A5027676865- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Treatment of Major Depression
- Neural and Behavioral Psychology Studies
- Child and Adolescent Psychosocial and Emotional Development
- Genetic Associations and Epidemiology
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Schizophrenia research and treatment
- Advanced MRI Techniques and Applications
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Psychosomatic Disorders and Their Treatments
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Child Abuse and Trauma
- Bipolar Disorder and Treatment
- Neuroscience and Music Perception
- Genetics and Neurodevelopmental Disorders
- Attention Deficit Hyperactivity Disorder
- Transcranial Magnetic Stimulation Studies
- Epigenetics and DNA Methylation
- Amyotrophic Lateral Sclerosis Research
- Neurobiology of Language and Bilingualism
- Health, Environment, Cognitive Aging
University Medical Center Groningen
2015-2024
University of Groningen
2015-2024
University Medical Center Utrecht
2014-2019
Charité - Universitätsmedizin Berlin
2019
Hôpital Albert-Chenevier
2019
Inserm
2019
National Institute of Mental Health
2019
Ludwig-Maximilians-Universität München
2019
University of Campania "Luigi Vanvitelli"
2019
Humanitas University
2019
<h3>Context</h3> Major depressive disorder (MDD), panic disorder, and social anxiety are among the most prevalent frequently co-occurring psychiatric disorders in adults may have, at least part, a common etiology. <h3>Objective</h3> To identify unique shared neuroanatomical profile of depression anxiety, controlling for illness severity, medication use, sex, age onset, recurrence. <h3>Design</h3> Cross-sectional study. <h3>Setting</h3> Netherlands Study Depression Anxiety....
Alterations in white matter (WM) microstructure have been implicated the pathophysiology of major depressive disorder (MDD). However, previous findings inconsistent, partially due to low statistical power and heterogeneity depression. In largest multi-site study date, we examined WM anisotropy diffusivity 1305 MDD patients 1602 healthy controls (age range 12–88 years) from 20 samples worldwide, which included both adults adolescents, within Working Group Enhancing Neuroimaging Genetics...
Psychiatric disorders are highly heterogeneous, defined based on symptoms with little connection to potential underlying biological mechanisms. A possible approach dissect heterogeneity is look for biologically meaningful subtypes. recent study Drysdale et al. (2017) showed promising results along this line by simultaneously using resting state fMRI and clinical data identified four distinct subtypes of depression different profiles abnormal connectivity. These were predictive treatment...
Abstract Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced aging in adult MDD patients, whether this process clinical characteristics a large multicenter international dataset. performed mega-analysis by pooling measures derived from T1-weighted MRI scans 19 samples worldwide. Healthy was estimated predicting chronological age (18–75 years) 7 subcortical volumes, 34 cortical thickness...
In the context of chronic childhood emotional maltreatment (CEM; abuse and/or neglect), adequately responding to facial expressions is an important skill. Over time, however, this adaptive response may lead a persistent vigilance for expressions. The amygdala and medial prefrontal cortex (mPFC) are key regions in face processing. However, neurobiological correlates processing adults reporting CEM yet unknown. We examined amydala mPFC reactivity faces (Angry, Fearful, Sad, Happy, Neutral) vs...
Background: Impaired insight is a common feature in psychosis and an important predictor of variables such as functional outcome, prognosis, treatment adherence. A cognitive process that may underlie self-reflection, or the conscious evaluation one’s traits characteristics. The current study aims to investigate neural correlates self-reflective processing its relationship with schizophrenia. Methods: Forty-seven schizophrenia patients 21 healthy controls performed self-reflection task...
Functional magnetic resonance imaging (fMRI) studies have shown that anatomically distinct brain regions are functionally connected during the resting state. Basic topological properties in functional connectivity (BFC) map highlighted BFC's small-world topology. Modularity, a more advanced property, has been hypothesized to be evolutionary advantageous, contributing adaptive aspects of anatomical and connectivity. However, current definitions modularity for complex networks focus on...
The neurobiology of social anxiety disorder (SAD) is not yet fully understood. Structural and functional neuroimaging studies in SAD have identified abnormalities various brain areas, particularly the amygdala elements salience network. This study first to examine resting-state connectivity a drug-naive sample patients without psychiatric comorbidity healthy controls, using seed regions interest bilateral amygdala, dorsal anterior cingulate cortex for network, posterior default mode Twelve...
Background Childhood emotional maltreatment (CEM) has been associated with disturbances in and behavioral functioning, changes regional brain morphology. However, whether CEM any effect on the intrinsic organization of is not known. In this study, we investigated effects resting-state functional connectivity (RSFC) using seeds limbic network, default-mode network (DMN) salience left dorsomedial prefrontal cortex (dmPFC). Method Using 3-T magnetic resonance imaging (MRI), MRI (RS-fMRI) scans...
Neuroticism and extraversion are personality factors associated with the vulnerability for developing depression anxiety disorders, possibly differentially related to brain structures implicated in processing of emotional information generation mood states. To date, studies on morphology mainly focused neuroticism, a dimension primarily negative affect, yielding conflicting findings concerning association personality, partially due methodological issues variable population samples under...
Background Local structural and metabolic as well inter-regional connectivity abnormalities have been implicated in the neuropathology of major depressive disorder (MDD). How local tissue properties affect intrinsic functional is, however, unclear. Using a cross-sectional, multi-modal imaging approach, we investigated relationship between cortical resting-state (RSFC) MDD. Method A total 20 MDD in-patients healthy controls underwent magnetic resonance at 3 T for imaging. Whole-brain...
BackgroundA chronic course of major depressive disorder (MDD) is associated with profound alterations in brain volumes and emotional cognitive processing. However, no neurobiological markers have been identified that prospectively predict MDD trajectories. This study evaluated the prognostic value different neuroimaging modalities, clinical characteristics, their combination to classify trajectories.MethodsOne hundred eighteen patients underwent structural functional magnetic resonance...
Childhood emotional maltreatment (CEM) has adverse effects on medial prefrontal cortex (mPFC) morphology, a structure that is crucial for cognitive functioning and (emotional) memory which modulates the limbic system. In addition, CEM been linked to amygdala hyperactivity during face processing. However, no study yet investigated functional neural correlates of neutral in adults reporting CEM. Using magnetic resonance imaging, we CEM-related differential activations mPFC encoding recognition...