A5101951143- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Hepatitis C virus research
- Liver Disease and Transplantation
- Global Health Care Issues
- Sleep and Wakefulness Research
- Organ Transplantation Techniques and Outcomes
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Sirtuins and Resveratrol in Medicine
- Obstructive Sleep Apnea Research
- Renal and related cancers
- RNA Research and Splicing
- Microbial metabolism and enzyme function
- Diet, Metabolism, and Disease
- Genetics and Neurodevelopmental Disorders
- Air Quality Monitoring and Forecasting
- Autophagy in Disease and Therapy
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Lipid metabolism and disorders
- Pancreatic function and diabetes
- Cancer Mechanisms and Therapy
Chongqing Medical University
2014-2025
Affiliated Hospital of Youjiang Medical University for Nationalities
2025
Ministry of Ecology and Environment
2024
Nanjing Institute of Environmental Sciences
2024
Shanghai Jiao Tong University
2024
Wuhan University of Science and Technology
2024
Chongqing Public Health Medical Center
2014-2023
Sichuan University
2023
Nanjing Medical University
2014-2023
Shandong University
2021-2023
Effects of a specially designed aerobic dance routine on mild cognitive impairment Yi Zhu,1,* Han Wu,2,* Ming Qi,3 Sheng Wang,4 Qin Zhang,1 Li Zhou,1 Shiyan Wang,5 Wei Wang,6 Ting Wu,6 Xiao,7 Siyu Yang,8 Hong Chen,9 Ling Zhang,4 Kathryn Chu Zhang,10 Jinhui Ma,11,12 Tong Wang1 1Rehabilitation Department, The First Affiliated Hospital Nanjing Medical University, Nanjing, Jiangsu, China; 2Rehabilitation Drum Tower Hospital, the School at 3Radiology 4Rehabilitation Suzhou Science and Technology...
Abstract Purpose: To characterize the functional role of SIRT6 in hepatocellular carcinoma (HCC). Experimental Design: The expression 60 paired paraffin-embedded HCC tissues and adjacent nontumoral liver was examined by immunohistochemistry. 101 frozen analyzed Western blotting analysis qPCR. biologic consequences overexpression knockdown cell lines were studied vitro vivo. Results: frequently upregulated clinical samples, its highly associated with tumor grade (P = 0.02), size vascular...
Hepatitis B virus (HBV) infection remains a major health problem worldwide. Maintenance of the covalently closed circular DNA (cccDNA), which serves as template for HBV RNA transcription, is responsible failure eradicating chronic during current antiviral therapy. cccDNA assembled with cellular histone proteins into chromatin, but little known about regulation chromatin by posttranslational modifications. In this study, we identified silent mating type information 2 homolog 3 (SIRT3) host...
The copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is regarded as a prime example of "click chemistry", but the asymmetric click internal alkynes still remains challenging. A new Rh-catalyzed N-alkynylindoles with azides was developed, providing atroposelective access to C-N axially chiral triazolyl indoles, type heterobiaryl, excellent yields and enantioselectivity. This approach efficient, mild, robust atom-economic, features very broad substrate scope easily available...
Abstract Objective The study's objective was to explore whether early time‐restricted eating (eTRE) and late (lTRE) have different impacts on intrahepatic fat metabolic health among patients with nonalcoholic fatty liver disease (NAFLD). Methods This is an 8‐week, randomized, parallel‐arm, open‐label trial. Forty eligible were randomly assigned eTRE (eating between 8:00 a.m. 4:00 p.m.) or lTRE 12:00 p.m. p.m.). primary outcome the change of measured by magnetic resonance image‐derived proton...
Uric acid (UA) is a complex phenotype influenced by both genetic and environmental factors as well their interactions. Current genome-wide association studies (GWASs) have identified variety of determinants UA in Europeans; however, such Asians, especially Chinese populations remain limited.A two-stage GWAS was performed to identify single nucleotide polymorphisms (SNPs) that were associated with serum uric population 12,281 participants (GWAS discovery stage included 1452 from the...
Background/Aim The hepatitis B virus (HBV) infection is accompanied by the induction of oxidative stress, especially mediated HBV X protein (HBx). Oxidative stress has been implicated in a series pathological states, such as DNA damage, cell survival and apoptosis. However, host factor which cells protect themselves under this poorly understood. Methodology/Principal Findings In study, we first confirmed that significantly induced stress. Moreover, viral HBx plays major role HBV....
