A5100772102- Telomeres, Telomerase, and Senescence
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Carcinogens and Genotoxicity Assessment
- Air Quality and Health Impacts
- RNA modifications and cancer
- Health, Environment, Cognitive Aging
- Advanced biosensing and bioanalysis techniques
- Molecular Biology Techniques and Applications
- Pesticide Exposure and Toxicity
- COVID-19 epidemiological studies
- Urinary Bladder and Prostate Research
- interferon and immune responses
- Metabolism and Genetic Disorders
- Meat and Animal Product Quality
- Postharvest Quality and Shelf Life Management
- Ovarian function and disorders
- Genetics, Aging, and Longevity in Model Organisms
- DNA Repair Mechanisms
- Food Quality and Safety Studies
- RNA and protein synthesis mechanisms
- COVID-19 and healthcare impacts
- Monoclonal and Polyclonal Antibodies Research
- Prostate Cancer Diagnosis and Treatment
- Plant Physiology and Cultivation Studies
Zhengzhou University
2016-2025
Sichuan University
2008-2025
Third Affiliated Hospital of Zhengzhou University
2007-2025
Hunan University
2006-2025
West China Hospital of Sichuan University
2014-2025
Henan Provincial Chest Hospital
2025
Chengdu University
2018-2024
Tianjin Hospital
2022-2024
Capital Medical University
2011-2024
Jinan University
2024
<h3>Importance</h3> Health care workers (HCWs) have high infection risk owing to treating patients with coronavirus disease 2019 (COVID-19). However, research on their and clinical characteristics is limited. <h3>Objectives</h3> To explore of HCWs COVID-19 discuss possible prevention measures. <h3>Design, Setting, Participants</h3> This single-center case series included 9684 in Tongji Hospital, Wuhan, China. Data were collected from January 1 February 9, 2020. <h3>Exposures</h3> Confirmed...
Nontraumatic osteonecrosis of the femoral head (NONFH) is a debilitating disease that represents significant financial burden for both individuals and healthcare systems. Despite its significance, however, prevalence in Chinese general population remains unknown. This study aimed to investigate NONFH associated risk factors population.A nationally representative survey 30,030 respondents was undertaken from June 2012 August 2013. All participants underwent questionnaire investigation,...
Leukemias are a group of life-threatening malignant disorders the blood and bone marrow. The incidence leukemia varies by pathological types among different populations.We retrieved data for sex, age, location, calendar year, type from Global Burden Disease online database. estimated average percentage change (EAPC) was used to quantify trends age-standardized rate (ASIR) 1990 2017.Globally, while number newly diagnosed cases increased 354.5 thousand in 518.5 2017, ASIR decreased 0.43% per...
The Sino-MONICA project is a 7-year study monitoring trends and determinants of cardiovascular disease (CVD) in geographically defined populations different parts China.The community-based prospective surveillance that uses the methodology criteria World Health Organization's Monitoring Trends Determinants Cardiovascular Disease (WHO MONICA) project, with slight modifications for local use. After pilot 2 years (1985 through 1986), data collection started formally on January 1, 1987, ended...
Halobenzoquinones (HBQs), a new class of disinfection byproducts (DBPs), occur widely in treated drinking water and recreational water. The main concern regarding human exposure to DBPs stems from epidemiological studies that have consistently linked the consumption chlorinated with an increased risk developing bladder cancer. U.S. Environmental Protection Agency Health Canada set regulations on amount minimize risk. However, these regulated do not account for cancer because they different...
Ferritin binds specifically and saturably to a variety of cell types, recently several ferritin receptors have been cloned. TIM-2 is specific receptor for H (HFt) in the mouse. member T immunoglobulin mucin domain containing (TIM) protein family plays an important role immunity. The expression outside immune system indicates that this may broader roles. We tested whether binding can serve as iron delivery mechanism. was transfected into normal (TCMK-1) mouse kidney cells, where it...
microRNAs (miRNAs) have been a class of promising disease diagnostic biomarkers and therapeutic targets for their important biological functions. However, because the high homology, interference from precursors (pri-miRNA, pre-miRNA), as well limitations in current assay technologies, it poses demand challenge specific, efficient, economic miRNA method. Here, we propose new detection method based on label-free probe small organic dye with sequence dependence, realizing sequence-specific...
Abstract Background Intrabodies are defined as antibody molecules which ectopically expressed inside the cell. Such intrabodies can be used to visualize or inhibit targeted antigen in living cells. However, most fragments cannot because they do not fold under reducing conditions of cell cytosol and nucleus. Results We describe construction validation a large synthetic human single chain fragment library based on unique framework optimized for cytoplasmic expression. Focusing by mimicking...
Background and aim:The prevalence of the hepatitis B virus (HBV) is higher in adults than children.We determined seroepidemiology HBV infection an adult population JiLin, China, to guide effective preventive measures.Methods: A cross-sectional serosurvey was conducted throughout China.A total 3833 people selected demographic behavioral information gathered.Serum samples were tested for markers liver enzymes. Results:The surface antigen (HBsAg), antibody (anti-HBs), e (HBeAg), HBeAg...
Abstract Phenylketonuria (PKU) is an inherited autosomal recessive disorder of phenylalanine metabolism, mainly caused by a deficiency hydroxylase ( PAH ). The incidence various mutations differs among race and ethnicity. Here we report spectrum complied from 796 PKU patients mainland China. all 13 exons adjacent intronic regions the gene were determined next-generation sequencing. We identified 194 different mutations, which 41 are not reported before. Several reoccurred with high frequency...
Organophosphorus insecticide diazinon (DZN) is diffusely used in agriculture, home gardening, and crop peats. Much work so far has focused on the link between DZN exposure occurrence of neurological diseases, while little known reproductive toxicological assessment exposure. This research aimed to investigate underlying mechanisms toxic hazards for cultured porcine ovarian granulosa cells. We analyzed oxidative stress, energy metabolism, DNA damage, apoptosis, autophagy by using...
Background: miR-146a polymorphisms have been involved in susceptibility to multiple diseases. The aim of the present study was analyze potential association between two functional (rs2910164 and rs57095329) sclerosis (MS) Han Chinese population. Methods: A cohort 525 patients 568 healthy controls were genotyped detect by SNaPshot. Results: No significant differences detected distribution (P > 0.05). However, stratification gender showed a statistically difference frequency genotype...
Abstract Among several leading cardiovascular disorders, ischemia–reperfusion (I/R) injury causes severe manifestations including acute heart failure and systemic dysfunction. Recently, there has been increasing evidence suggesting that alterations in mitochondrial morphology dysfunction also play an important role the prognosis of cardiac disorders. Long non-coding RNAs (lncRNAs) form major regulatory networks altering gene transcription translation. While lncRNAs extensively studied cancer...