A5014537649- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Parasitic infections in humans and animals
- Congenital Anomalies and Fetal Surgery
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurobiology and Insect Physiology Research
- Amoebic Infections and Treatments
- Herpesvirus Infections and Treatments
- Muscle Physiology and Disorders
- Ubiquitin and proteasome pathways
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Liver Disease Diagnosis and Treatment
- Visual Attention and Saliency Detection
- Mitochondrial Function and Pathology
- interferon and immune responses
- Biochemical and Structural Characterization
- SARS-CoV-2 and COVID-19 Research
- Plant responses to water stress
- Photoreceptor and optogenetics research
- Plant Stress Responses and Tolerance
- Endoplasmic Reticulum Stress and Disease
- Histiocytic Disorders and Treatments
- Advanced Image Fusion Techniques
- Peptidase Inhibition and Analysis
Soochow University
2024-2025
First Affiliated Hospital of Soochow University
2024-2025
Zhejiang University
2008-2024
Wuhan University
2018-2024
Anhui Science and Technology University
2024
Anhui University of Science and Technology
2024
Shanghai Artificial Intelligence Laboratory
2024
First Affiliated Hospital Zhejiang University
2020-2023
Xinjiang Medical University
2011-2022
First Affiliated Hospital of Xinjiang Medical University
2011-2021
Dimethyl sulfoxide (DMSO) is a polar organic solvent that used to dissolve neuroprotective or neurotoxic agents in neuroscience research. However, DMSO itself also has pharmacological and pathological effects on the nervous system. Astrocytes play central role maintaining brain homeostasis, but effect mechanism of astrocytes not been studied. The present study showed exposure astrocyte cultures 1% for 24 h did significantly affect cell survival, decreased viability glial glutamate...
Significance It is widely presumed that there a relationship between sleep and the gut microbiome because both restriction dysbiosis of are associated with metabolic diseases such as obesity diabetes. Here, we report over several consecutive days does not overtly influence composition either rats or humans, despite species showing other changes loss. These analyses suggest loss microbial have independent effects on development diseases.
Kaposi’s sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA virus with the capacity to establish life-long latent infection. During infection, viral genome persists as circular episome that associates cellular histones and exists nonintegrated minichromosome in nucleus of infected cells. Chromatin structure epigenetic programming are required for proper control gene expression stable maintenance DNA. However, there still limited knowledge regarding how host regulates chromatin...
Abstract Whether and how innate antiviral response is regulated by humoral metabolism remains enigmatic. We show that viral infection induces progesterone via the hypothalamic-pituitary-adrenal axis in mice. Progesterone downstream genes promotes cells mice, whereas knockout of receptor PGR has opposite effects. Mechanistically, stimulation activates tyrosine kinase SRC, which phosphorylates transcriptional factor IRF3 at Y107, leading to its activation induction genes. SARS-CoV-2-infected...
Kaposi’s sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA virus etiologically associated with multiple malignancies. Both latency and sporadic lytic reactivation contribute to KSHV-associated malignancies, however, the specific roles of many KSHV gene products in replication remain elusive. In this study, we report that ablation ORF55, late encoding tegument protein, does not impact but significantly reduces production progeny virions. We found cysteine 10 11 (C10 C11) pORF55...
Loss of the Neurofibromatosis 1 (Nf1) protein, neurofibromin, in Drosophila disrupts circadian rhythms locomotor activity without impairing central clock function, suggesting effects downstream clock. However, relevant cellular mechanisms are not known. Leveraging discovery output circuits for rhythms, we dissected actions neurofibromin recently identified substrates. Herein, show that affects levels and cycling calcium multiple peptidergic neurons. A prominent site action is pars...
The neuromuscular junction (NMJ) is a synapse between motoneurons and skeletal muscles to control motor behavior. Unlike extensively investigated postsynaptic differentiation, less known about mechanisms of presynaptic assembly. Genetic evidence Wnt in mammalian NMJ development was missing due the existence multiple Wnts their receptors. We show when secretion abolished from by mutating ligand mediator (Wls) gene, mutant mice showed muscle weakness neurotransmission impairment. NMJs were...
Circadian rhythms allow animals to coordinate behavioral and physiological processes with respect one another synchronize these external environmental cycles. In most animals, circadian are produced by core clock neurons in the brain that generate transmit time-of-day signals downstream tissues, driving overt rhythms. The neuronal pathways controlling outputs, however, not well understood. Furthermore, it is unclear how central modulates multiple distinct outputs. Identifying cellular...
