Polybrominated diphenyl ethers (PBDEs) are widely used flame retardant compounds that persistent and bioaccumulative therefore have become ubiquitous environment contaminants. Animal studies suggest prenatal PBDE exposure may result in adverse neurodevelopmental effects.In a longitudinal cohort initiated after 11 September 2001, including 329 mothers who delivered one of three hospitals lower Manhattan, New York, we examined neurodevelopment when their children were 12-48 72 months age.We...

Air samples from a plant engaged in recycling electronics goods, factory assembling printed circuit boards, computer repair facility, offices equipped with computers, and outdoor air have been analyzed respect to their content of brominated hydrocarbon phosphate ester flame retardants. Polybrominated diphenyl ethers, polybrominated biphenyls, 1,2-bis(2,4,6-tribromophenoxy)ethane, tetrabromobisphenol A, organophosphate esters were all detected the indoor samples, highest concentrations being...

Background There is emerging evidence that background exposure to persistent organic pollutants (POPs) are important in the development of conditions predisposing diabetes as well type 2 itself. We recently reported low dose POPs predicted incident a nested case-control study. The current study examined if future adiposity, dyslipidemia, and insulin resistance among controls without Methodology/Principal Findings 90 were diabetes-free during 20 years follow-up. They stratified random sample,...

California children's exposures to polybrominated diphenyl ether flame retardants (PBDEs) are among the highest worldwide. PBDEs known endocrine disruptors and neurotoxicants in animals.Here we investigate relation of utero child PBDE exposure neurobehavioral development participants CHAMACOS (Center for Health Assessment Mothers Children Salinas), a birth cohort.We measured maternal prenatal serum samples examined association concentrations with attention, motor functioning, cognition at 5...

Passage of environmental chemicals across the placenta has important toxicological consequences, as well for choosing samples analysis and interpreting results. To obtain systematic data, we collected in 2000 maternal cord blood, tissue, placenta, milk connection with births Faroe Islands, where exposures to marine contaminants is increased. In 15 sample sets, measured a total 87 chemicals, almost all which were detected both fetal tissues. The serum lipid-based concentrations organohalogen...

Polybrominated diphenyl ethers (PBDEs) and 2,2',4,4',5,5'-hexabromobiphenyl (BB-153) are chemicals known as brominated flame retardants. We have assessed the exposure status of United States population to PBDEs BB-153 explored associations with demographic information, including participants' age, sex, race/ethnicity. A total 2,062 serum samples, from participants in National Health Nutrition Examination Survey (NHANES) 2003-2004 aged 12 years older, were analyzed for BB-153; stratified...

Low doses of some persistent organic pollutants (POPs) associate cross-sectionally with type 2 diabetes, whereas associations high POP exposures are inconsistent.We investigated whether several POPs prospectively predict diabetes within the Coronary Artery Risk Development in Young Adults (CARDIA) cohort.Participants this nested case-control study were free 1987-1988. By 2005-2006, 90 controls remained cases developed diabetes. Using serum collected 1987-1988, we measured 8 organochlorine...

Endocrine-disrupting chemicals (EDCs) may be involved in the etiology of autism spectrum disorders, but identifying relevant within mixtures EDCs is difficult.Our goal was to identify gestational EDC exposures associated with autistic behaviors.We measured concentrations 8 phthalate metabolites, bisphenol A, 25 polychlorinated biphenyls (PCBs), 6 organochlorine pesticides, brominated flame retardants, and 4 perfluoroalkyl substances blood or urine samples from 175 pregnant women HOME (Health...

Human exposure to polybrominated diphenyl ether (PBDE) flame retardants has increased exponentially over the last three decades. Animal and human studies suggest that PBDEs may disrupt thyroid function. Although hormone (TH) of maternal origin plays an essential role in normal fetal brain development, there is a paucity data regarding associations between TH levels during pregnancy.Our goal was determine whether PBDE serum concentrations are associated with pregnant women.We measured...

