Eva Giralt‐Steinhauer
A5071923991- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Epigenetics and DNA Methylation
- Atrial Fibrillation Management and Outcomes
- Genetic Associations and Epidemiology
- Venous Thromboembolism Diagnosis and Management
- Cancer-related gene regulation
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Cerebral Venous Sinus Thrombosis
- Kruppel-like factors research
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Advanced MRI Techniques and Applications
- Alcohol Consumption and Health Effects
- Neurological and metabolic disorders
- Genetic Syndromes and Imprinting
- Intergenerational Family Dynamics and Caregiving
- Cerebrovascular and genetic disorders
- Dementia and Cognitive Impairment Research
- Migraine and Headache Studies
- Genomics and Rare Diseases
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Peripheral Artery Disease Management
Hospital del Mar Research Institute
2016-2025
Municipal Institute for Medical Research
2016-2025
Hospital Del Mar
2016-2025
Universitat Pompeu Fabra
2014-2024
Biomedical Research Institute of Lleida
2024
Universitat Autònoma de Barcelona
2013-2022
Clinical Trial Investigators
2022
Parc de Salut
2017-2022
Broad Institute
2012-2020
Harvard University
2014-2020
Type 2 diabetes mellitus (DM) is an established risk factor for a wide range of vascular diseases, including ischemic stroke (IS). Glycated hemoglobin A1c (HbA1c), marker average blood glucose levels over the previous 12 weeks, used as measure glycemic control and also diagnostic criterion (HbA1c ≥ 6.5%). Epigenetic mechanisms, such DNA methylation, may be associated with aging processes modulation various pathologies, DM. Specifically, methylation could one mechanisms mediating relation...
Background and Purpose— Previous studies suggest that genetic variation plays a substantial role in occurrence evolution of intracerebral hemorrhage (ICH). Genetic contribution to disease can be determined by calculating heritability using family-based data, but such an approach is impractical for ICH because lack large pedigree-based studies. However, novel analytic tool based on genome-wide data allows estimation from unrelated subjects. We sought apply this method provide estimates risk,...
<h3>Objective:</h3> Little information is available about sex-related differences in intracerebral hemorrhage (ICH). This a prospective observational study to describe the sex demographics, vascular risk factors, stroke care, and outcomes primary ICH. <h3>Methods:</h3> BasicMar hospital-based registry of all patients admitted single public hospital that covers population 330,000. From 2005 2015, there were 515 consecutive acute ICH patients. Outcome data obtained at 3 months....
The risk of stroke recurrence in patients with Embolic Stroke Undetermined Source (ESUS) is high, and the optimal antithrombotic strategy for secondary prevention unclear. We investigated whether congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, or transient ischemic attack (TIA; CHADS2) CHA2DS2-VASc scores can stratify long-term stroke/TIA death ESUS.We pooled data sets 11 registries from Europe America. ESUS was defined according to Cryptogenic Stroke/ESUS...
To analyze the effect of age-related DNA methylation changes in multiple cytosine-phosphate-guanine (CpG) sites (biological age [b-age]) on patient outcomes at 3 months after an ischemic stroke.We included 511 patients with first-ever acute stroke assessed Hospital del Mar (Barcelona, Spain) as discovery cohort. Demographic and clinical data, including chronological (c-age), vascular risk factors, initial severity, recanalization treatment, previous 3-month modified Rankin Scale (p-mRS...
Age and stroke severity are the main mortality predictors after ischemic stroke. However, chronological age biological not exactly concordant. Age-related changes in DNA methylation multiple CpG sites across genome can be used to estimate age, which is influenced by lifestyle, environmental factors, genetic variation. We analyzed impact of on 3-month assessed 594 patients with acute a cohort from Hospital del Mar (Barcelona) validated results an independent cohort. Demographic clinical data,...
Ischemic stroke is associated with aging. It possible to predict chronological age by measuring age-related changes in DNA methylation from multiple CpG sites across the genome, known as biological age. The difference between and actual would indicate an individual's level of Our aim was determine ischemic patients compare their aging controls same A total 123 individuals, 41 82 were paired age, ranging 39 years. Illumina HumanMethylation450 BeadChip array used measure both groups, estimated...
To describe short-term and 5-year rates of mortality poor outcome in patients with spontaneous aneurysmal subarachnoid hemorrhage (aSAH) who received repair treatment.
To assess the relationship between short-term exposure to outdoor ambient air pollutants (fine particulate matter [PM2.5] and black carbon [BC]), ischemic stroke (IS) its different subtypes, potential modifying effect of neighborhood greenspace noise. This time-stratified case-crossover study was based on IS transient attacks (TIA) recorded in a hospital-based prospective register (BASICMAR 2005-2014) Barcelona (Catalonia, Spain). Daily hourly pollutant concentrations meteorological data...
To examine etiologic stroke subtypes and vascular risk factor profiles their association with white matter hyperintensity (WMH) burden in patients hospitalized for acute ischemic (AIS).
Background and Purpose: Large-scale observational studies of acute ischemic stroke (AIS) promise to reveal mechanisms underlying cerebral ischemia. However, meaningful quantitative phenotypes attainable in large patient populations are needed. We characterize a dynamic metric AIS instability, defined by change National Institutes Health Stroke Scale score (NIHSS) from baseline 24 hours (NIHSS – NIHSS 24hours = ΔNIHSS 6-24h ), examine its relevance long-term outcomes. Methods: Patients with...
Abstract Background and aims Stroke is the leading cause of adult-onset disability. Although clinical factors influence stroke outcome, there a significant variability among individuals that may be attributed to genetics epigenetics, including DNA methylation (DNAm). We aimed study association between DNAm prognosis. Methods results To aim, we conducted two-phase (discovery-replication meta-analysis) in Caucasian patients with ischemic from two independent centers (BasicMar [discovery, N =...
Introduction: Prior clinical trials of oral anticoagulant (OAC) reversal have demonstrated improved outcomes in patients with OAC-related intracerebral hemorrhage (ICH). However, despite guidelines recommend avoiding the withdrawal medical support within first 2 days, about a quarter ICH do not receive an OAC agent. We aimed to determine factors predictive administration agent these patients. Methods: Prespecified analysis from Anticoagulant-Related (ARICH) registry, multicenter,...
Importance After a transient ischemic attack (TIA) or minor stroke, the long-term risk of stroke is not well-known. Objective To determine annual incidence rates and cumulative incidences up to 10 years after TIA stroke. Data Sources MEDLINE, Embase, Web Science were searched from inception through June 26, 2024. Study Selection Prospective retrospective cohort studies reporting during minimum follow-up 1 year in patients with Extraction Synthesis Two reviewers independently performed data...
Ischemic stroke (IS), a heterogeneous multifactorial disorder, is among the leading causes of mortality and long-term disability in western world. Epidemiological data provides evidence for genetic component to disease, but its epigenetic involvement still largely unknown. Epigenetic mechanisms, such as DNA methylation, change over time may be associated with aging processes modulation risk various pathologies, cardiovascular disease stroke. We analyzed 2 independent cohorts IS patients....
NINDS (National Institute of Neurological Disorders and Stroke)-SiGN (Stroke Genetics Network) is an international consortium ischemic stroke studies that aims to generate high-quality phenotype data identify the genetic basis pathogenic subtypes. This analysis characterizes etiopathogenetic reliability classification in consortium.