Aaron L. Goldman
A5034235981- Genetic Associations and Epidemiology
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
- Advanced MRI Techniques and Applications
- Schizophrenia research and treatment
- Machine Learning in Healthcare
- Nerve injury and regeneration
- Genomic variations and chromosomal abnormalities
- Bipolar Disorder and Treatment
- RNA Research and Splicing
- Diet and metabolism studies
- Birth, Development, and Health
- Congenital heart defects research
- European history and politics
- World Wars: History, Literature, and Impact
- RNA modifications and cancer
- Stress Responses and Cortisol
- Autism Spectrum Disorder Research
- Genomics and Chromatin Dynamics
- Neurobiology and Insect Physiology Research
- Developmental Biology and Gene Regulation
- Mental Health Research Topics
Lieber Institute for Brain Development
2015-2024
Hospital for Sick Children
2007-2024
University of Toronto
2007-2024
Johns Hopkins Medicine
2020-2024
Johns Hopkins University
2020-2024
Ames National Laboratory
2017
National Institute of Mental Health
2007-2016
National Institutes of Health
2007-2016
Yale University
2005-2009
Canada Research Chairs
2007-2008
Context: Schizophrenia is a brain disorder with predominantly genetic risk factors, and previous research has identified heritable cortical subcortical reductions in local volume.To our knowledge, thickness, measure of particular interest schizophrenia, not previously been evaluated terms its heritability relationship to for schizophrenia.Objective: To quantify the distribution thickness changes schizophrenia. Design:We analyzed large sample normal controls, affected patients, unaffected...
Abstract We compare three widely used brain volumetry methods available in the software packages FSL, SPM5, and FreeSurfer evaluate their performance using simulated real MR data sets. analyze accuracy of gray white matter volume measurements robustness against changes image quality BrainWeb MRI database. These images are based on “gold‐standard” reference templates. This allows us to assess between‐ (same set, different method) also within‐segmenter method, variation quality) comparability,...
High-resolution three-dimensional magnetic resonance imaging (3D-MRI) is being increasingly used to delineate morphological changes underlying neuropsychiatric disorders. Unfortunately, artifacts frequently compromise the utility of 3D-MRI yielding irreproducible results, from both type I and II errors. It therefore critical screen 3D-MRIs for before use. Currently, quality assessment involves slice-wise visual inspection volumes, a procedure that subjective time consuming. Automating rating...
Alterations in fMRI-based brain functional network connectivity (FNC) are associated with schizophrenia (SCZ) and the genetic risk or subthreshold clinical symptoms preceding onset of SCZ, which often occurs early adulthood. Thus, age-sensitive FNC changes may be relevant to SCZ risk-related FNC. We used independent component analysis estimate from childhood adulthood 9,236 individuals. To capture individual features more accurately than single-session fMRI, we studied an average three fMRI...
The cerebral cortex underlies our complex cognitive capabilities, yet we know little about the specific genetic loci influencing human cortical structure. To identify variants, including structural impacting structure, conducted a genome-wide association meta-analysis of brain MRI data from 51,662 individuals. We analysed surface area and average thickness whole 34 regions with known functional specialisations. identified 255 nominally significant ( P ≤ 5 × 10 −8 ); 199 survived multiple...
The polygenic architecture of schizophrenia implicates several molecular pathways involved in synaptic function. However, it is unclear how risk funnels through these to translate into syndromic illness. Using tensor decomposition, we analyze gene co-expression the caudate nucleus, hippocampus, and dorsolateral prefrontal cortex post-mortem brain samples from 358 individuals. We identify a set genes predominantly expressed nucleus associated with both clinical state genetic for that shows...
Little is known about how individual olfactory receptor neurons (ORNs) select, from among many odor genes, which genes to express. Abnormal chemosensory jump 6 (Acj6) a POU domain transcription factor essential for the specification of ORN identity and ( Or ) gene expression in Drosophila maxillary palp, one two adult organs. However, mechanism by Acj6 functions this process has not been investigated. Here, we systematically examine role palp major subset antennal ORNs. We define an binding...
Posttraumatic stress disorder (PTSD) follows exposure to a traumatic event in susceptible individuals. Recently, genome‐wide association studies have identified number of genetic sequence variants that are associated with the risk developing PTSD. To follow up on identifying molecular mechanisms these variants, we performed genotype RNA sequencing–derived quantitative expression (whole gene, exon, and exon junction levels) analysis dorsolateral prefrontal cortex (DLPFC) normal postmortem...
Imagine a young man in his home, going about life. Suddenly, there is knock at the door, and sheriff's deputy has come to take him mental health facility without notice or an opportuni...