Lorna M. Lopez

ORCID: 0000-0002-0241-9783
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About
Contact & Profiles
Research Areas
  • Genetic Associations and Epidemiology
  • Alzheimer's disease research and treatments
  • Epigenetics and DNA Methylation
  • Genetics and Neurodevelopmental Disorders
  • Bioinformatics and Genomic Networks
  • Genomic variations and chromosomal abnormalities
  • Cognitive Abilities and Testing
  • Birth, Development, and Health
  • Health, Environment, Cognitive Aging
  • Advanced Neuroimaging Techniques and Applications
  • Tryptophan and brain disorders
  • Diet and metabolism studies
  • Hormonal Regulation and Hypertension
  • Nutrition, Genetics, and Disease
  • Folate and B Vitamins Research
  • Neurological Disease Mechanisms and Treatments
  • Autism Spectrum Disorder Research
  • Genomics and Rare Diseases
  • Dementia and Cognitive Impairment Research
  • Bipolar Disorder and Treatment
  • Neuroscience and Neuropharmacology Research
  • Gout, Hyperuricemia, Uric Acid
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Amyotrophic Lateral Sclerosis Research
  • Blood Coagulation and Thrombosis Mechanisms

University of Pittsburgh
2011-2025

National University of Ireland, Maynooth
2020-2024

University Health Network
2014-2023

Trinity College Dublin
2019-2021

Institute of Molecular Medicine
2019

University of Edinburgh
2009-2018

Beaumont Hospital
2015-2018

Royal College of Surgeons in Ireland
2014-2018

University College Dublin
2015-2017

Royal College of Surgeons of England
2017

Valentina Escott‐Price Céline Bellenguez Li‐San Wang Seung‐Hoan Choi Denise Harold and 95 more Lesley Jones Peter Holmans Amy Gerrish Alexey Vedernikov Alexander Richards Anita L. DeStefano Jean‐Charles Lambert Carla A. Ibrahim‐Verbaas Adam C. Naj Rebecca Sims Gyungah Jun Joshua C. Bis Gary W. Beecham Benjamin Grenier‐Boley Giancarlo Russo Tricia A. Thornton‐Wells Nicola Denning Albert V. Smith Vincent Chouraki Charlene Thomas M. Arfan Ikram Diana Zélénika Badri N. Vardarajan Yoichiro Kamatani Chiao‐Feng Lin Helena Schmidt Brian W. Kunkle Melanie Dunstan Maria Vronskaya Andrew D. Johnson Agustı́n Ruiz Marie‐Thérèse Bihoreau Christiane Reitz Florence Pasquier Paul Hollingworth Olivier Hanon Annette L. Fitzpatrick Joseph D. Buxbaum Dominique Campion Paul K. Crane Clinton T. Baldwin Tim Becker Vilmundur Guðnason Carlos Cruchaga David Craig Najaf Amin Claudine Berr Lorna M. Lopez Philip L. De Jager Vincent Deramecourt Janet Johnston Denis A. Evans Simon Lovestone Luc Letenneur Isabel Hernández David C. Rubinsztein Gudny Eiriksdottir Kristel Sleegers Alison Goate Nathalie Fiévet Matthew J. Huentelman Michael Gill Kristelle Brown M. Ilyas Kamboh Lina Keller Pascale Barberger‐Gateau Bernadette McGuinness Eric B. Larson Amanda Myers Carole Dufouil Stephen Todd David Wallon Seth Love Ekaterina Rogaeva John Gallacher Peter St George‐Hyslop Jordi Clarimón Alberto Lleó Antony Bayer Debby W. Tsuang Lei Yu Magda Tsolaki Paola Bossù Gianfranco Spalletta Petroula Proitsi John Collinge Sandro Sorbi Florentino Sanchez‐García Nick C. Fox John Hardy María Cándida Déniz Naranjo Paolo Bosco Robert Clarke Carol Brayne Daniela Galimberti

Background Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought identify new genes, using an alternative gene-wide analytical approach tests patterns of association within in the powerful genome-wide dataset International Genomics Project Consortium, comprising over 7 m genotypes from 25,580 cases and 48,466 controls. Principal Findings In addition...

