Kristel van Eijk
A5071065333- Genetic Associations and Epidemiology
- Functional Brain Connectivity Studies
- Epigenetics and DNA Methylation
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Neurological diseases and metabolism
- Neural dynamics and brain function
- Transcranial Magnetic Stimulation Studies
- Bipolar Disorder and Treatment
- EEG and Brain-Computer Interfaces
- Health Systems, Economic Evaluations, Quality of Life
- Bioinformatics and Genomic Networks
- Genetic Syndromes and Imprinting
- Mental Health Research Topics
- Receptor Mechanisms and Signaling
- Viral Infections and Immunology Research
- Spinal Cord Injury Research
- Cardiac Structural Anomalies and Repair
- Kawasaki Disease and Coronary Complications
- Cardiac electrophysiology and arrhythmias
- Adenosine and Purinergic Signaling
- Health, Environment, Cognitive Aging
- Linguistics and Cultural Studies
- Schizophrenia research and treatment
- Phosphodiesterase function and regulation
University Medical Center Utrecht
2012-2024
Utrecht University
2020-2023
University of Amsterdam
2021
Ziekenhuisnetwerk Antwerpen Stuivenberg
2021
SIB Swiss Institute of Bioinformatics
2009
European Bioinformatics Institute
2009
Wellcome Trust
2009
Several recent studies reported aging effects on DNA methylation levels of individual CpG dinucleotides. But it is not yet known whether aging-related consensus modules, in the form clusters correlated markers, can be found that are present multiple human tissues. Such a module could facilitate understanding tissues.We therefore employed weighted correlation network analysis 2,442 Illumina arrays from brain and blood tissues, which enabled identification an age-related co-methylation module....
IntAct is an open-source, open data molecular interaction database and toolkit. Data abstracted from the literature or direct depositions by expert curators following a deep annotation model providing high level of detail. As September 2009, contains over 200.000 curated binary evidences. In response to growing volume user requests, now provides two-tiered view data. The search interface allows iteratively develop complex queries, exploiting detailed with hierarchical controlled...
With the advent of gene therapies for amyotrophic lateral sclerosis (ALS), there is a surge in testing this disease. Although ample experience with C9orf72, SOD1, FUS and TARDBP familial ALS, large studies exploring genetic variation all ALS-associated genes sporadic ALS (sALS) are still scarce. Gene diagnostic setting challenging, given complex architecture sALS, which variants small effect sizes. Guidelines interpretation panels counselling patients lacking. We aimed to provide thorough...
Cancer genetics has to date focused on epithelial malignancies, identifying multiple histotype-specific pathways underlying cancer susceptibility. Sarcomas are rare malignancies predominantly derived from embryonic mesoderm. To identify specific mesenchymal cancers, we performed whole-genome germline sequencing 1644 sporadic cases and 3205 matched healthy elderly controls. Using an extreme phenotype design, a combined rare-variant burden ontologic analysis identified two sarcoma-specific...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving selective vulnerability of energy-intensive motor neurons (MNs). It has been unclear whether mitochondrial function an upstream driver or downstream modifier neurotoxicity. We separated genetic determinants function, including variation within the genome autosomes; from changeable factors DNA copy number (mtCN). Across three cohorts 6,437 ALS patients, we discovered that set haplotypes, chosen because they are...
Predictors consistently associated with psychosis liability and course of illness in schizophrenia (SCZ) spectrum disorders (SSD), including the need for clozapine treatment, are lacking. Longitudinally ascertained medication use may empower studies examining associations between polygenic risk scores (PRSs) pharmacotherapy choices.To examine PRS-SCZ loading groups different liabilities to SSD (individuals taking clozapine, individuals other antipsychotics, their parents siblings, unrelated...
Abstract Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and disease. Here we describe results of methylation-quantitative trait loci (mQTL) analyses 32,851 participants, identifying variants associated with DNAm at 420,509 sites in blood. We present a database >270,000 independent mQTL which 8.5% comprise long-range ( trans ) associations. Identified associations explain 15-17% the additive variance...
The treatment of major depressive disorder (MDD) is hampered by low chances response in each step, which partly due to a lack firmly established outcome-predictive biomarkers. Here, we hypothesize that polygenic-informed EEG signatures may help predict antidepressant response. Using electroencephalography (EEG) data-driven, data-reduction approach, identify brain network large cohort (N=1,123), and discover it sex-specifically (male patients, N=617) associated with polygenic risk score (PRS)...
The role of the survival motor neuron (SMN) gene in amyotrophic lateral sclerosis (ALS) is unclear, with several conflicting reports. A decisive result on this topic needed, given that treatment options are available now for SMN deficiency.
The relative merits of sequential bypass grafting were compared to those conventional in 247 patients undergoing uncomplicated coronary artery graft surgery. duration both ischemic arrest and cardiopulmonary could be predicted on the basis number end-to-side side-to-side anastomoses. Multivariate regression showed that can executed more quickly than because: 1. suture time for anastomoses is less (5 vs. 12 min) and, 2. fewer aortic are required. rate perioperative myocardial infarction was...
Abstract The treatment of major depressive disorder (MDD) is hampered by low chances response in each step, which partly due to a lack firmly established outcome-predictive biomarkers. Here, we hypothesize that polygenic-informed EEG biomarkers may help predict differential antidepressant response. Using electroencephalography (EEG) data-driven, data-reduction approach, identify functional brain network sex-specifically associated with polygenic risk for MDD psychiatric patients (N=1,123)....
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Selective vulnerability of energy-intensive motor neurons (MNs) has fostered speculation that mitochondrial function determinant ALS. Previously, the position in pathogenic cascade leading to neurotoxicity been unclear. We separated upstream genetic determinants function, including variation within genome or autosomes; from downstream changeable factors copy number (mtCN) and MN gene expression. discovered...
Abstract The treatment of major depressive disorder (MDD) is hampered by low chances response in each step, which partly due to a lack firmly established outcome-predictive biomarkers. Here, we hypothesize that polygenic-informed EEG signatures may help predict differential antidepressant response. Using electroencephalography (EEG) data-driven, data-reduction approach, identify functional brain network large cohort predominantly psychiatric patients (N=1,123), and discover this...