Exposure to polybrominated diphenyl ether (PBDE) flame retardants is widespread, with 97% of Americans having detectable levels. Although PBDEs have been associated reproductive and hormonal effects in animals, no human studies examined their association fertility.This study was designed determine whether maternal concentrations serum collected during pregnancy are time menstrual cycle characteristics.Pregnant women (n = 223) living a low-income, predominantly Mexican-immigrant community...

Polybrominated diphenyl ethers (PBDEs) are persistent, bioaccumulative, and endocrine-disrupting chemicals.

Polybrominated diphenyl ethers (PBDEs) are persistent chemicals that have been widely used as flame retardants in furniture, carpet padding, car seats, and other consumer products during the past three decades.We examined whether utero exposure to PBDEs is associated with child cognitive function behavior a U.S. study sample.In prospective birth cohort, we measured maternal serum concentrations of BDE-47 PBDE congeners 309 women at 16 weeks gestation 2003-2006 followed their children...

Background:Polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) are neurodevelopmental toxicants, but few studies have examined associations with autism spectrum disorder (ASD).Objectives:We aimed to determine whether prenatal exposure PCBs OCPs influences offspring risk of ASD intellectual disability without (ID).Methods:We conducted a population-based case–control study among Southern California births, including children (n = 545) meeting Diagnostic Statistical Manual...

Polybrominated diphenyl ethers (PBDEs) are used as additives in polymers and textiles to prohibit the development of fires. Because production use PBDEs, their lipophilic characteristics, persistence, these compounds have become ubiquitous environmental contaminants. The aim present study was determine potential exposures PBDEs clerks working full-time at computer screens personnel an electronics-dismantling plant, with hospital cleaners a control group. Five PBDE...

Six polybrominated diphenyl ethers (PBDEs), one hexabromobiphenyl [polybrominated biphenyl (PBB)], and hexachlorobiphenyl [polychlorinated (PCB)] were measured in 40 human serum pools collected the southeastern United States during 1985 through 2002 Seattle, Washington, for 1999 2002. The concentrations of most PBDEs, which are commercially used as flame retardants common household commercial applications, had significant positive correlations with time sample collection, showing that these...

The aim of the present study was to model apparent serum half-lives polybrominated diphenyl ethers (PBDEs) with 7-10 bromine substituents. Workers occupational exposure PBDEs have elevated levels PBDEs, but these substances are also found in general population and ubiquitous environmental contaminants. calculations were based on assessments rubber workers (manufactured flame-retarded compound) electronics dismantlers who donated blood during a period no work-related exposures referents...

A semiautomated extraction and cleanup method has been developed for the measurement of eight polybrominated diphenyl ethers (PBDEs), 2,2',4,4',5,5'-hexabromobiphenyl (BB-153) 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153). The employs automated addition internal standards ((13)C-labeled), formic acid (denaturation agent), dilution with water prior to overnight using a modular solid-phase (SPE) system. Removal coextracted biogenic materials was performed on two-layered 3-mL disposable cartridge...

We examined the influence of widely varied consumption fatty fish from Baltic Sea and age on plasma concentrations polychlorinated biphenyls (PCBs), polychlorobiphenylols (OH-PCBs), 2, 2-bis(4-chlorophenyl)-1,1,1-trichloroethane (4,4'-DDT), 2-bis(4-chlorophenyl)-1,1-dichloroethane (4,4'-DDE), 2,2',4, 4'-tetrabromodiphenyl ether (BDE-47), hexachlorobenzene (HCB), pentachlorophenol (PCP) in Latvian Swedish men. Both were significantly correlated with [sigman]PCB, [sigman]OH-PCB, 4,4'-DDE,...

Polybrominated diphenyl ethers (PBDEs) have been measured in the home environment and humans, but studies linking environmental levels to body burdens are limited. This study examines relationship between PBDE concentrations house dust serum from adults residing these homes. We 50 homes of male−female couples 12 Detection rates, dust-serum, within-matrix correlations varied by congener. There was a strong correlation (r = 0.65−0.89, p < 0.05) several predominant congeners (BDE 47, 99, 100)....