10.1371/journal.pone.0094661 article EN cc-by PLoS ONE 2014-06-12
Derrek P. Hibar Jason L. Stein Miguel E. Rentería Alejandro Arias Väsquez Sylvane Desrivières and 95 more Neda Jahanshad Roberto Toro Katharina Wittfeld Lucija Abramovic Micael Andersson Benjamin S. Aribisala Nicola J. Armstrong Manon Bernard Marc M. Bohlken Marco P. Boks Janita Bralten Andrew Brown M. Mallar Chakravarty Qiang Chen Christopher R. K. Ching Gabriel Cuéllar-Partida Anouk den Braber Sudheer Giddaluru Aaron L. Goldman O. Grimm Tulio Guadalupe Johanna Haß Girma Woldehawariat Avram J. Holmes Martine Hoogman Deborah Janowitz Tianye Jia Sungeun Kim Marieke Klein Bernd Kraemer Phil H. Lee Loes M. Olde Loohuis Michelle Luciano Christine Macare Karen A. Mather Manuel Mattheisen Yuri Milaneschi Kwangsik Nho Martina Papmeyer Adaikalavan Ramasamy Shannon L. Risacher Roberto Roiz‐Santiáñez Emma J. Rose Alireza Salami Philipp G. Sämann Lianne Schmaal Andrew J. Schork Jean Shin Lachlan T. Strike Alexander Teumer Marjolein M. J. van Donkelaar Kristel R. van Eijk James Walters Lars T. Westlye Christopher D. Whelan Anderson M. Winkler Marcel P. Zwiers Saud Alhusaini Lavinia Athanasiu Stefan Ehrlich Marina Hakobjan Cecilie B. Hartberg Unn K. Haukvik Angelien J.G.A.M. Heister David Hoehn Dalia Kasperavičiūtė David C. Liewald Lorna M. Lopez Remco R. Makkinje Mar Matarín Marlies Naber Dean McKay Margaret Needham Allison C. Nugent Benno Pütz Natalie A. Royle Li Shen Emma Sprooten Daniah Trabzuni Saskia S. L. van der Marel K.J.E. van Hulzen Esther Walton Christiane Wolf Laura Almasy David Ames Sampath Arepalli Amelia A. Assareh Mark E. Bastin Henry Brodaty Kazima Bulayeva Melanie A. Carless Sven Cichon Aiden Corvin Joanne E. Curran Michael Czisch

10.1038/nature14101 article EN Nature 2015-01-20
Jason L. Stein Sarah E. Medland Alejandro Arias Väsquez Derrek P. Hibar Rudy E Senstad and 95 more Anderson M. Winkler Roberto Toro Katja Appel Richard Barteček Ørjan Bergmann Manon Bernard Andrew Brown Dara M. Cannon M. Mallar Chakravarty Andrea Christoforou Martin Domín O. Grimm Marisa O. Hollinshead Avram J. Holmes Georg Homuth Jouke‐Jan Hottenga Camilla Langan Lorna M. Lopez Narelle K. Hansell Kristy Hwang Sungeun Kim Gonzalo Laje Phil H. Lee Xinmin Liu Eva Loth Anbarasu Lourdusamy Morten Mattingsdal Sebastian Mohnke Susana Muñoz Maniega Kwangsik Nho Allison C. Nugent Carol O’Brien Martina Papmeyer Benno Pütz Adaikalavan Ramasamy Jerod M. Rasmussen Mark Rijpkema Shannon L. Risacher J. Cooper Roddey Emma J. Rose Mina Ryten Li Shen Emma Sprooten Eric Strengman Alexander Teumer Daniah Trabzuni Jessica A. Turner Kristel van Eijk Theo G.M. van Erp Marie‐José van Tol Katharina Wittfeld Christiane Wolf Saskia Woudstra André Alemán Saud Alhusaini Laura Almasy Elisabeth B. Binder David G. Brohawn Rita M. Cantor Melanie A. Carless Aiden Corvin Michael Czisch Joanne E. Curran Gail Davies Marcio Almeida Norman Delanty Chantal Depondt Ravi Duggirala Thomas D. Dyer Susanne Erk Jesen Fagerness Peter T. Fox Nelson B. Freimer Michael Gill Harald H.H. Göring Donald J. Hagler David Hoehn Herta Flor Martine Hoogman Norbert Hosten Neda Jahanshad Matthew P. Johnson Dalia Kasperavičiūtė Jack W. Kent Peter Kochunov Jack L. Lancaster Stephen M. Lawrie David C. Liewald René C.W. Mandl Mar Matarín Manuel Mattheisen Eva Meisenzahl Ingrid Melle Eric K. Moses Thomas W. Mühleisen

