Renal angiomyolipomas are a frequent manifestation of tuberous sclerosis and sporadic lymphangioleiomyomatosis (LAM). These disorders associated with mutations TSC1 or TSC2 that lead to overactivation mTOR complex 1 (mTORC1), suggesting an opportunity for targeted therapy by using mTORC1 inhibitors. This study investigated the efficacy safety inhibitor sirolimus treatment renal in patients these disorders.In this multicenter phase 2 nonrandomized open label trial, 16 LAM angiomyolipoma(s)...

Percutaneous transthoracic lung biopsies are commonly performed for the investigation of masses. We describe current practice and complication rates in UK. A postal questionnaire was sent to all centres British Thoracic Society directory. 157 replies (61% response rate) were received, providing data on 5444 biopsies. Mean number per annum 30.5 centre; 8% did not perform biopsies, 36% <25 annum, 34% <50, 16% <100 6% >100. Consultant radiologists 91% Written consent obtained at centres. The...

<h3>Background</h3> Laboratory studies suggest that the clotting cascade is activated in fibrotic lungs. Since humans vary their tendency to clot due a variety of inherited or acquired defects, we investigated whether prothrombotic state increases chance developing idiopathic pulmonary fibrosis (IPF) and/or worsens prognosis IPF. <h3>Methods</h3> We recruited 211 incident cases IPF and 256 age- sex-matched general population controls collected data on medical history, medication, smoking...

Lymphangioleiomyomatosis is a rare disease occurring almost exclusively in women. Diagnosis often requires surgical biopsy and the clinical course varies between patients with no predictors of progression. We evaluated recent diagnostic guidelines, features serum biomarkers as prognostic tools.Serum vascular endothelial growth factor-D (VEGF-D), angiotensin converting enzyme (ACE), matrix metalloproteinases (MMP) -2 -9, phenotype, thoracic abdominal computerised tomography, lung function...

Background. The purpose of this study was to describe the prevalence and extent coronary artery calcification (CAC) in subjects with chronic kidney disease (CKD) stages 3 4 comparing those without diabetes. We also wished determine if presence peripheral (PAC) would assist identifying patients positive for CAC. Methods. CAC detected by multi-slice computed tomography PAC plain foot radiography. Study population 112 patients, 54 diabetes 58 without, all asymptomatic heart disease. Demographic...

Background Rare cystic lung diseases are increasingly recognised due the wider application of CT scanning making disease management a growing part respiratory care. Cystic tend to have extrapulmonary features that can both be diagnostic but also require surveillance and treatment in their own right. As some these now specific treatments, precise diagnosis is crucial. While Langerhans cell histiocytosis, Birt-Hogg-Dubé syndrome, lymphoid interstitial pneumonia lymphangioleiomyomatosis...

Metastatic pulmonary calcification occurs in association with several disease processes and has a highly variable prognosis. In certain patients, it may prove fatal, therefore prompt recognition of radiological signs is helpful for optimising patient management. We describe the progressive changes seen on CT 59-year-old man who had undergone renal transplant subsequently developed metastatic calcification. The merits different imaging techniques available possible treatment options are reviewed.

Background. The purpose of this study was to report the evolution coronary artery calcification (CAC) in subjects with chronic kidney disease Stages 3 and 4 comparing those without diabetes. We previously reported prevalence same population.

Abstract Background and objective Adult patients with chronic productive cough of unknown cause are commonly seen in respiratory clinics. We have previously described a subgroup these who short‐lived response to standard antibiotic treatment but prolonged 3 months low‐dose azithromycin therapy. Methods This observational study describes the physiological, radiological pathological features this patient cohort along their 12‐week open‐label trial 250 mg thrice weekly. Results A total 30...

