A5067529047- Hepatitis B Virus Studies
- Sirtuins and Resveratrol in Medicine
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Lignin and Wood Chemistry
- Endoplasmic Reticulum Stress and Disease
- Mosquito-borne diseases and control
- Immunotherapy and Immune Responses
- Traditional Chinese Medicine Analysis
- Liver Diseases and Immunity
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery
- Mitochondrial Function and Pathology
- Natural product bioactivities and synthesis
- Nanoplatforms for cancer theranostics
- Systemic Sclerosis and Related Diseases
- Circular RNAs in diseases
- Immune cells in cancer
- Herpesvirus Infections and Treatments
- Catalysis for Biomass Conversion
- Biofuel production and bioconversion
- Autoimmune Bullous Skin Diseases
- Antimicrobial Resistance in Staphylococcus
First Affiliated Hospital of Shihezi University Medical College
2025
Harvard University
1994-2025
Jilin University
2008-2025
Shenzhen University
2025
First Hospital of Jilin University
2008-2025
Tianjin Medical University General Hospital
2024-2025
South China Agricultural University
2023-2024
Shanghai Chest Hospital
2023-2024
Shanghai Jiao Tong University
2016-2024
Shandong University
2024
Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2 and has spread across the globe. a highly infectious virus with no vaccine or antiviral therapy available to control pandemic; therefore, it crucial understand mechanisms of viral pathogenesis host immune responses SARS-CoV-2. new member betacoronavirus genus like other closely related viruses including SARS-CoV Middle East respiratory syndrome coronavirus (MERS-CoV). Both MERS-CoV have serious outbreaks epidemics in past eighteen...
ABSTRACT Chronic hepatitis B virus (HBV) infection is a major risk factor for liver cirrhosis and hepatocellular carcinoma. Nevertheless, the molecular mechanism of HBV replication remains elusive. SIRT1 class III histone deacetylase that structure component cccDNA minichromosome. In this study, we found by using microarray-based gene expression profiling analysis was upregulated in HBV-expressing cells. Gene silencing significantly inhibited DNA replicative intermediates, 3.5-kb mRNA, core...
Abstract Purpose: To characterize the functional role of SIRT6 in hepatocellular carcinoma (HCC). Experimental Design: The expression 60 paired paraffin-embedded HCC tissues and adjacent nontumoral liver was examined by immunohistochemistry. 101 frozen analyzed Western blotting analysis qPCR. biologic consequences overexpression knockdown cell lines were studied vitro vivo. Results: frequently upregulated clinical samples, its highly associated with tumor grade (P = 0.02), size vascular...
Highlights•CRISPR screens identify 92 GSC-specific factors linked to ZIKV infection•Integrin αvβ5 mediates internalization into hNSCs providing two drug candidates•Integrin expression correlates with susceptibility and neurotropism•Inhibition of alleviates ZIKV-induced pathology in mouse brainSummaryWe perform a CRISPR-Cas9 genome-wide screen glioblastoma stem cells integrin as an factor for Zika virus (ZIKV). Expression is correlated various tropism developing human cerebral cortex. A...
Abstract Background: Recent genome‐wide association studies found that genetic polymorphisms near the IL28B gene is strongly associated with sustained viral response and spontaneous clearance in chronically infected hepatitis C patients. Aims: We aimed to evaluate effects of variations on B virus (HBV) infection a Chinese Han population explore between susceptibility infection, clearance, disease progression, load liver inflammation. Methods: determined three single ( rs12979860, rs12980275...
Abstract N 6 ,2′- O -dimethyladenosine (m Am) is an abundant RNA modification located adjacent to the 5′-end of mRNA 7-methylguanosine 7 G) cap structure. m A methylation on 2′- -methylated at 5′-ends mRNAs catalyzed by methyltransferase Phosphorylated CTD Interacting Factor 1 (PCIF1). The role Am and function PCIF1 in regulating host–pathogens interactions are unknown. Here, we investigate dynamics reprogramming host methylome during HIV infection. We show that infection induces a dramatic...
Abstract Adenosine N6‐methylation (m6A) and N6,2′‐O‐dimethylation (m6Am) are regulatory modifications of eukaryotic mRNAs. m6Am formation is catalyzed by the methyl transferase phosphorylated CTD‐interacting factor 1 (PCIF1); however, pathophysiological functions this RNA modification PCIF1 in cancers unclear. Here, we show that expression upregulated colorectal cancer (CRC) negatively correlates with patient survival. CRISPR/Cas9‐mediated depletion human CRC cells leads to loss cell...
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be a major health problem worldwide. Due the fast emergence of SARS-CoV-2 variants, understanding molecular mechanisms viral pathogenesis and developing novel inhibitors are essential urgent. Here, we investigated potential roles N 6 ,2′- O -dimethyladenosine (m A m ), one most abundant modifications eukaryotic messenger ribonucleic acid (mRNAs), in infection human cells. Using genome-wide -exo-seq, RNA...
Abstract Eastern equine encephalitis virus (EEEV) is the most virulent alphavirus that infects humans, and many survivors develop neurological sequelae, including paralysis intellectual disability. Alphavirus spike proteins comprise trimers of heterodimers glycoproteins E2 E1 mediate binding to cellular receptors fusion host cell membranes during entry. We recently identified very-low density lipoprotein receptor (VLDLR) apolipoprotein E 2 (ApoER2) as for EEEV a distantly related alphavirus,...