10.1038/ng.2250 article EN Nature Genetics 2012-04-15
María Soler Artigas Daan W. Loth Louise V. Wain Sina A. Gharib Ma’en Obeidat and 95 more Wenbo Tang Guangju Zhai Wei Zhao Albert V. Smith Jennifer E. Huffman Eva Albrecht Catherine Jackson David M. Evans Gemma Cadby Myriam Fornage Ani Manichaikul Lorna M. Lopez Toby Johnson Melinda C. Aldrich Thor Aspelund Inês Barroso Harry Campbell Patricia A. Cassano David Couper Guðný Eiríksdóttir Nora Franceschini Melissa García Christian Gieger Gauti Kjartan Gíslason Ivica Grković Christopher J. Hammond Dana B. Hancock Tamara B. Harris Adaikalavan Ramasamy Susan R. Heckbert Markku Heliövaara Georg Homuth Pirro G. Hysi Anthony James Stipan Janković Bonnie R. Joubert Stefan Karrasch Norman Klopp Beate Koch Stephen B. Kritchevsky Lenore J. Launer Yongmei Liu Laura R. Loehr Kurt Lohman Ruth J. F. Loos Thomas Lumley Khalid A Al Balushi Wei Ang R. Graham Barr John Beilby John Blakey Mladen Boban Vesna Boraska Perica Jonas Brisman John Britton Guy Brusselle Cyrus Cooper Ivan Curjuric Santosh Dahgam Ian J. Deary Shah Ebrahim Mark Eijgelsheim Clyde Francks Darya Gaysina Raquel Granell Xiangjun Gu John Hankinson Rebecca Hardy Sarah E. Harris John Henderson Amanda P. Henry Aroon D. Hingorani Albert Hofman Patrick G. Holt Jennie Hui Michael Hunter Medea Imboden Anthony James Shona M. Kerr Ivana Kolčić Florian Kronenberg Jason Z. Liu Jonathan Marchini Tricia M. McKeever Andrew D. Morris Anna-Carin Olin David J. Porteous Dirkje S. Postma Stephen S. Rich Susan M. Ring Fernando Rivadeneira Thierry Rochat Avan Aihie Sayer Ian Sayers Peter D. Sly

10.1038/ng.941 article EN Nature Genetics 2011-09-25
Pim van der Harst Weihua Zhang Irene Mateo Leach Augusto Rendon Niek Verweij and 95 more Joban Sehmi Dirk S. Paul Ulrich Elling Hooman Allayee Man Li Aparna Radhakrishnan Sian-Tsung Tan Katrin Voß Christian X. Weichenberger Cornelis A. Albers Abtehale Al-Hussani Folkert W. Asselbergs Marina Ciullo Fabrice Danjou Christian Dina Tõnu Esko David M. Evans Lude Franke Martin Gögele Jaana Hartiala Micha Hersch Hilma Hólm Jouke‐Jan Hottenga Stavroula Kanoni Marcus E. Kleber Vasiliki Lagou Claudia Langenberg Lorna M. Lopez Leo‐Pekka Lyytikäinen Olle Melander Federico Murgia Ilja M. Nolte Paul F. O’Reilly Sandosh Padmanabhan Afshin Parsa Nicola Pirastu Eleonora Porcu Laura Portas Inga Prokopenko Janina S. Ried So-Youn Shin Clara Sze-Man Tang Alexander Teumer Michela Traglia Sheila Ulivi Harm-Jan Westra Jian Yang Wei Zhao Franco Anni Abdel Abdellaoui Antony Attwood Beverley Balkau Stefania Bandinelli François Bastardot Beben Benyamin Bernhard O. Boehm William Cookson Debashish Das Paul I. W. de Bakker Rudolf A. de Boer Eco J. C. de Geus Marleen H. M. de Moor Maria Dimitriou Francisco S. Domingues Angela Döring Gunnar Engström Guðmundur I. Eyjólfsson Luigi Ferrucci Krista Fischer Renzo Galanello Stephen F. Garner Bernd Genser Quince Gibson Giorgia Girotto Daníel F. Guðbjartsson Sarah E. Harris Anna-Liisa Hartikainen Claire E. Hastie Bo Hedblad Thomas Illig Jennifer Jolley Mika Kähönen Ido P. Kema John P. Kemp Liming Liang Heather Lloyd-Jones Ruth J. F. Loos Stuart Meacham Sarah E. Medland Christa Meisinger Yasin Memari Evelin Mihailov Kathy Ann Miller Miriam F. Moffatt Matthias Nauck