Expansion of the hexanucleotide repeat GGGGCC in C9orf72 gene is most common genetic factor amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Poly-Gly-Ala (poly-GA), one form dipeptide proteins (DPRs) produced from repeats, tends to neurotoxic protein aggregates. The repeats microglial receptor TREM2 are both associated with risk for ALS/FTD. role regulation C9orf72-ALS/FTD remain unclear. Here, we found that poly-GA activate NLRP3 inflammasome produce interleukin-1β...
The activity of plasma membrane (PM) nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and its catalytic properties in rice was investigated under drought stress conditions. Drought led to decreased leaf relative water content (RWC) and, as a result drought-induced oxidative stress, the activities antioxidant enzymes increased significantly. More interestingly, intensity applied correlated with production H2O2 O2 (-) elevated PM NADPH oxidase, key enzyme reactive oxygen species...
Though evidence is mounting that a major function of sleep to maintain brain plasticity and consolidate memory, little known about the molecular pathways by which learning processes intercept. Anaplastic lymphoma kinase (Alk), gene encoding tyrosine receptor whose inadvertent activation cause many cancers, implicated in synapse formation cognitive functions. In particular, Alk genetically interacts with Neurofibromatosis 1 (Nf1) regulate growth associative flies. We show mutants have...
AIM:To evaluate the reliability and accuracy of threedimensional (3D) reconstruction for liver resection in patients with hepatic alveolar echinococcosis (HAE). METHODS:One-hundred six consecutive HAE underwent hepatectomy at our hospital between May 2011 January 2015.Fifty-nine preoperative 3D "virtual" before surgery (Group A).Another 47 used conventional imaging methods assessment B).Outcomes were compared two groups. RESULTS:There was no significant difference data groups.Compared Group...
The neuromuscular junction (NMJ) is a synapse between motoneurons and skeletal muscles to control motor behavior. Acetylcholine receptors (AChRs) are restricted at the synaptic region for proper neurotransmission. Mutations in mitochondrial CHCHD10 protein have been identified multiple disorders; however, physiological roles of NMJs remain elusive. Here, we report that highly expressed postsynapse muscles. Muscle conditional knockout mice showed defects, abnormal transmission NMJ structure....
Deubiquitinases (DUBs) remove ubiquitin from substrates and play crucial roles in diverse biological processes. However, our understanding of deubiquitination viral replication remains limited. Employing an oncogenic human herpesvirus Kaposi’s sarcoma-associated (KSHV) to probe the role protein deubiquitination, we found that Ovarian tumor family deubiquitinase 4 (OTUD4) promotes KSHV reactivation. OTUD4 interacts with transcription activator (K-RTA), a key factor controls reactivation,...
The scientific research paradigm is undergoing a profound transformation owing to the development of Artificial Intelligence (AI). Recent works demonstrate that various AI-assisted methods can largely improve efficiency by improving data analysis, accelerating computation, and fostering novel idea generation. To further move towards ultimate goal (i.e., automatic research), in this paper, we propose Dolphin, first closed-loop open-ended auto-research framework build entire process human...
Despite the availability of various antiepileptic treatments, approximately 30 % epilepsy patients remain refractory to conventional therapies, underscoring need for neuroprotective strategies. This study investigates role GrpEL1 in modulating mitochondrial unfolded protein response (UPRmt) and its potential protective effects on hippocampal neurons following experimental status epilepticus (SE). The were assessed vivo using a Lithium-pilocarpine rat model SE vitro with glutamate-treated...
The past two years have witnessed the evolution of large language model (LLM)-based multi-agent systems from labor-intensive manual design to partial automation (\textit{e.g.}, prompt engineering, communication topology) and eventually fully automated design. However, existing agentic pipelines often lack LLM heterogeneity focus on single-objective performance optimization, limiting their potential combine weaker models for more customized cost-effective solutions. To address this challenge,...
Little is known about how individual olfactory receptor neurons (ORNs) select, from among many odor genes, which genes to express. Abnormal chemosensory jump 6 (Acj6) a POU domain transcription factor essential for the specification of ORN identity and ( Or ) gene expression in Drosophila maxillary palp, one two adult organs. However, mechanism by Acj6 functions this process has not been investigated. Here, we systematically examine role palp major subset antennal ORNs. We define an binding...