Background and Purpose— The relationship between infarct dimensions neurological progression in patients with acute pontine infarctions remains unclear. This study aimed to investigate the morphometric predictive value of magnetic resonance imaging for early deterioration (END) infarction. Methods— We included all admitted our department having an ischemic stroke pons. ventrodorsal length multiplied by thickness was measured as parameters size. END defined incremental increase National...
Short-term exposure to air pollution has been associated with ischemic stroke (IS) hospitalizations, but the evidence of its effects on IS in low- and middle-income countries is limited inconsistent. We aimed quantitatively estimate association between hospitalizations for Chongqing, China. This time series study included 2,299 inpatients from three hospitals Chongqing January 2015 December 2016. Generalized linear regression models combined a distributed lag nonlinear model (DLNM) were used...
// Na-Na Tao 1, * , Hong-Zhong Zhou Hua Tang 2, Xue-Fei Cai 1 Wen-Lu Zhang Ji-Hua Ren Li 3 Xiang Chen Ke Wan-Yu Bo Liu Qiu-Xia Yang Sheng-Tao Cheng Li-Xia Huang Ai-Long 2 Juan Key Laboratory of Molecular Biology for Infectious Diseases (Ministry Education), Institute Viral Hepatitis, Department Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China Collaborative Innovation Center Diagnosis and Treatment Zhejiang Zhejiang, Epidemiology, School Public Health...
Accumulating evidence has linked environmental exposure, such as ambient air pollution and meteorological factors, to the development severity of cardiovascular diseases (CVDs), resulting in increased healthcare demand. Effective prediction demand for services, particularly those associated with peak events CVDs, can be useful optimizing allocation medical resources. However, few studies have attempted adopt machine learning approaches excellent predictive abilities forecast CVDs. This study...
Mounting evidence supports the role of neuroinflammation in radiation-induced brain injury (RIBI), a chronic disease characterized by delayed and progressive neurological impairment. Asparagine endopeptidase (AEP), also known as legumain (LGMN), participates multiple malignancies neurodegenerative diseases may potentially be involved RIBI. Here, we found AEP expression was substantially elevated cortex hippocampus wild-type (
Background/Aims: FOXO3a is an essential tumor suppressor that regulates the mechanisms of tumorigenesis and leukemogenesis. polymorphisms have not been reported previously associated with increased risk for childhood acute lymphoblastic leukemia (ALL). In this study, rs4946936 polymorphism located in 3'UTR was selected to evaluate its relationship a ALL Chinese children. Methods: Questionnaires, SNaPshot genotyping, real-time PCR, cell transfection dual luciferase reporter assays were used...
Progesterone plays an important role in mammary epithelial cell proliferation and differentiation. Evidence from experimental clinical studies indicates that progesterone is a risk factor for breast cancer under certain conditions through binding nuclear receptor (PR). These mechanisms, however, are not applicable to triple-negative (TNBC) due the lack of PR these cancers. In this study, we demonstrate membrane α (mPRα) expressed TNBC tissues expression level mPRα negatively associated with...
Eosinophilic gastrointestinal is an uncommon disorder affecting all tissues of the digestive tract. gastroenteritis presents with a complex clinical profile, lacks specificity, and prone to misdiagnosis in patients without evident allergens. In some instances, it mistaken for acute abdomen or tumor, potentially leading unnecessary surgical interventions. We present case 21-year-old female eosinophilic whose primary manifestations were abdominal pain ascites.
Abstract Recent studies have shown that fibrotic scar formation following cerebral ischemic injury has varying effects depending on the microenvironment. However, little is known about how fibrosis induced and regulated after injury. Sonic hedgehog signaling participates in heart, liver, lung, kidney. Whether Shh modulates stroke underlying mechanisms are unclear. In this study, we found Hedgehog expression was upregulated patients with acute a middle artery occlusion/reperfusion rat model....
Over the last few decades, epithelial-to-mesenchymal transition (EMT) has been identified as being involved in a number of aspects physiological processes and various pathological events, including embryonic development renal fibrosis. Transforming growth factor‑β receptor 2 (TGFβR2) is widely studied gene, which fulfils vital role TGFβ signaling pathway exerts crucial function progression EMT. Previous studies demonstrated that dysregulation microRNAs (miRNAs) considered to be associated...
Hepatitis B virus (HBV) infection is a common infectious disease, in which nuclear covalently closed circular DNA (cccDNA) plays key role viral persistence, reactivation after treatment withdrawal, and drug resistance. A recent genome-wide association study has identified that the ubiquitin conjugating enzyme E2 L3 (UBE2L3) gene associated with increased susceptibility to chronic HBV (CHB) adults. However, between UBE2L3 children CHB underlying mechanism remain unclear. In this study, we...