To determine whether there is a survival benefit from open-lung-preserving surgery (radical decortication) for malignant mesothelioma, when compared with the non-radical approach in mesothelioma and radical (MARS)-trial era.We outcomes between 13 patients who underwent decortication (group RD, n = 13) case-matched patients, had palliative (NRD), over period of 2 years June 2006 onwards. Patients were matched age, sex, histology, computed tomography (CT) stage, haematological indices, body...

Pure invasive lobular carcinoma is more difficult to diagnose clinically and mammographically than other breast carcinomas. Our objective was document the ultrasound appearances of pure carcinoma, determine whether there were any specific features when compared similar cases ductal compare sensitivity with mammography in diagnosis carcinoma. We report on 23 who matched for age presentation High frequency detected lesions 22 all had highly suggestive malignancy. Twenty-one also malignant...

Solitary pulmonary nodule (SPN) is a common clinical problem, and the history vital in assessing pre-test probability of malignancy. Previous relevant imaging should be accessed. CT scanning for an SPN to defined protocol, so that any follow-up studies are comparable. Positron emission tomograpy depreotide both offer non-invasive characterization, which, with improved image registration, could use even nodules than 10 mm diameter.

The use of cross-sectional imaging in clinical medicine has been a major step forward the management many conditions but with that comes increasing demand on resources and detection other potentially significant findings. This, context shortage skilled radiologists, means new ways working are important. In thoracic CT, pulmonary nodules challenge because they so common. Poor inconsistent can both cause harm to patients waste it is important latest guidelines followed. latter mandate...

Cardiac magnetic resonance imaging (CMRI) has a varied clinical application in many cardiac disease processes, including pericardial and thoracic abnormalities. Anatomical functional information can be assessed monitored using CMRI, complex congenital heart vessel follow-up. Ischaemic quantitatively measured, areas of myocardium identified that may benefit from surgical reperfusion. Future advances CMRI should increase spatial resolution, which allow CMR coronary angiography. an increasingly...

<h3>Background</h3> The aetiology of idiopathic pulmonary fibrosis (IPF) remains poorly understood. Recent animal studies and epidemiological data have suggested that activation the coagulation cascade in lung may an important role pathogenesis IPF. <h3>Methods</h3> We recruited incident cases physician diagnosed IPF from five teaching hospitals eight district general England Wales. Age sex matched population controls were same region. Participants asked for details lifetime occupational...

<h3>BACKGROUND AND PURPOSE:</h3> Chest CT is a rapid, useful additional screening tool for coronavirus disease 2019 (COVID-19) in emergent procedures. We describe the feasibility and interim outcome of implementing modified imaging algorithm COVID-19 risk stratification across regional network primary stroke centers work-up acute ischemic referrals time-critical mechanical thrombectomy. <h3>MATERIALS METHODS:</h3> undertook retrospective review 49 patients referred to neuroscience unit...

Recent reports have suggested that atrial fibrillation (AF) is more prevalent in the large vessel occlusion (LVO) subgroup of acute ischaemic stroke patients. Given association between left enlargement (LAE) and AF, we sought to evaluate feasibility assessing LAE on non-gated CT its with LVO hyperacute setting.We analysed our prospectively collected database included all patients referred for consideration endovascular treatment April 14, 2020, May 21, 2020. During this period, a chest was...

<h3>Background</h3> We have previously demonstrated that people with idiopathic pulmonary fibrosis (IPF) are more likely to a prothrombotic state and IPF higher risk of death at year’s follow up. The aim this study was establish the impact clotting abnormalities on natural history respect median survival lung function (forced vital capacity (FVC)). <h3>Methods</h3> recruited 211 incident cases radiologically diagnosed definite or probable collected longitudinal information tests done as part...

<h3>Background</h3> Our previous case-control study demonstrated that a prothrombotic state was almost five times more common in people with idiopathic pulmonary fibrosis (IPF) than general population controls. We followed up the incident cases of IPF to determine if altered prognosis terms survival. <h3>Methods</h3> People were recruited from teaching and eight district hospitals England Wales. All participants asked for details medical history, medication smoking habit. Venous blood...