10.1038/nature11677 article EN Nature 2012-12-01
Hieab H.H. Adams Derrek P. Hibar Vincent Chouraki Jason L. Stein Paul Nyquist and 95 more Miguel E. Rentería Stella Trompet Alejandro Arias Väsquez Sudha Seshadri Sylvane Desrivières Ashley Beecham Neda Jahanshad Katharina Wittfeld Sven J. van der Lee Lucija Abramovic Saud Alhusaini Najaf Amin Micael Andersson Konstantinos Arfanakis Benjamin S. Aribisala Nicola J. Armstrong Lavinia Athanasiu Tomas Axelsson Alexa S. Beiser Manon Bernard Joshua C. Bis Laura M. E. Blanken Susan H. Blanton Marc M. Bohlken Marco P. Boks Janita Bralten Adam M. Brickman Owen Carmichael M. Mallar Chakravarty Ganesh Chauhan Qiang Chen Christopher R. K. Ching Gabriel Cuéllar-Partida Anouk den Braber Nhat Trung Doan Stefan Ehrlich Irina Filippi Tian Ge Sudheer Giddaluru Aaron L. Goldman Rebecca F. Gottesman Corina U. Greven O. Grimm Michael Griswold Tulio Guadalupe Johanna Haß Unn K. Haukvik Saima Hilal Edith Hofer David Hoehn Avram J. Holmes Martine Hoogman Deborah Janowitz Tianye Jia Dalia Kasperavičiūtė Sung Eun Kim Marieke Klein Bernd Kraemer Phil H. Lee Jiemin Liao David C. Liewald Lorna M. Lopez Michelle Luciano Christine Macare André F. Marquand Mar Matarín Karen A. Mather Manuel Mattheisen Bernard Mazoyer David R. McKay Rebekah McWhirter Yuri Milaneschi Nazanin Mirza‐Schreiber Ryan L. Muetzel Susana Muñoz Maniega Kwangsik Nho Allison C. Nugent Loes M. Olde Loohuis Jaap Oosterlaan Martina Papmeyer Irene Pappa Lukas Pirpamer Sara Pudas Benno Pütz Kumar B. Rajan Adaikalavan Ramasamy Jennifer S. Richards Shannon L. Risacher Roberto Roiz‐Santiáñez Nanda Rommelse Emma J. Rose Natalie A. Royle Tatjana Rundek Philipp G. Sämann Claudia L. Satizábal

10.1038/nn.4398 article EN Nature Neuroscience 2016-10-03

10.1038/ng.2237 article EN Nature Genetics 2012-04-15
Benjamin F.J. Verhaaren Stéphanie Debette Joshua C. Bis Jennifer A. Smith M. Kamran Ikram and 95 more Hieab H.H. Adams Ashley Beecham Kumar B. Rajan Lorna M. Lopez Sandra Barral Mark A. van Buchem Jeroen van der Grond Albert V. Smith Katrin Hegenscheid Neelum T. Aggarwal Mariza de Andrade Elizabeth J. Atkinson Marian Beekman Alexa S. Beiser Susan H. Blanton Eric Boerwinkle Adam M. Brickman R. Nick Bryan Ganesh Chauhan Christopher Chen Vincent Chouraki Anton J. M. de Craen Fabrice Crivello Ian J. Deary Joris Deelen Philip L. De Jager Carole Dufouil Mitchell S.V. Elkind Denis A. Evans Paul Freudenberger Rebecca F. Gottesman Vilmundur Guðnason Mohamad Habes Susan R. Heckbert Gerardo Heiss Saima Hilal Edith Hofer Albert Hofman Carla A. Ibrahim‐Verbaas David S. Knopman Cora E. Lewis Jiemin Liao David C. Liewald Michelle Luciano Aad van der Lugt Oliver Martinez Richard Mayeux Bernard Mazoyer Mike A. Nalls Matthias Nauck Wiro J. Niessen Ben A. Oostra Bruce M. Psaty Kenneth Rice Jerome I. Rotter Bettina von Sarnowski Helena Schmidt Pamela J. Schreiner Maaike Schuur Stephen Sidney Sigurður Sigurðsson P. Eline Slagboom David J.M. Stott John C. van Swieten Alexander Teumer Anna Maria Töglhofer Matthew Traylor Stella Trompet Stephen T. Turner Christophe Tzourio Hae‐Won Uh André G. Uitterlinden Meike W. Vernooij Jing Jing Wang Tien Yin Wong Joanna M. Wardlaw B. Gwen Windham Katharina Wittfeld Christiane Wolf Clinton B. Wright Qiong Yang Wei Zhao Alex Zijdenbos J. Wouter Jukema Ralph L. Sacco Sharon L. R. Kardia Philippe Amouyel Thomas H. Mosley W. T. Longstreth Charles DeCarli Cornelia M. van Duijn Reinhold Schmidt Lenore J. Launer Hans J. Grabe Sudha Seshadri

