Karmel W. Choi
A5032674001- Resilience and Mental Health
- Genetic Associations and Epidemiology
- Health, Environment, Cognitive Aging
- Child Abuse and Trauma
- Posttraumatic Stress Disorder Research
- Health disparities and outcomes
- Birth, Development, and Health
- Migration, Health and Trauma
- Cognitive Abilities and Testing
- Child and Adolescent Psychosocial and Emotional Development
- Maternal Mental Health During Pregnancy and Postpartum
- Suicide and Self-Harm Studies
- Homelessness and Social Issues
- Cardiovascular Health and Risk Factors
- COVID-19 and Mental Health
- Adolescent Sexual and Reproductive Health
- Mental Health Research Topics
- Chronic Disease Management Strategies
- Obesity, Physical Activity, Diet
- Cardiac Health and Mental Health
- Nutrition, Genetics, and Disease
- Mental Health Treatment and Access
- Prenatal Substance Exposure Effects
- Stress Responses and Cortisol
- Substance Abuse Treatment and Outcomes
Massachusetts General Hospital
2017-2025
Harvard University
2017-2024
Stanley Center for Psychiatric Research
2018-2024
Broad Institute
2018-2024
Mass General Brigham
2024
The University of Queensland
2023
Boston University
2022-2023
Biogen (United States)
2020
NeuroDevelopment Center
2020
McLean Hospital
2020
For many years, psychiatrists have tried to understand factors involved in response medications or psychotherapies, order personalize their treatment choices. There is now a broad and growing interest the idea that we can develop models decisions using new statistical approaches from field of machine learning applying them larger volumes data. In this pursuit, there has been paradigm shift away experimental studies confirm refute specific hypotheses towards focus on overall explanatory power...
Pregnant and postpartum women face unique challenges during the COVID-19 pandemic that may put them at elevated risk of mental health problems. However, few large-scale no cross-national studies have been conducted to date investigate modifiable pandemic-related behavioral or cognitive factors influence in this vulnerable group. This international study sought identify measure associations between information seeking, worries, prevention behaviors on perinatal pandemic. An anonymous, online,...
Efforts to prevent depression, the leading cause of disability worldwide, have focused on a limited number candidate factors. Using phenotypic and genomic data from over 100,000 UK Biobank participants, authors sought systematically screen validate wide range potential modifiable factors for depression.
Abstract Background Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic and environmental risk factors that disproportionately afflicts communities of color. Leveraging existing large-scale genome-wide association studies (GWAS), polygenic scores (PRS) have shown promise to complement established clinical intervention paradigms, improve early diagnosis prevention T2D. However, date, T2D PRS been most widely developed validated in individuals European descent. Comprehensive...
The molecular pathology of stress-related disorders remains elusive. Our brain multiregion, multiomic study posttraumatic stress disorder (PTSD) and major depressive (MDD) included the central nucleus amygdala, hippocampal dentate gyrus, medial prefrontal cortex (mPFC). Genes exons within mPFC carried most disease signals replicated across two independent cohorts. Pathways pointed to immune function, neuronal synaptic regulation, hormones. Multiomic factor gene network analyses provided...
Abstract Mothers who have experienced childhood maltreatment are more likely to children also exposed maltreatment, a phenomenon known as intergenerational transmission. Factors in the perinatal period may contribute uniquely this transmission, but timing effects not been ascertained. Using structural equation modeling with 1,016 mothers and their 2,032 Environmental Risk Longitudinal Twin Study, we tested mediating role of postpartum depression between maternal cascade negative child...
Abstract Background Sedentary behaviour is potentially a modifiable risk factor for depression and anxiety disorders, but findings have been inconsistent. To assess the associations of sedentary with symptoms estimate impact replacing daily time spent in behaviours sleep, light, or moderate to vigorous physical activity, using compositional data analysis methods. Methods We conducted prospective cohort study 60,235 UK Biobank participants (mean age: 56; 56% female). Exposure was baseline...
Abstract Background The causal effects of gut microbiome and the development posttraumatic stress disorder (PTSD) are still unknown. This study aimed to clarify their potential association using mendelian randomization (MR). Methods summary-level statistics for were retrieved from a genome-wide (GWAS) MiBioGen consortium. As PTSD, Freeze 2 datasets originated Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group (PGC-PTSD), replicated obtained FinnGen Single nucleotide...
Prior studies have incompletely assessed whether the development of cardiometabolic risk factors (CVDRF) (hypertension, hyperlipidemia, and diabetes mellitus) mediates association between anxiety depression (anxiety/depression) cardiovascular disease (CVD).
High rates of depression and posttraumatic stress disorder (PTSD) contribute to sexual risk, particularly in men who have sex with (MSM) experienced childhood abuse. The comorbidity between PTSD mechanisms by which they risk MSM remain unclear. This study sought demonstrate the feasibility utility a network approach (a) characterize symptom interconnections MSM, (b) identify specific symptoms related behavior, (c) compare networks across groups at different levels risk.