetylacetone gadolinium were used as raw materials synthesize a T1-T2 dual-mode gadolinium-doped oxide (GdIO) nanocluster. Moreover, endow the nanoclusters with targeting properties achieve antitumor effects, cyclic Arg-Gly-Asp (cRGD) peptide docetaxel (DTX) attached nanocluster surface,...
Percolating composites exhibiting negative permittivity have garnered considerable attention due to their promising applications in the realm of electromagnetic shielding, innovative capacitance devices, coil-less inductors, etc. Nano carbon powder/polyvinylidene fluoride (CP/PVDF) percolating were fabricated that exhibit Drude-type negative-permittivity behavior upon reaching CP percolation threshold. This phenomenon is attributed formation a plasmonic state within interconnected network,...
Protocadherin-10 (PCDH10) is a tumor suppressor gene. Its expression level downregulated by promoter methylation in certain types of human tumors. The aim the present study was to examine and status PCDH10 breast cancer cells evaluate association progression prognosis. MethyLight used detect tissues healthy tissues. Reverse transcription-quantitative polymerase chain reaction assess mRNA PCDH10, as well between clinicopathological features, along with patients' overall survival (OS)....
Increasing evidence has demonstrated that cell adhesion molecule 1/tumor suppressor in lung cancer 1 (CADM1/TSLC1) is crucially implicated various biological processes, including proliferation, apoptosis, and invasion during tumorigenesis development. However, the mechanism underlying its suppression of tumor growth metastasis melanoma remains elusive. The aim present study was to examine if CADM1/TSLC1 able induce melanoma. plasmid pcDNA3.1‑CADM1/TSLC1 transfected into A375 cells (a human...
The glioblastoma-amplified sequence (GBAS) is a newly identified gene that amplified in approximately 40% of glioblastomas. This article probes into the expression, prognostic significance, and possible pathways GBAS ovarian cancer (OC).Immunohistochemical methods were used to evaluate expression level OC its relationship with clinicopathological characteristics prognosis. Glioblastoma-amplified shRNA was designed transfect cell lines silence then detect proliferation, apoptosis, migration...