A5084400223- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Hospital Admissions and Outcomes
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Delphi Technique in Research
- Healthcare cost, quality, practices
- Chronic Disease Management Strategies
- School Health and Nursing Education
- Healthcare Operations and Scheduling Optimization
- Pneumonia and Respiratory Infections
- Emergency and Acute Care Studies
- Cardiovascular and exercise physiology
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Patient Safety and Medication Errors
- Sepsis Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Policy and Management
- Allergic Rhinitis and Sensitization
- Respiratory viral infections research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Tracheal and airway disorders
- Palliative Care and End-of-Life Issues
Curtin University
2019-2025
Sir Charles Gairdner Hospital
2018-2025
The University of Western Australia
2022-2024
Institute for Respiratory Health
2024
Tees, Esk and Wear Valleys NHS Foundation Trust
2021-2022
University of Liverpool
2013-2019
Royal Liverpool University Hospital
2016-2019
Aintree University Hospitals NHS Foundation Trust
2013-2018
Liverpool School of Tropical Medicine
2013-2018
Royal Liverpool and Broadgreen University Hospital NHS Trust
2017-2018
### The role of pulmonary rehabilitation ### Referral and assessment patients for rehabilitation #### Specific situations at assessment ##### Smoking
Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel variants associated with asthma, see whether previously identified for all types of contribute and provide mechanistic insights using expression analyses in patients asthma.In this genome-wide association study, we used a two-stage case-control design. In stage 1, genotyped patient-level data from two UK cohorts (the Genetics Asthma Severity Phenotypes [GASP] initiative the Unbiased BIOmarkers...
<h3>Background</h3> The genetic basis for developing asthma has been extensively studied. However, association studies to date have mostly focused on mild moderate disease and risk factors severe remain unclear. <h3>Objective</h3> To identify common variants affecting susceptibility asthma. <h3>Methods</h3> A genome-wide study was undertaken in 933 European ancestry individuals with based Global Initiative Asthma (GINA) criteria 3 or above 3346 clean controls. After standard quality control...
Genomic loci are associated with FEV1 or the ratio of to FVC in population samples, but their association chronic obstructive pulmonary disease (COPD) has not yet been proven, nor have combined effects on lung function and COPD studied.To test variants at five (TNS1, GSTCD, HTR4, AGER, THSD4) evaluate joint these single-nucleotide polymorphisms (SNPs), previously reported locus near HHIP.By sampling from 12 population-based studies (n = 31,422), we obtained genotype data 3,284 case subjects...
Aims Thiazide diuretics have a number of well‐documented metabolic adverse effects. The aim this study was to estimate the frequency hyponatraemia and hypokalaemia amongst patients taking thiazide diuretic in primary care. Methods A computerized search electronic prescribing laboratory records six UK general practices performed. Of 32 218 adult identified, 3773 had received at least one prescription for between years 1990 2002. Results Detailed data were available 2942 whom 951 (32.3%)...
<h3>Background</h3> Pulmonary rehabilitation (PR) improves exercise capacity and health status in patients with COPD, but many assessed for PR do not complete therapy. It is unknown whether socioeconomic deprivation associates rates of completion or the magnitude clinical benefits bequeathed by PR. <h3>Methods</h3> services across England Wales enrolled to National audit 2015. Deprivation was using Index Multiple (IMD) derived from postcodes. Study outcomes were therapy change measures...
Lymphangioleiomyomatosis is a rare disease occurring almost exclusively in women. Diagnosis often requires surgical biopsy and the clinical course varies between patients with no predictors of progression. We evaluated recent diagnostic guidelines, features serum biomarkers as prognostic tools.Serum vascular endothelial growth factor-D (VEGF-D), angiotensin converting enzyme (ACE), matrix metalloproteinases (MMP) -2 -9, phenotype, thoracic abdominal computerised tomography, lung function...
Abstract Objectives: In the United States thyroidectomy is a frequently performed surgery by both general and head neck surgeons. Even most experienced thyroid surgeon, however, has probably received pathology report stating that an incidental parathyroid gland or tissue was found in submitted specimen. The aim of this to explore some pathologic clinical characteristics unintentional parathyroidectomy during thyroidectomy. Study Design: A retrospective review thyroidectomies at University...
Purpose: Oral corticosteroids (OCS) are an effective treatment for severe uncontrolled asthma or exacerbations, but frequent bursts long-term use carry serious and sometimes irreversible adverse effects, complications such as adrenal insufficiency upon discontinuation. Our aim was to survey people with on their experiences of, attitudes towards, using OCS. Patients Methods: This study a national descriptive cross-sectional of in Australia. An anonymous hosted online invitations participate...
Asthma is a common and complex syndrome, major cause of morbidity healthcare costs. Clinicians have an array evidence-based investigations effective interventions at their disposal, but outcomes not improved as much trial evidence would suggest they could. This article discusses drivers behind this discrepancy using illustrative examples to highlight information gaps barriers that impair the delivery community emergency asthma care appropriate referral specialist services. It highlights...
The latest update to the NICE/BTS/SIGN guideline on chronic asthma care confronts us think about how we diagnose asthma, and therefore what actually is. document advises 'Do not confirm a diagnosis of without suggestive clinical history supporting objective test. Code as suspected until is confirmed.' [1] Given high rate misdiagnosis [2], large number other issues that can cause episodic breathlessness, cough, noisy breathing or chest tightness, this simple message should be contentious....
Abstract Background Many chronic conditions, such as epilepsy and asthma, are typified by recurrent events—repeated acute deterioration events of a similar type. Statistical models for these conditions often focus on evaluating the time to first event. They therefore do not make use data available all events. exist, but it is clear how best evaluate their performance. We compare relative performance statistical analysing asthma. Methods studied two clinical exemplars common infrequent...
<h3>Objective:</h3> The aim of this study was to estimate the contribution polymorphisms in positionally cloned asthma candidate genes <i>ADAM33, PHF11, DPP10, GPRA</i> and <i>PTGDR</i> risk asthma, total specific immunoglobulin E level, lung function wheezing a large, nationally representative, population. <h3>Methods:</h3> An association analysis undertaken using genotype data for tagging previously associated single nucleotide (SNPs) regions these longitudinal phenotype from singletons...