A5065424182- Head and Neck Cancer Studies
- Brain Metastases and Treatment
- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Salivary Gland Tumors Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Air Quality and Health Impacts
- Lung Cancer Research Studies
- Smoking Behavior and Cessation
- Head and Neck Surgical Oncology
- CAR-T cell therapy research
- Air Quality Monitoring and Forecasting
- Indoor Air Quality and Microbial Exposure
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 epidemiological studies
- Noise Effects and Management
- Virus-based gene therapy research
- Infection Control and Ventilation
- Diabetes Management and Research
- Surgical site infection prevention
- Lymphoma Diagnosis and Treatment
- Statistical Methods and Bayesian Inference
- Lung Cancer Diagnosis and Treatment
- Influenza Virus Research Studies
University of Cincinnati Medical Center
2016-2025
University of Cincinnati
2015-2024
Oncology Hematology Care
2019
Environmental Health
2018
Cincinnati Children's Hospital Medical Center
2018
University of Washington
2011-2014
Seattle University
2013
Pennsylvania State University
2012
The short-term and acute health effects of fine particulate matter less than 2.5 μm (PM2.5) have highlighted the need for exposure assessment models with high spatiotemporal resolution. Here, we utilize satellite, meteorologic, atmospheric, land-use data to train a random forest model capable accurately predicting daily PM2.5 concentrations at resolution 1 × km throughout an urban area encompassing seven counties. Unlike previous based on aerosol optical density (AOD), show that missingness...
Abstract Purpose: Patients with resected, local–regionally advanced, head and neck squamous cell carcinoma (HNSCC) have a one-year disease-free survival (DFS) rate of 65%–69% despite adjuvant (chemo)radiotherapy. Neoadjuvant PD-1 immune-checkpoint blockade (ICB) has demonstrated clinical activity, but biomarkers response effect on remain unclear. Methods: Eligible patients had resectable the oral cavity, larynx, hypopharynx, or oropharynx (p16-negative) stage T3-T4 and/or two more nodal...
Outdoor traffic-related airborne particles can infiltrate a building and adversely affect the indoor air quality. Limited information is available on effectiveness of high efficiency particulate (HEPA) filtration particles. Here, we investigated portable HEPA cleaners in reducing concentrations other aerosols, including black carbon (BC), PM2.5, ultraviolet absorbing matter (UVPM) (a marker tobacco smoke), fungal spores. This intervention study consisted placebo-controlled cross-over design,...
Importance Cytokine storm due to COVID-19 can cause high morbidity and mortality may be more common in patients with cancer treated immunotherapy (IO) immune system activation. Objective To determine the association of baseline immunosuppression and/or IO-based therapies severity cytokine cancer. Design, Setting, Participants This registry-based retrospective cohort study included 12 046 reported Cancer Consortium (CCC19) registry from March 2020 May 2022. The CCC19 is a centralized...
Traffic-related airborne particles are associated with asthma morbidity. The aim of this study was to assess the impact a high-efficiency particulate air (HEPA) filtration on concentrations traffic and resultant effect children asthma. Forty-three were enrolled in double-blind, placebo-controlled crossover design. A HEPA cleaner or placebo "dummy" placed participants' homes for four weeks, interrupted by one-month washout period, before crossing over other treatment arm weeks. Air sampling...
Summary Probabilistic models for infectious disease dynamics are useful understanding the mechanism underlying spread of infection. When likelihood function these is expensive to evaluate, traditional likelihood-based inference may be computationally intractable. Furthermore, lead poor parameter estimates and fitted model not capture important biological characteristics observed data. We propose a novel approach resolving issues that inspired by recent work in emulation calibration complex...
Evaluating fungal contamination indoors is complicated because of the many different sampling methods utilized.
Abstract Background There is a paucity of data evaluating the strategy suppressing broader-spectrum antibiotic susceptibilities on utilization. Cascade reporting (CR) antimicrobial susceptibility test results in which secondary (eg, broader-spectrum, costlier) agents may only be reported if an organism resistant to primary within particular drug class. Our objective was evaluate impact ceftriaxone-based cascade utilization cefepime and clinical outcomes patients with ceftriaxone-susceptible...
The efficacy of cetuximab is poor in metastatic head and neck squamous cell carcinoma (HNSCC). Cetuximab initiates natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity, with resultant recruitment immune cells suppression antitumor immunity. We hypothesized that adding an immune-checkpoint inhibitor (ICI) could overcome this lead to enhanced response.A phase II study durvalumab HNSCC was conducted. Eligible patients had measurable disease. Patients who received both ICI...
Background The 5‐year overall survival (OS) rate remains at 50% for patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC), thereby underscoring the need improved treatments. An antidiabetic agent, metformin, was found in retrospective studies to improve HNSCC. Therefore, authors conducted a phase 1 dose escalation study combining metformin chemoradiotherapy LAHNSCC. Methods Nondiabetic LAHNSCC were enrolled current receive escalating doses of CRT based on modified...
<h3>Importance</h3> Between 2015 and 2017, Ohio had the second highest number of opioid-related deaths. In July 2015, General Assembly approved a law allowing pharmacists to dispense naloxone without prescription in accordance with physician-approved protocol. This change allowed have more opportunity participate management patients who were addicted opioids. <h3>Objective</h3> To determine association between implementation an protocol dispensing rates. <h3>Design, Setting,...
Immunotherapy has emerged as a promising treatment modality for head and neck squamous cell carcinoma (HNSCC). Pembrolizumab, an anti-programmed death 1 antibody, is immunotherapy agent currently approved metastatic HNSCC curative intent clinical trials. Although responses to pembrolizumab are promising, many patients fail respond. However, it well known that T cytotoxicity chemotaxis critically important in the elimination of tumors. These functions depend on ion channel activity downstream Ca
Abstract Objective: To identify Surgical Site Infection (SSI) risk factors for abdominal hysterectomy patients and report the results of a performance improvement initiative. Design: Retrospective case-control. Setting: Parkland Hospital, an 882-bed academic, safety-net, tertiary referral center level 1 trauma serving diverse population primarily uninsured in North Texas. Participants: Patients over 18 who underwent were diagnosed with SSIs within 30 days surgery between 2019 2021. Methods:...
Objective Compare the burden of heavy metals in plasma from people with frontotemporal degeneration (FTD) and healthy controls. Methods A cross-sectional study 14 FTD cases 28 controls recruited University Cincinnati. Plasma samples were sent to Trace Element Analysis Core at Dartmouth College for assessment 24 or metalloids via inductively coupled mass spectrometry (ICP-MS). Unconditional logistic regression models performed adjustments age (centered median) sex. Results After adjusting...