A5026734876- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Stroke Rehabilitation and Recovery
- Dementia and Cognitive Impairment Research
- Cardiovascular Health and Risk Factors
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Genetic Associations and Epidemiology
- Nutritional Studies and Diet
- Cardiac Imaging and Diagnostics
- Neurological Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Atrial Fibrillation Management and Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Sleep and related disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Health, Environment, Cognitive Aging
- Lipoproteins and Cardiovascular Health
- Retinal Imaging and Analysis
University of Miami
2016-2025
University of South Florida
2016-2025
Columbia University
2013-2024
Columbia University Irving Medical Center
2004-2024
McKnight Brain Research Foundation
2023-2024
Miller College
2023-2024
Sorbonne University Abu Dhabi
2024
Sorbonne Université
2024
Miami University
2017-2024
University of Miami Health System
2017-2024
Intima-media thickness (IMT) provides a surrogate end point of cardiovascular outcomes in clinical trials evaluating the efficacy risk factor modification. Carotid artery plaque further adds to assessment. It is defined as focal structure that encroaches into arterial lumen at least 0.5 mm or 50% surrounding IMT value demonstrates >1.5 measured from media-adventitia interface intima-lumen interface. The scientific basis for use and practice includes ultrasound physics, technical...
Intima-media thickness (IMT) is increasingly used as a surrogate end point of vascular outcomes in clinical trials aimed at determining the success interventions that lower risk factors for atherosclerosis and associated diseases (stroke, myocardial infarction peripheral artery diseases). The necessity to promote further criteria distinguish early atherosclerotic plaque formation from thickening IMT standardize measurements expressed through this updated consensus. Plaque defined focal...
Background— Stroke incidence is greater in blacks than whites; data on Hispanics are limited. Comparing subtype-specific ischemic stroke rates may help to explain race-ethnic differences risk. The aim of this population-based study was determine subtype for whites, blacks, and living one community. Methods Results— A comprehensive surveillance system incorporating multiple overlapping strategies used identify all cases first occurring between July 1, 1993, June 30, 1997, northern Manhattan....
Background— Chronic infections, including periodontal may predispose to cardiovascular disease. We investigated the relationship between microbiota and subclinical atherosclerosis. Methods Results— Of 1056 persons (age 69±9 years) with no history of stroke or myocardial infarction enrolled in Oral Infections Vascular Disease Epidemiology Study (INVEST), we analyzed 657 dentate subjects. Among these subjects, 4561 subgingival plaque samples were collected (average 7 samples/subject)...
The American Heart Association makes every effort to avoid any actual or potential
Chronic infections, including periodontal may predispose to cardiovascular disease. The present study investigates the relationship of disease and tooth loss with subclinical atherosclerosis.We enrolled 711 subjects a mean age 66+/-9 years no history stroke or myocardial infarction in Oral Infections Vascular Disease Epidemiology Study. Subjects received comprehensive examination, extensive in-person risk factor measurements, carotid scan using high-resolution B-mode ultrasound. Regression...
Background— Evidence of the relationship cardiovascular health (CVH), defined by American Heart Association, and specific outcomes is lacking, particularly among Hispanics. This study sought to evaluate between number ideal CVH metrics risk, overall event subtype, in a multiethnic community-based prospective cohort. Methods Results— A total 2981 subjects (mean age, 69±10 years; 54% Caribbean Hispanic, 25% black, 21% white) free myocardial infarction stroke at baseline Northern Manhattan...
Carotid atherosclerosis is a known biomarker associated with future vascular disease. The risk small, nonstenotic carotid plaques less clear. objective of this study was to examine the association between maximum plaque thickness and events in an urban multiethnic cohort.
Background and Purpose— Diabetes increases stroke risk, but whether diabetes status immediately before improves prediction duration is important are less clear. We hypothesized that independently predicts ischemic stroke. Methods— Among 3298 stroke-free participants in the Northern Manhattan Study, baseline age at diagnosis were determined. Incident was assessed annually (median, 9 years). Cox proportional hazard models used to estimate ratios (HR) 95% CI for incident using diabetes, as a...
Vascular cognitive impairment (VCI) is predominately caused by vascular risk factors and cerebrovascular disease. VCI includes a broad spectrum of disorders, from mild to dementia ischemic or hemorrhagic stroke, alone in combination with neurodegeneration including Alzheimer's disease (AD) AD-related dementia. accounts for at least 20-40% all diagnosis. Growing evidence indicates that pathology the most important contributor dementia, additive synergistic interactions neurodegenerative...
Background and Purpose- An excess incidence of strokes among blacks versus whites has been shown, but data on disparities related to Hispanic ethnicity remain limited. This study examines race/ethnic differences in stroke the multiethnic, largely Caribbean Hispanic, NOMAS (Northern Manhattan Study), whether vary by age. Methods- The population included participants prospective population-based NOMAS, followed for a mean 14±7 years. Multivariable-adjusted Cox proportional hazards models were...
Abstract Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause stroke and dementia. Genome-wide association studies in up to 40,095 participants (18 population-based cohorts, 66.3 ± 8.6 yr, 96.9% European ancestry) revealed 24 genome-wide significant PVS risk loci, mainly the white matter. These were associated with matter already young adults ( N = 1,748; 22.1 2.3 yr) enriched early-onset...
Background and Purpose —Although the cause of stroke among patients with patent foramen ovale (PFO) may be due to paradoxical cerebral embolism (PCE), this mechanism is often difficult prove. The aim our study was evaluate association between brain imaging findings suggestive PFO ischemic patients. Methods —As part Northern Manhattan Stroke Study, 95 first over age 39 underwent transesophageal echocardiography (TEE) for evaluation a cardiac source embolism. subtype determined by modified...
To assess the relationship between social isolation and stroke outcomes in a multiethnic cohort.As part of Northern Manhattan Stroke Study, authors prospectively followed cohort patients with for 5 years. Baseline data including were collected. At follow-up, documented outcome events as defined by first occurrence myocardial infarction (MI), recurrence, or death. Cox hazard models used to calculate ratio (HR, 95% CI) prestroke predictors post outcomes.The 655 ischemic cases mean The was 55%...