A5000891136- Child and Adolescent Psychosocial and Emotional Development
- Child Abuse and Trauma
- Bullying, Victimization, and Aggression
- Health disparities and outcomes
- Epigenetics and DNA Methylation
- Attention Deficit Hyperactivity Disorder
- Schizophrenia research and treatment
- Cognitive Abilities and Testing
- Birth, Development, and Health
- Stress Responses and Cortisol
- Genetic Associations and Epidemiology
- Cannabis and Cannabinoid Research
- Health, Environment, Cognitive Aging
- Tryptophan and brain disorders
- Early Childhood Education and Development
- Migration, Health and Trauma
- Suicide and Self-Harm Studies
- Bipolar Disorder and Treatment
- Child Development and Digital Technology
- Intimate Partner and Family Violence
- Functional Brain Connectivity Studies
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Adolescent and Pediatric Healthcare
- Psychological Well-being and Life Satisfaction
- Homelessness and Social Issues
King's College London
2016-2025
University of the West of England
2024
Duke University
2012-2021
Economic and Social Research Council
2020-2021
South London and Maudsley NHS Foundation Trust
2016-2018
National Center for Injury Prevention and Control
2018
Centers for Disease Control and Prevention
2018
Cardiff University
2018
University of Bristol
2018
National Research Tomsk State University
2018
Policy-makers are considering large-scale programs aimed at self-control to improve citizens’ health and wealth reduce crime. Experimental economic studies suggest such could reap benefits. Yet, is important for the health, wealth, public safety of population? Following a cohort 1,000 children from birth age 32 y, we show that childhood predicts physical substance dependence, personal finances, criminal offending outcomes, following gradient self-control. Effects children's be disentangled...
A mycoplasma-encoded purine nucleoside phosphorylase (designated PNP<sub>Hyor</sub>) has been cloned and characterized for the first time. Efficient phosphorolysis of natural 6-oxopurine 6-aminopurine nucleosides was observed, with adenosine preferred substrate (<i>K</i><sub>m</sub> = 61 <i>µ</i>M). Several cytostatic analogs proved to be susceptible PNP<sub>Hyor</sub>-mediated phosphorolysis, a markedly decreased or increased activity observed in <i>Mycoplasma hyorhinis</i>–infected human...
A five decade-long nationwide study revealed that the impact of being bullied in childhood persists up to mid-life. The harmful effects extend beyond psychological distress lower levels education, physical and cognitive health problems, poor social functioning.
Background: We report on mental disorders and violence for a birth cohort of young adults, regardless their contact with the health or justice systems. Methods:We studied 961 adults who constituted 94% total-city in New Zealand, April 1, 1972, through March 31, 1973.Past-year prevalence was measured using standardized DSM-III-R interviews.Past-year self-reports criminal offending search official conviction records.We also tested whether substance use before violent offense, adolescent...
OBJECTIVE. It has been shown that bullying victimization is associated with behavior and school adjustment problems, but it remains unclear whether the experience of uniquely contributes to those problems after taking into account preexisting problems. METHODS. We examined in Environmental Risk Study, a nationally representative 1994–1995 birth cohort 2232 children. identified children who experienced between ages 5 7 years either as pure victims or bully/victims. collected reports from...
Objective: Using longitudinal and prospective measures of trauma during childhood, the authors assessed risk developing psychotic symptoms associated with maltreatment, bullying, accidents in a nationally representative U.K. cohort young twins. Method: Data were from Environmental Risk Longitudinal Twin Study, which follows 2,232 twin children their families. Mothers interviewed home visits when ages 5, 7, 10, 12 on whether had experienced maltreatment by an adult, bullying peers, or...
If maternal expressed emotion is an environmental risk factor for children's antisocial behavior problems, it should account behavioral differences between siblings growing up in the same family even after genetic influences on problems are taken into account. This hypothesis was tested Environmental Risk Longitudinal Twin Study with a nationally representative 1994-1995 birth cohort of twins. The authors interviewed mothers 565 five-year-old monozygotic (MZ) twin pairs and established which...
Measures to quantify changes in the pace of biological aging response intervention are needed evaluate geroprotective interventions for humans. Previously, we showed that quantification from a DNA-methylation blood test was possible (Belsky et al., 2020). Here, report next-generation biomarker Pace Aging, DunedinPACE (for Aging Calculated Epigenome).
To investigate the association between social isolation and loneliness, how they relate to depression, whether these associations are explained by genetic influences. We used data from age-18 wave of Environmental Risk Longitudinal Twin Study, a birth cohort 1116 same-sex twin pairs born in England Wales 1994 1995. Participants reported on their levels isolation, loneliness depressive symptoms. conducted regression analyses test differential with depression. Using study design, we estimated...
Epidemiological research has shown that hallucinations and delusions, the classic symptoms of psychosis, are far more prevalent in population than actual psychotic disorder. These especially childhood adolescence. Longitudinal demonstrated adolescence increase risk disorder adulthood. There been a lack research, however, on immediate clinicopathological significance adolescence.To investigate relationship between non-psychotic psychopathology community samples adolescents terms prevalence,...
Biological aging is the gradual, progressive decline in system integrity that occurs with advancing chronological age, causing morbidity and disability. Measurements of pace are needed as surrogate endpoints trials therapies designed to prevent disease by slowing biological aging. We report a blood-DNA-methylation measure sensitive variation among individuals born same year. first modeled change-over-time 18 biomarkers tracking organ-system across 12 years follow-up n = 954 members Dunedin...
Bullied children are at risk for later emotional and behavioural problems. 'Resilient' function better than would be expected given their experience of bullying victimisation. This study examined the role families in promoting resilience following victimisation primary school.Data were from Environmental Risk (E-Risk) Study which describes a nationally representative sample 1,116 twin pairs families. We used mothers' children's reports to examine during school teachers' measure adjustment...
Attention-deficit/hyperactivity disorder (ADHD) is now recognized to occur in adulthood and associated with a range of negative outcomes. However, less known about the prospective course ADHD into adulthood, risk factors for its persistence, possibility emergence young nonclinical populations.
Despite the emphasis placed on childhood trauma in psychiatry, comparatively little is known about epidemiology of and trauma-related psychopathology young people. We therefore aimed to evaluate prevalence, clinical features, risk factors associated with exposure post-traumatic stress disorder (PTSD)
Both prospective informant-reports and retrospective self-reports may be used to measure childhood maltreatment, though both methods entail potential limitations such as underestimation memory biases. The validity utility of standard measures maltreatment requires clarification in order inform the design future studies investigating mental health consequences maltreatment. present study assessed agreement between well comparative reports for predicting a range psychiatric problems at age 18....
Abstract Background The aim of this study was to build a detailed, integrative profile the correlates young adults’ feelings loneliness, in terms their current health and functioning childhood experiences circumstances. Methods Data were drawn from Environmental Risk Longitudinal Twin Study, birth cohort 2232 individuals born England Wales 1994 1995. Loneliness measured when participants aged 18. Regression analyses used test concurrent associations between loneliness adulthood. conducted...