Western equine encephalitis virus (WEEV) is an arthropod-borne (arbovirus) that frequently caused major outbreaks of in humans and horses the early twentieth century, but frequency has since decreased markedly, strains this alphavirus isolated past two decades are less virulent mammals than 1930s 1940s
The main objective of this study is to evaluate the influence exosomes derived from endothelial progenitor cells (EPC-Exo) on neointimal formation induced by balloon injury in rats. Furthermore, aims investigate potential EPC-Exo promote proliferation, migration, and anti-apoptotic effects vascular (VECs) vitro. underlying mechanisms responsible for these observed will also be thoroughly explored analyzed. Endothelial (EPCs) was isolated aseptically Sprague-Dawley (SD) rats cultured complete...
The stem-cell leukemia (SCL, also known as TAL1) gene encodes a basic helix-loop-helix transcription factor that is essential for the initiation of primitive and definitive hematopoiesis, erythrocyte megakarocyte differentiation, angiogenesis, astrocyte development. Here we report zebrafish produces, through an alternative promoter site, novel truncated scl (tal1) isoform, scl-beta, which manifests temporal spatial expression distinct from previously described full-length scl-alpha....
A liposomal delivery system with a high efficiency of accumulation in tumor tissue and then transportation the cargo into cells was developed here evaluated via systemic administration. 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol)2000 (DSPE-PEG2000)-TAT protective DSPE-PEG2000 modified liposomes possessing good stability 50% FBS (fetal bovine serum) uptake were used as basic formulation (TAT-SL; SL = stealth liposome), longer cysteine (Cys)-cleavable PEG5000...
Adefovir dipivoxil treatment has significantly improved the outcome of chronic hepatitis B virus (HBV) infection. However, it remains largely unknown how immune system responds to treatment. Chronic HBV patients were treated with adefovir and examined for serum DNA loads, cytokines, T helper (Th1) 2 (Th2) cytokine producing cells during 104 weeks Th1/Th2 cytokines lower in as compared normal individuals. led increase levels association decline HVB load. In contrast, remained one patient...
Background T follicular helper (TFH) cells are a special subpopulation of and can regulate humoral immune responses. This study examined whether the frequency CD4+CXCR5+ TFH could be associated with active immunity in chronic hepatitis B (CHB) patients. Methodology Findings The frequencies peripheral blood cells, inducible cell costimulator (ICOS), and/or programmed death 1 (PD-1) positive immune-active (IA), immune-tolerant (IT) CHB, healthy controls (HC) were characterized by flow...
Background and aim:The prevalence of the hepatitis B virus (HBV) is higher in adults than children.We determined seroepidemiology HBV infection an adult population JiLin, China, to guide effective preventive measures.Methods: A cross-sectional serosurvey was conducted throughout China.A total 3833 people selected demographic behavioral information gathered.Serum samples were tested for markers liver enzymes. Results:The surface antigen (HBsAg), antibody (anti-HBs), e (HBeAg), HBeAg...
Background/Aim The hepatitis B virus (HBV) infection is accompanied by the induction of oxidative stress, especially mediated HBV X protein (HBx). Oxidative stress has been implicated in a series pathological states, such as DNA damage, cell survival and apoptosis. However, host factor which cells protect themselves under this poorly understood. Methodology/Principal Findings In study, we first confirmed that significantly induced stress. Moreover, viral HBx plays major role HBV....
Hepatocellular carcinoma (HCC) is one of the important types liver cancer. LncRNA an regulatory factor that regulates many biological processes such as tumor cells during tumorigenesis and metastasis. LINC00346 has been associated with various cancer, but its role mechanism in HCC remain unclear. In our study, we found LINC00356-miR-199a-3p-CDK1/CCNB1 axis through bioinformatics analysis. The expressions LINC00356, miR-199a-3p, CDK1, CCNB1 normal hepatocytes were determined by qRT-PCR WB....
The mitochondrion is one of the most important cellular organelles, and many drugs work by acting on mitochondria. Curcumin (Cur)-induced apoptosis HepG2 in liver cancer cells closely related to function inhibiting However, mitochondrion-targeting curcumin delivery system was rarely been reported. It develop a high-efficiency vector that can deliver into mitochondria directly. Here, special based triphenylphosphine bromide (TPP)-chitosan-g-poly-(N-3-carbobenzyloxy-l-lysine) (CZL) with TPP...
Abstract After decades of inactivity throughout the Americas, western equine encephalitis virus (WEEV) recently re-emerged in South America, causing a large-scale outbreak humans and horses. WEEV binds protocadherin 10 (PCDH10) as receptor; however, nonpathogenic strains no longer bind human or PCDH10 but retain ability to avian receptors. Highly virulent can also very low-density lipoprotein receptor (VLDLR) apolipoprotein E 2 (ApoER2) alternative Here, by determining cryo-electron...
<title>Abstract</title> <bold>Background</bold>: Interstitial lung disease (ILD) and pulmonary sarcoidosis are common respiratory diseases that difficult to diagnose costly treat. Adolescents young adults (AYAs) aged 15–39 years frequently overlooked in global burden estimates despite their unique epidemiological societal implications. Comprehensive lacking. To address this gap, we analysed the results of Global Burden Disease Study (GBD) 2019, focusing on Disability-Adjusted Life Years...