A5100389259- Natural product bioactivities and synthesis
- Microbial Natural Products and Biosynthesis
- Phytochemistry and Bioactive Compounds
- Fungal Biology and Applications
- Marine Sponges and Natural Products
- Phytochemical Studies and Bioactivities
- Phytochemical compounds biological activities
- Phytochemistry and Biological Activities
- Bioactive natural compounds
- Phytochemistry and Bioactivity Studies
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Bioactive Natural Diterpenoids Research
- Biological and pharmacological studies of plants
- Phytochemicals and Antioxidant Activities
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Plant biochemistry and biosynthesis
- Plant Pathogens and Fungal Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Synthesis of Organic Compounds
- Chromatography in Natural Products
- Seaweed-derived Bioactive Compounds
- Chemical synthesis and alkaloids
- Advances in Cucurbitaceae Research
Shenyang Pharmaceutical University
2015-2024
Washington State University Spokane
2024
Guangxi Normal University
2017-2020
Sichuan Agricultural University
2020
Changsha Normal University
2020
Hunan Normal University
2020
Hunan Provincial People's Hospital
2020
Harbin Medical University
2018-2019
Kyoto Pharmaceutical University
2010
Peganumine A (1), a new dimeric β-carboline alkaloid characterized by unique 3,9-diazatetracyclo[6.5.2.01,9.03,8]pentadec-2-one scaffold, was isolated from the seeds of Peganum harmala. The structure including absolute configuration determined spectroscopic data, X-ray crystallography, ECD calculation, and CD exciton chirality approaches. Compound 1 showed moderate cytotoxic activity against MCF-7, PC-3, HepG2 cells selective effects on HL-60 with an IC50 value 5.8 μM.
This study was to the antitumor effect of lonchocarpin (34) from traditional herbal medicine Pongamia pinnata (L.) Pierre and reveal underlying mechanism. The cytotoxic activities were evaluated in 10 lung cancer cell lines it exhibited 97.5% activity at a dose 100 μM H292 line. A field-based quantitative structure-activity relationship (3D-QSAR) 37 flavonoids P. also performed, results obtained showed that hydrophobic interaction could be crucial factor for lonchocarpin. Molecular docking...
Twenty compounds, including 14 new α-acid derivatives, a chromone, and five known were identified from the pistillate inflorescence of Humulus lupulus (hops), their structures elucidated via physical data analysis. The absolute configurations derivatives 1–11b determined by comparing computed experimental electronic circular dichroism spectra using TDDFT NMR spectroscopic data. A putative biosynthetic pathway for components was deduced. Their antineuroinflammatory effects assayed...
A phytochemical investigation of the aqueous EtOH extract Bletilla striata tubers afforded 34 phenanthrene and 9,10-dihydrophenanthrene derivatives, including four new compounds, 1–4. These compounds were identified using physicochemical analyses various spectroscopic methods. Twelve these resolved into their enantiomers, absolute configurations determined by comparison experimental calculated ECD spectra. The antineuroinflammatory activities evaluated measuring inhibition nitric oxide...
Scope In the present study, effect of pterostilbene on β‐amyloid 1‐42 (Aβ ) induced cognitive impairment in mice is investigated and explored its possible mechanism action. Methods results The behavior show that alleviated Aβ ‐induces dysfunction assessed using Y‐maze test, novel object recognition task, Morris water maze passive avoidance test. Pterostilbene alleviates neuron loss accumulation reactive oxygen species treated mouse brain. Additionally, promotes nuclear factor‐E2 p45‐related...
The study demonstrates the mechanism of pterostilbene alleviating cerebral ischemia and reperfusion injury in rats may associate with inhibition ROS/NF-κB-mediated inflammatory pathway.
The ethyl acetate and 1-butanol soluble fractions of the roots Pfaffia glomerata were found to show inhibitory effects on melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells. From fractions, we isolated a new noroleanane-type triterpene, pfaffianol A, its glycosides, pfaffiaglycosides A B, ecdysterone-type sterol C, D, E, together with eight known constituents. structures constituents determined basis physicochemical chemical evidence. Among them, (IC50=44 μM) pfaffoside C...
Glycyrrhetinic acid (GA) is one of the main components for traditional medicine licorice, which can synchronize and promote effects other medicines in prescription. In this paper we found GA could IEC-6 cell proliferation, rescue proliferative inhibition caused by DFMO, decrease apoptotic rate, reverse delay restitution after wounding DMFO cells via HuR. To be noted, failed to proliferation suppress apoptosis silencing HuR siRNA cells. Furthermore, with model small intestinal organoids...
Alzheimer's disease (AD) is the most common type of age-related dementia. Inhibition butyrylcholinesterase (BChE) emerge as an effective therapeutic target for AD. A series new substituted acetamide derivatives were designed, synthesized and evaluated their ability to inhibit BChE. The bioassay results revealed that several compounds displayed attractive inhibition against BChE). Among them, compound 8c exhibited highest BChE with IC50 values 3.94 μM. Lineweaver Burk plot indicated acted a...
The dissolvable microneedles loaded with cedrol based on flexible backing were developed to deliver directly and continuously the dermis, where drug concentration in hair follicle can be increased locally.The tip-layer matrix solution was prepared by mixing polyvinylpyrrolidone K25 (PVP K25), pedestal aqueous hyaluronic acid. cedrol-loaded (cedrol-DMNs) under vacuum conditions. mechanical properties, pig skin penetration efficiency, vitro cutaneous permeation test, amount of receptor chamber...
The separation and epimerization of a pair unusual spiroaminal derivatives isolated from marine-derived fungus <italic>Paraconiothyrium sporulosum</italic> YK-03.
Six new (1–6) and two known (7, 8) alkaloids that were chemically inseparable geometrical isomers (two present in a 1:1 ratio for 1–4 6 1:3 5, 7, identified from Stephania cepharantha. Their structures absolute configurations determined by spectroscopic data analyses comparison of their experimental calculated ECD spectra. Moreover, using NOE correlations DFT-based calculations, the NMR each isomer 1–6 assigned. The biological evaluation 1–8 showed 5 have stronger inhibitory effects (IC50...