Background— The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings incompletely characterized. To identify novel variants influencing burden, we conducted a meta-analysis multiethnic genome-wide association studies. Methods Results— We included 21 079 middle-aged to elderly individuals from 29 population-based cohorts, who were free dementia stroke European (n=17...

10.1161/circgenetics.114.000858 article EN Circulation Cardiovascular Genetics 2015-02-09
Louise V. Wain Ahmad Vaez Rick Jansen Roby Joehanes Peter J. van der Most and 95 more A. Mesut Erzurumluoglu Paul F. O’Reilly Claudia P. Cabrera Helen R. Warren Lynda M. Rose Germaine C. Verwoert Jouke‐Jan Hottenga Rona J. Strawbridge Tõnu Esko Dan E. Arking Shih-Jen Hwang Xiuqing Guo Zoltán Kutalik Stella Trompet Nick Shrine Alexander Teumer Janina S. Ried Joshua C. Bis Albert V. Smith Najaf Amin Ilja M. Nolte Leo‐Pekka Lyytikäinen Anubha Mahajan Nicholas J. Wareham Edith Hofer Peter K. Joshi Kati Kristiansson Michela Traglia Aki S. Havulinna Anuj Goel Mike A. Nalls Siim Sõber Dragana Vuckovic Jian’an Luan Fabiola Del Greco M Kristin L. Ayers Jaume Marrugat Daniela Ruggiero Lorna M. Lopez Teemu Niiranen Stefan Enroth Anne Jackson Christopher P. Nelson Jennifer E. Huffman Weihua Zhang Jonathan Marten Ilaria Gandin Sarah E. Harris Tatijana Zemunik Yingchang Lu Εvangelos Εvangelou Nabi Shah Martin H. de Borst Massimo Mangino Bram P. Prins Archie Campbell Ruifang Li‐Gao Ganesh Chauhan Christopher Oldmeadow Gonçalo Abecasis Maryam Abedi Caterina Barbieri Michael R. Barnes Chiara Batini John Beilby Tineka Blake Michael Boehnke Erwin P. Böttinger Peter S. Braund Morris J. Brown Marco Brumat Harry Campbell John C. Chambers Massimiliano Cocca Francis S. Collins John Connell Heather J. Cordell Jeffrey Damman Gail Davies Eco J. C. de Geus Renée de Mutsert Joris Deelen Yusuf Demirkale Alex S. F. Doney Marcus Dörr Martin Farrall Teresa Ferreira Mattias Frånberg He Gao Vilmantas Giedraitis Christian Gieger Franco Giulianini Alan J. Gow Anders Hamsten Tamara B. Harris

Elevated blood pressure is a major risk factor for cardiovascular disease and has substantial genetic contribution. Genetic variation influencing the potential to identify new pharmacological targets treatment of hypertension. To discover additional novel loci, we used 1000 Genomes Project–based imputation in 150 134 European ancestry individuals sought significant evidence independent replication further 228 245 individuals. We report 6 signals association or near HSPB7 , TNXB LRP12...

10.1161/hypertensionaha.117.09438 article EN Hypertension 2017-07-25
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