A5101808990- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Food Quality and Safety Studies
- Intracranial Aneurysms: Treatment and Complications
- Meat and Animal Product Quality
- Liver Disease and Transplantation
- Inflammatory mediators and NSAID effects
- Seaweed-derived Bioactive Compounds
- Osteoarthritis Treatment and Mechanisms
- Liver Disease Diagnosis and Treatment
- Microbial Metabolites in Food Biotechnology
- Polysaccharides and Plant Cell Walls
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Protein Hydrolysis and Bioactive Peptides
- Medical Imaging and Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Clinical Nutrition and Gastroenterology
- Aquaculture Nutrition and Growth
- Nutrition and Health in Aging
- Biological Stains and Phytochemicals
- Food Industry and Aquatic Biology
- Parkinson's Disease Mechanisms and Treatments
- Traditional Chinese Medicine Analysis
- GDF15 and Related Biomarkers
Capital Medical University
2006-2025
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2022-2025
Pukyong National University
2017-2025
Hunan University of Traditional Chinese Medicine
2022-2025
Chinese Academy of Sciences
2025
Beijing YouAn Hospital
2024-2025
National Institute of Biological Sciences, Beijing
2024
Aerospace Center Hospital
2023
First Hospital of Jilin University
2020-2023
Jilin University
2020-2023
<b>Objective: </b> To test whether symptomatic severe intracranial atherosclerotic stenosis was associated with a higher subsequent stroke risk than moderate after elective angioplasty balloon-expandable stent and to explore which factors were the stroke. <b>Methods: Between September 2001 June 2005, there 220 stenoses in 213 patients undergoing stenting at our institute. Of these stenoses, 126 121 ≥70% 94 92 50% 69% stenoses. Primary endpoints included lesion-related ischemic stroke, brain...
Hepatocellular carcinoma (HCC) is one of the important types liver cancer. LncRNA an regulatory factor that regulates many biological processes such as tumor cells during tumorigenesis and metastasis. LINC00346 has been associated with various cancer, but its role mechanism in HCC remain unclear. In our study, we found LINC00356-miR-199a-3p-CDK1/CCNB1 axis through bioinformatics analysis. The expressions LINC00356, miR-199a-3p, CDK1, CCNB1 normal hepatocytes were determined by qRT-PCR WB....
To explore the mechanism by which histone deacetylase 1 (HDAC1) regulates steroid-induced apoptosis of mouse osteocyte-like MLO-Y4 cells. MLY-O4 cells were treated with 400 nmol/L trichostatin A (TSA) or mmol/L dexamethasone for 24 h transfected a HDAC1-overexpressing vector prior to TSA treatment. The changes in expressions HDAC1, SP1, cleaved caspase-3 and Bax, SP1 acetylation level, cell proliferation, examined. interaction between HDAC1 was determined immunoprecipitation assay Western...
<b>Objective: </b> To study the frequency, clinical course, and functional outcome of perforator stroke (PS) resulting from elective stenting symptomatic intracranial stenosis. <b>Methods: Between September 2001 November 2004, 169 consecutive patients with 181 stenoses underwent procedure at our institute. The preoperative infarct adjacent to stenotic segment (PIAS) on MRI was evaluated blindly. Patients who developed PS after were enrolled. Each patient assessed by an experienced...
<b><i>Purpose:</i></b> Current studies on endovascular intervention for intracranial atherosclerosis select patients based luminal stenosis. Coronary demonstrated that fractional flow measurements assess ischemia better than anatomical stenosis and can guide patient selection intervention. We similarly postulated be used to ischemic stroke risk. <b><i>Methods:</i></b> This was a feasibility study the technical use safety of applying pressure...
Osteoarthritis (OA) is a common degenerative disease with few treatments. In traditional Chinese medicine (TCM), Radix Angelicae biseratae (RAB) commonly used to treat OA. Nodakenin (Nod) one main coumarin active component in RAB and exhibits anti-inflammatory, anti-oxidative, anti-apoptotic effects. Reactive oxygen species (ROS) produced by mitochondria play vital role the pathogenesis of We hypothesized that Nod might ameliorate cartilage degradation inflammatory responses regulating...
As life expectancy increases, Osteoarthritis (OA) is becoming a more frequently seen chronic joint disease. The main characteristics of OA are loss articular cartilage, subchondral bone sclerosis, and synovial inflammation. Baicalein (Bai), traditional Chinese medicine extracted from Scutellaria baicalensis Georgi, has been demonstrated to exert notable anti-inflammatory effects in previous studies, suggesting its potential effect the treatment OA. In this study, we first predicted action...
Seventy-nine consecutive patients with symptomatic atherosclerotic stenosis ≥ 50% of intracranial vertebrobasilar artery (VBA) were treated by elective stenting. There five strokes within 30 days, and three in the VBA territory after days (mean 812 days). The annual stroke rate (including any death days) was 4.6%. At last follow-up time, 73 independent (modified Rankin scale grade ≤ 2). outcome compares favorably medical therapy.
To retrospectively evaluate the cerebrovascular complications from elective stent placement for symptomatic intracranial stenosis and to explore preliminarily which factors are associated with complications.Institutional ethics committee approval was obtained, waiver of informed consent. Records were reviewed 181 consecutive procedures in 169 patients (mean age, 51.8 years; 142 male 27 female patients) more than 50% diameter reduction. Complications evaluated. Fisher exact or chi(2) tests...
Thrombelastography (TEG) is widely used for the measurement of platelet function. However, few studies have investigated TEG parameters in patients receiving extracranial or intracranial artery stenting ischemic cerebrovascular disease. This study sought to describe association before procedure with post-procedural events after stenting.Patients whom was performed stenosis (70-99%) were recruited into study. Blood samples obtained assess function stenting. The primary endpoint stroke...
Background: Knee osteoarthritis (KOA), a chronic degenerative disease, is mainly characterized by destruction of articular cartilage and inflammatory reactions. At present, there lack economical effective clinical treatment. Zhuifeng Tougu (ZFTG) capsules have been clinically approved for treatment OA as they relieve joint pain manifestations. However, the mechanism ZFTG in KOA remains unknown. Purpose: This study aimed to investigate effect on TLR4/MyD88/NF-κB signaling pathway its...
Sarcopenia is common in patients with liver cirrhosis and an independent predictor of multiple clinical outcomes. Most studies to date have used a static assessment sarcopenia. However, there very limited data evaluating the temporal course muscle area cirrhosis. To bridge this gap studies, we performed longitudinal analysis evaluate impact changes sarcopenia for cirrhotic patients.
This patient was an elderly with abdominal distension and shortness of breath. According to relevant examinations, his condition initially considered be related cirrhosis, but pathological biopsy confirmed the diagnosis noncirrhotic portal hypertension unknown etiology. The vein pressure significantly reduced after transjugular intrahepatic portosystemic shunt (TIPS). Nevertheless, relief hydrothorax ascites not significant, numbness in both lower limbs gradually worsened. POEMS syndrome...