Lorna M. Lopez
- Genetic Associations and Epidemiology
- Alzheimer's disease research and treatments
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Bioinformatics and Genomic Networks
- Genomic variations and chromosomal abnormalities
- Cognitive Abilities and Testing
- Birth, Development, and Health
- Health, Environment, Cognitive Aging
- Advanced Neuroimaging Techniques and Applications
- Tryptophan and brain disorders
- Diet and metabolism studies
- Hormonal Regulation and Hypertension
- Nutrition, Genetics, and Disease
- Folate and B Vitamins Research
- Neurological Disease Mechanisms and Treatments
- Autism Spectrum Disorder Research
- Genomics and Rare Diseases
- Dementia and Cognitive Impairment Research
- Bipolar Disorder and Treatment
- Neuroscience and Neuropharmacology Research
- Gout, Hyperuricemia, Uric Acid
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Amyotrophic Lateral Sclerosis Research
- Blood Coagulation and Thrombosis Mechanisms
University of Pittsburgh
2011-2025
National University of Ireland, Maynooth
2020-2024
University Health Network
2014-2023
Trinity College Dublin
2019-2021
Institute of Molecular Medicine
2019
University of Edinburgh
2009-2018
Beaumont Hospital
2015-2018
Royal College of Surgeons in Ireland
2014-2018
University College Dublin
2015-2017
Royal College of Surgeons of England
2017
Background Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought identify new genes, using an alternative gene-wide analytical approach tests patterns of association within in the powerful genome-wide dataset International Genomics Project Consortium, comprising over 7 m genotypes from 25,580 cases and 48,466 controls. Principal Findings In addition...
Background— The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings incompletely characterized. To identify novel variants influencing burden, we conducted a meta-analysis multiethnic genome-wide association studies. Methods Results— We included 21 079 middle-aged to elderly individuals from 29 population-based cohorts, who were free dementia stroke European (n=17...
Elevated blood pressure is a major risk factor for cardiovascular disease and has substantial genetic contribution. Genetic variation influencing the potential to identify new pharmacological targets treatment of hypertension. To discover additional novel loci, we used 1000 Genomes Project–based imputation in 150 134 European ancestry individuals sought significant evidence independent replication further 228 245 individuals. We report 6 signals association or near HSPB7 , TNXB LRP12...