A5100318444- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Bioactive Natural Diterpenoids Research
- Phytochemicals and Antioxidant Activities
- Traditional Chinese Medicine Analysis
- Liver Disease Diagnosis and Treatment
- Phytochemical Studies and Bioactivities
- Traditional and Medicinal Uses of Annonaceae
- Phytochemistry and Bioactive Compounds
- Plant biochemistry and biosynthesis
- Computational Drug Discovery Methods
- Essential Oils and Antimicrobial Activity
- Biological Activity of Diterpenoids and Biflavonoids
- Plant-based Medicinal Research
- Marine Sponges and Natural Products
- Ginseng Biological Effects and Applications
- Phytochemical compounds biological activities
- RNA modifications and cancer
- Protein Tyrosine Phosphatases
- Liver physiology and pathology
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Galectins and Cancer Biology
- Microbial Natural Products and Biosynthesis
Toho University
2016-2025
Qingdao University
2018-2025
Affiliated Hospital of Qingdao University
2018-2025
Korea Institute of Oriental Medicine
2017-2025
Deyang Stomatological Hospital
2025
Xinjiang Uygur Autonomous Region Disease Prevention and Control Center
2025
Hangzhou First People's Hospital
2003-2025
Second Affiliated Hospital of Zhejiang University
2023-2025
South China Agricultural University
2020-2025
Chinese Research Academy of Environmental Sciences
2022-2025
Autophosphorylated growth factor receptors provide binding sites for the src homology 2 domains of intracellular signaling molecules. In response to epidermal (EGF), activated EGF receptor binds a complex containing protein GRB2 and Ras guanine nucleotide-releasing Sos, leading activation pathway. We have investigated whether platelet-derived (PDGF) GRB2-Sos. contrast with receptor, does not bind PDGF directly. Instead, stimulation induces formation GRB2; 70-, 80-, 110-kDa...
There is an urgent need for a vaccine that effective against the 2009 pandemic influenza A (H1N1) virus.
Mitochondrial disorders are highly heterogeneous conditions characterized by defects of the mitochondrial respiratory chain. Pharmacological activation biogenesis has been proposed as an effective means to correct biochemical and ameliorate clinical phenotype in these severely disabling, often fatal, disorders. Pathways related targets Sirtuin1, a NAD+-dependent protein deacetylase. As NAD+ boosts activity Sirtuin1 other sirtuins, intracellular levels play key role homeostatic control...
Summary Selenite is a predominant form of selenium (Se) available to plants, especially in anaerobic soils, but the molecular mechanism selenite uptake by plants not well understood. ltn1 , rice mutant previously shown have increased phosphate (Pi) uptake, was found exhibit higher than wild‐type both concentration‐ and time‐dependent assays. Respiratory inhibitors significantly inhibited wildtype mutant, indicating that coupled with H + energy‐dependent. greatly enhanced under Pi‐starvation...
It is shown that the parity game can be solved in quasipolynomial time. The parameterised - with n nodes and m distinct values (aka colours or priorities) proven to class of fixed parameter tractable (FPT) problems when over m. Both results improve known bounds, from runtime nO(√n) O(nlog(m)+6) an XP-algorithm O(nΘ(m)) for FPT-algorithm O(n5)+g(m), some function g depending on only. As application it coloured Muller games decided time O((mm · n)5); also this bound cannot improved O((2m n)c),...
Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population that plays crucial role in remodeling the tumor microenvironment (TME). Here, through integrated analysis of spatial and single-cell transcriptomics data across six common cancer types, we identified four distinct functional subgroups CAFs described their distribution characteristics. Additionally, RNA sequencing (scRNA-seq) from three additional types two newly generated scRNA-seq datasets rare namely...
We evaluated the in vivo fate and physiological behavior of quantum dots (QDs) Caenorhabditis elegans by GFP transfection, fluorescent imaging, synchrotron radiation based elemental speciation techniques. The situ metabolism degradation QDs alimentary system long-term toxicity on reproduction are fully assessed. This work highlights utility C. model as a multiflexible platform to allow noninvasively imaging monitoring consequences engineered nanomaterials.
p53, circRNAs and miRNAs are important components of the regulatory network that activates EMT program in cancer metastasis. In prostate (PCa), however, it has not been investigated whether how p53 regulates by miRNAs. Here we show a Amotl1-derived circRNA, termed circAMOTL1L, is downregulated human PCa, decreased circAMOTL1L facilitates PCa cell migration invasion through downregulating E-cadherin upregulating vimentin, thus leading to progression. Mechanistically, demonstrate serves as...
Plant samples of Cardamine hupingshanesis (Brassicaceae), Ligulariafischeri (Ledeb.) turcz (Steraceae) and their underlying top sediments were collected from selenium (Se) mine drainage areas in Enshi, China. Concentrations total Se measured using Hydride Generation-Atomic Fluorescence Spectrometry (HG-AFS) speciation determined liquid chromatography/UV irradiation-hydride generation-atomic fluorescence spectrometry (LC-UV-HG-AFS). The results showed that C. could accumulate to 239±201 mg/kg...
Recently, long non-coding RNAs (lncRNAs) have been shown to play important roles in human cancer biology. The purpose of this study was assess the biological role lncRNA H19 non-small-cell lung (NSCLC). Quantitative reverse transcription PCR (qRT-PCR) used detect expression tumor tissues and corresponding non-tumor NSCLC from 70 patients. higher positively correlated with advanced tumor-node-metastasis (TNM) stage size. Multivariate analyses found that could serve as an independent...
MmpL3, an essential transporter involved in the export of mycolic acids, is proposed target a number antimycobacterial inhibitors under development. Whether MmpL3 serves as direct these compounds, however, has been called into question after discovery that some them dissipated proton motive force from which MmpL transporters derive their energy. Using combination vitro and whole-cell-based approaches, we here provide evidence five structurally distinct inhibitor series, three impact...
The rapid development of bioinformatics tools has recently broken through the bottleneck in natural products research. These advances have enabled researchers to rapidly separate and efficiently target discover previously undescribed molecules. Among these advances, tandem mass spectrometry molecular networking is a promising method for de-replicating complex mixtures, thus leading an accelerated revolution “art isolation” field. In this review we describe current networking-based metabolite...
Background: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disease primarily characterized by insufficient insulin secretion or reduced sensitivity in the body's cells, leading to persistently high blood glucose levels. Ganoderma lucidum triterpenoids, as important secondary metabolites of lucidum, have shown preliminary potential efficacy treatment T2DM according existing research. However, due structural complexity and diversity these triterpenoid compounds, well intricate...