A5009840656- Pancreatic and Hepatic Oncology Research
- Hepatitis B Virus Studies
- Neuroendocrine Tumor Research Advances
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Advanced biosensing and bioanalysis techniques
- Inflammatory Biomarkers in Disease Prognosis
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Neuroblastoma Research and Treatments
- Pancreatitis Pathology and Treatment
- Biosensors and Analytical Detection
- Nanoplatforms for cancer theranostics
- X-ray Diffraction in Crystallography
- MicroRNA in disease regulation
- Lung Cancer Research Studies
- Immune Response and Inflammation
- Glycosylation and Glycoproteins Research
- Crystallography and molecular interactions
- Crystallization and Solubility Studies
- Liver physiology and pathology
- Renal cell carcinoma treatment
- RNA Interference and Gene Delivery
Second Military Medical University
2021-2025
Changhai Hospital
2021-2025
Dalian University
2025
Dalian University of Technology
2025
Southeast University
2024
State Key Laboratory of Digital Medical Engineering
2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2007-2024
University of South China
2024
Affiliated Hospital of Southwest Medical University
2021-2023
AIM:To explore the possible mechanism of intrauterine infection hepatitis B virus (HBV). METHODS:HBV DNA was detected in vaginal secretion and amniotic fluid from 59 HBsAg-positive mothers venous blood their newborns by PCR.HBsAg HBcAg placenta were determined ABC immunohistochemistry. RESULTS:The rate HBV 40.1% (24/59).HBV 47.5% samples 52.5% respectively.HBsAg placentas HBsAgpositive mothers.The concentration two antigens decreased mother's side to fetus's side, following order: maternal...
Sirtuin 2 (SIRT2) is a nicotinamide adenine dinucleotide (NAD +)-dependent class III histone deacetylase. We have reported that HBx (hepatitis B virus X protein)-elevated SIRT2 promotes HBV replication and hepatocarcinogenesis. However, the potential anti-HBV effect of AGK2, selective inhibitor SIRT2, has not been reported. Here, role AGK2 on was examined in HepAD38 HepG2-NTCP cell lines. The genome stably integrated line which expresses under control tetracycline. cells expressing sodium...
Background Circulating tumor cells (CTCs) have been considered diagnostic and prognostic biomarkers for urothelial cancer. However, the role of CTCs in bladder cancer (BC) remains controversial. Here, we conducted a meta-analysis to evaluate significance patients with BC. Methods All studies relevant this topic were searched PubMed, Embase, Web Science databases. The hazard ratio (HR) 95% confidence interval (95% CI) set as effect measures. outcomes overall survival (OS), cancer-free (CSS),...
Hepatitis B virus (HBV) infection is a common infectious disease, in which nuclear covalently closed circular DNA (cccDNA) plays key role viral persistence, reactivation after treatment withdrawal, and drug resistance. A recent genome-wide association study has identified that the ubiquitin conjugating enzyme E2 L3 (UBE2L3) gene associated with increased susceptibility to chronic HBV (CHB) adults. However, between UBE2L3 children CHB underlying mechanism remain unclear. In this study, we...
Abstract Background Ropivacaine, a local anesthetic, exhibits anti-tumor effects in various cancer types. However, its specific functions and the molecular mechanisms involved breast cell stemness remain elusive. Methods The of ropivacaine on were investigated by vitro vivo assays (i.e., FACs, MTT assay, mammosphere formation transwell assays, western blot, xenograft model). RNA-seq, bioinformatics analysis, Western Luciferase reporter CHIP assay used to explore mechanistic roles...
Hepatitis B virus (HBV) is a major public health threat and anti-HBV drugs are limited to nucleos(t)ide analogs (NAs) pegylated interferon alpha (Peg-IFNα). Toward identifying an effective compound for HBV treatment important suppress eradicate HBV. In this study, we explored the anti-viral effect of Sirtuin 6 (SIRT6) inhibitor, OSS_128167, in transcription replication. Firstly, found that OSS_128167 could decrease level core deoxyribonucleic acid (DNA) 3.5-Kb ribonucleic (RNA) vitro....
<h2>Abstract</h2> Background: Hepatitis B surface antigen (HBsAg) is one of the important clinical indexes for hepatitis virus (HBV) infection diagnosis and sustained seroconversion HBsAg an indicator functional cure. However, level could not be reduced by interferons nucleoside analogs effectively. Therefore, identification a new drug targeting urgently needed. Methods: In this study, 6-AN was screened out from 1500 compounds due to its low cytotoxicity high antiviral activity. The effect...
Abstract Adjuvant therapy for pancreatic neuroendocrine tumors (PanNETs) after radical resection lacks evidence‐based data and remains controversial. This study aimed to validate whether long‐acting octreotide is a potential candidate adjuvant in patients with G2 PanNETs at high recurrence risk by clustering real‐world data. A retrospective review of nonmetastatic grade 2 who underwent six research centers between 2008 2020 was conducted. Propensity score matching inverse probability...
Summary Interleukin‐21 ( IL ‐21) participates in tissue damage various immune‐mediated diseases. Its role the pathogenesis of chronic active hepatitis B CAHB ) has not been clarified. The frequency circulating ‐21 + T cells and levels serum intrahepatic have characterized 70 patients, 32 inactive carrier IC ), 18 C CHC 20 healthy controls HC ). Their potential association with liver injury was analysed. percentages CD 3 8 − patients were significantly higher than that , P < 0.001)...
Hepatocellular carcinoma (HCC) is rising steadily in incidence, and more effective methods are needed for early cancer detection image-guided surgery.We used a structural model to optimize the peptide sequence. Specific binding was validated vitro with knockdown, competition, co-localization assays. Multi-modal imaging performed validate specific vivo orthotopically-implanted human xenograft tumors.Binding properties of WKGWSYLWTQQA were characterized by an apparent dissociation constant kd...