A5101550261- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Genetic and phenotypic traits in livestock
- Genomics and Rare Diseases
- Genetic Mapping and Diversity in Plants and Animals
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Obesity, Physical Activity, Diet
- Bipolar Disorder and Treatment
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bioinformatics and Genomic Networks
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Disease and Adiposity
- Cognitive Abilities and Testing
- Lipoproteins and Cardiovascular Health
- Alcohol Consumption and Health Effects
- Nutrition, Genetics, and Disease
- Substance Abuse Treatment and Outcomes
- Reproductive System and Pregnancy
- Prenatal Screening and Diagnostics
- Genetics and Neurodevelopmental Disorders
- Cancer-related molecular mechanisms research
- BRCA gene mutations in cancer
National Health Research Institutes
2020-2025
National Yang Ming Chiao Tung University
2005-2025
National Cheng Kung University
1997-2025
Neuropsychiatric Research Institute
2021-2025
University of Oxford
2018-2024
Medical Research Council
2021-2024
Shanxi Medical University
2024
Taipei City Hospital
2018-2023
Taipei Municipal YangMing Hospital
2023
University of Bristol
2022
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect genetic effects). Family-based GWAS designs can control for demographic indirect effects, but large-scale family datasets have been lacking. We combined data 178,086 siblings 19 cohorts to generate population (between-family) within-sibship (within-family) estimates 25...
Adherence to a combination of healthy lifestyle factors has been related considerable reduction cardiovascular risk in white populations; however, little is known whether such associations persist nonwhite populations like the Asian population.
Abstract Background Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic and environmental risk factors that disproportionately afflicts communities of color. Leveraging existing large-scale genome-wide association studies (GWAS), polygenic scores (PRS) have shown promise to complement established clinical intervention paradigms, improve early diagnosis prevention T2D. However, date, T2D PRS been most widely developed validated in individuals European descent. Comprehensive...
Tobacco smoking is estimated to account for more than 1 million annual deaths in China, and the epidemic continues increase men. Large nationwide prospective studies linked different health records can help periodically assess disease burden attributed smoking. We aimed examine associations of with incidence mortality from an extensive range diseases China.We analysed data China Kadoorie Biobank, which recruited 512 726 adults aged 30-79 years, whom 210 201 were men 302 525 women....
Abstract Alcohol consumption accounts for ~3 million annual deaths worldwide, but uncertainty persists about its relationships with many diseases. We investigated the associations of alcohol 207 diseases in 12-year China Kadoorie Biobank >512,000 adults (41% men), including 168,050 genotyped ALDH2 - rs671 and ADH1B rs1229984 , >1.1 ICD-10 coded hospitalized events. At baseline, 33% men drank regularly. Among men, intake was positively associated 61 diseases, 33 not defined by World...
The Taiwan Biobank (TWB) is an ongoing prospective study of >150,000 individuals aged 20-70 in Taiwan. A comprehensive list phenotypes was collected for each consented participant at recruitment and follow-up visits through structured interviews physical measurements. Biomarkers genetic data were generated from blood urine samples. We present here overview TWB's quality, population structure, familial relationship, which consists predominantly Han Chinese ancestry, highlight its important...
Abstract Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism 1–7 . This detailed knowledge genetic determinants systemic has been pivotal for uncovering how pathways influence biological mechanisms and complex diseases 8–11 Here we present a genome-wide study 233 circulating metabolic traits quantified by nuclear magnetic resonance spectroscopy in up 136,016 participants from 33 cohorts. We identify...
The China Kadoorie Biobank (CKB) is a population-based prospective cohort of >512,000 adults recruited from 2004 to 2008 10 geographically diverse regions across China. Detailed data questionnaires and physical measurements were collected at baseline, with additional three resurveys involving ∼5% surviving participants. Analyses genome-wide genotyping, for >100,000 participants using custom-designed Axiom arrays, reveal extensive relatedness, recent consanguinity, signatures reflecting...
Abstract Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples European ancestry. Here we report a multi-ancestry GWAS MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to previously reported data. This analysis used range measures define included African (36% effective sample size), East Asian (26%) South (6%) ancestry Hispanic/Latin American participants (32%). The identified 53 significantly associated novel loci. For...
BackgroundThe age-specific association between blood pressure and vascular disease has been studied mostly in high-income countries, before the widespread use of brain imaging for diagnosis main stroke types (ischaemic intracerebral haemorrhage). We aimed to investigate this relationship among adults China.Methods512 891 (59% women) aged 30–79 years were recruited into a prospective study from ten areas China June 25, 2004, July 15, 2008. Participants attended assessment centres where they...
Abstract Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform multi-stage genome-wide association study (max N = 289,038) principally in East Asians meta-analysis Europeans. We report 19 new ancestry-specific variants, conforming to common variant model. At 10 unique loci, distinct non-rare variants colocalize within the same linkage disequilibrium block despite significantly discordant effects...
Abstract Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants blood lipids, a major cardiovascular risk factor, shared across populations. Genetic correlations for lipids between European-ancestry and Asian cohorts not significantly different from 1. A score LDL-cholesterol-associated loci has consistent effects serum levels in UK, Uganda Greece ( r = 0.23–0.28, p < 1.9 × 10 −14 ). Overall, there is evidence...
Abstract Estimates from genome-wide association studies (GWAS) represent a combination of the effect inherited genetic variation (direct effects), demography (population stratification, assortative mating) and nurture relatives (indirect effects). GWAS using family-based designs can control for indirect effects, but large-scale family datasets have been lacking. We combined data on 159,701 siblings 17 cohorts to generate population (between-family) within-sibship (within-family) estimates...
ABSTRACT Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As existing genome-wide association studies (GWAS) were predominantly conducted in individuals of European descent, the limited transferability PRS reduces its clinical value non-European populations and may exacerbate healthcare disparities. Recent efforts to level ancestry imbalance genomic research expanded scale GWAS, although most them remain under-powered. Here we present a novel construction...