Enrique Castelao
A5028256346- Genetic Associations and Epidemiology
- Child and Adolescent Psychosocial and Emotional Development
- Bipolar Disorder and Treatment
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Genetics and Neurodevelopmental Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Migration, Health and Trauma
- Child Abuse and Trauma
- Posttraumatic Stress Disorder Research
- Adolescent and Pediatric Healthcare
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Mental Health Research Topics
- Cardiac Health and Mental Health
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Suicide and Self-Harm Studies
- Schizophrenia research and treatment
- Cognitive Abilities and Testing
- Hormonal Regulation and Hypertension
- Health, Environment, Cognitive Aging
- Family Support in Illness
- Functional Brain Connectivity Studies
- Migraine and Headache Studies
- Sleep and Wakefulness Research
University of Lausanne
2016-2025
University of Utah
2023
Virginia Commonwealth University
2023
Huntsman (United States)
2023
University Hospital of Lausanne
2011-2020
Aarhus University
2019
National Institute of Mental Health
2018
Heidelberg University
2018
University Hospital Heidelberg
2018
Central Institute of Mental Health
2018
Abstract Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either or contributions DNAm, few assessed their integrated effects. Here we examine relative prenatal genotype on in neonatal blood at variably methylated regions (VMRs) 4 independent cohorts (overall n = 2365). We use Akaike’s information criterion test which best explain...
Abstract Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as reference, we estimate polygenic risk scores for depression (depression-PRS) in discovery ( N = 10,674) replication 11,214) imaging sample from UK Biobank. We report 77 traits that are significantly associated with depression-PRS, both analyses. Mendelian...
To assess the association between sleep structure and cognitive impairment in general population.Data stemmed from 580 participants aged >65 years of population-based CoLaus/PsyCoLaus study (Lausanne, Switzerland) who underwent complete evaluation (HypnoLaus). Evaluations included demographic characteristics, personal treatment history, complaints habits (using validated questionnaires), a polysomnography at home. Cognitive function was evaluated using comprehensive neuropsychological test...
Antidepressants are a first-line treatment for depression. However, only third of individuals experience remission after the first treatment. Common genetic variation, in part, likely regulates antidepressant response, yet success previous genome-wide association studies has been limited by sample size. This study performs largest analysis prospectively assessed response major depressive disorder to gain insight into underlying biology and enable out-of-sample prediction.
Abstract: Previous research has unveiled an intriguing positive association between the AB blood group and mental disorders in general. In this study, we compared ABO groups with five major of to attain a higher level specificity. The analyses were conducted using data from CoLaus|PsyCoLaus study (N=5111). They revealed that exhibited both neurodevelopmental (RR 2.29, CI 1.38– 3.82) substance use 2.25, 3.65) after adjusting for sex childhood adversities. These associations could be...
Vandeleur C, Rothen S, Gholam‐Rezaee M, Castelao E, Vidal Favre Ferrero F, Halfon O, Fumeaux P, Merikangas KR, Aubry J‐M, Burstein Preisig M. Mental disorders in offspring of parents with bipolar and major depressive disorders. Bipolar Disord 2012: 14: 641–653. © 2012 The Authors. Journal compilation John Wiley & Sons A/S. Objectives: There is limited information on the specificity associations between parental disorder (BPD) (MDD) risk psychopathology offspring. chief aim present study...
Abstract Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, initial studies inter-individual variance in have implicated genetic factors. However, whether variables share risk factors remains unclear. The aims the present twin study were to: (i) assess heritability HCC; (ii) estimate phenotypic correlation HPA activity perceived...
Abstract The major anxiety disorders (ANX; including generalized disorder, panic and phobias ) are highly prevalent, often onset early, persist throughout life, cause substantial global disability. Although distinct in their clinical presentations, they likely represent differential expressions of a dysregulated threat-response system. Here we present genome-wide association meta-analysis comprising 122,341 European ancestry ANX cases 729,881 controls. We identified 58 independent...