Alexander Kurilshikov
A5041087253- Gut microbiota and health
- Diet and metabolism studies
- Nutritional Studies and Diet
- Epigenetics and DNA Methylation
- Bacteriophages and microbial interactions
- Clostridium difficile and Clostridium perfringens research
- Nutrition, Genetics, and Disease
- Gastrointestinal motility and disorders
- Viral gastroenteritis research and epidemiology
- Food Security and Health in Diverse Populations
- Helicobacter pylori-related gastroenterology studies
- Nutrition, Health and Food Behavior
- Metabolomics and Mass Spectrometry Studies
- Respiratory viral infections research
- Tryptophan and brain disorders
- Inflammatory Bowel Disease
- Plant Virus Research Studies
- Cancer Genomics and Diagnostics
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Infant Nutrition and Health
- Genomics and Phylogenetic Studies
- Vector-borne infectious diseases
- Liver Disease Diagnosis and Treatment
- Viral Infections and Vectors
University Medical Center Groningen
2016-2025
University of Groningen
2016-2025
Institute of Chemical Biology and Fundamental Medicine
2012-2021
Siberian Branch of the Russian Academy of Sciences
2012-2021
ORCID
2020
Nutricia Research (Netherlands)
2020
Danone (France)
2020
Danone Nutricia Research (Netherlands)
2020
The London College
2020
King's College London
2020
“Normal” for the gut microbiota For benefit of future clinical studies, it is critical to establish what constitutes a “normal” microbiome, if exists at all. Through fecal samples and questionnaires, Falony et al. Zhernakova targeted general populations in Belgium Netherlands, respectively. Gut composition correlated with range factors including diet, use medication, red blood cell counts, chromogranin A, stool consistency. The data give some hints possible biomarkers normal communities....
“Normal” for the gut microbiota For benefit of future clinical studies, it is critical to establish what constitutes a “normal” microbiome, if exists at all. Through fecal samples and questionnaires, Falony et al. Zhernakova targeted general populations in Belgium Netherlands, respectively. Gut composition correlated with range factors including diet, use medication, red blood cell counts, chromogranin A, stool consistency. The data give some hints possible biomarkers normal communities....
The human gut microbiota has now been associated with drug responses and efficacy, while chemical compounds present in these drugs can also impact the bacteria. However, drug-microbe interactions are still understudied clinical context, where polypharmacy comorbidities co-occur. Here, we report relations between commonly used microbiome. We performed metagenomics sequencing of faecal samples from a population cohort two gastrointestinal disease cohorts. Differences users non-users were...
Differences in gut microbiota composition and function were observed between patients with inflammatory bowel disease or irritable syndrome.
Abstract Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, has been suggested be triggered by endotoxins produced the gastrointestinal microbiome. Here we investigate relationship between joint microbiome composition, knee Rotterdam Study; large population based cohort study. We show that abundance of Streptococcus species associated with increased pain, which validate absolute quantification species. In addition, replicate these...
Abstract Gut microbiota has been implicated in major diseases affecting the human population and also linked to triglycerides high-density lipoprotein levels circulation. Recent development metabolomics allows classifying particles into more details. Here, we examine impact of gut on circulating metabolites measured by Nuclear Magnetic Resonance technology 2309 individuals from Rotterdam Study LifeLines-DEEP cohort. We assess relationship between linear regression analysis while adjusting...
<h3>Importance</h3> Previous studies have indicated that gut microbiome may be associated with development of type 2 diabetes. However, these are limited by small sample size and insufficient for confounding. Furthermore, which specific taxa play a role in the diabetes remains unclear. <h3>Objective</h3> To examine associations composition insulin resistance large population-based setting controlling various sociodemographic lifestyle factors. <h3>Design, Setting, Participants</h3> This...
The levels of the thousands metabolites in human plasma metabolome are strongly influenced by an individual's genetics and composition their diet gut microbiome. Here, assessing 1,183 1,368 extensively phenotyped individuals from Lifelines DEEP Genome Netherlands cohorts, we quantified proportion inter-individual variation explained different factors, characterizing 610, 85 38 as dominantly associated with diet, microbiome genetics, respectively. Moreover, a quality score derived metabolite...
Abstract Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS independent cohorts. conducted genome-wide association study 53,400 433,201 controls replicated significant associations in 23andMe panel (205,252 1,384,055 controls). Our confirmed six genetic loci IBS. Implicated...
Alterations in the microbiota composition of gastro-intestinal tract are suspected to be involved etiopathogenesis two closely related systemic inflammatory autoimmune diseases: primary Sjögren's syndrome (pSS) and lupus erythematosus (SLE). Our objective was assess whether alterations gut oral compositions specific for pSS SLE.16S ribosomal RNA gene sequencing performed on fecal samples from 39 patients, 30 SLE patients 965 individuals general population, as well buccal swab washing same...