A5100976449- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion Transport and Channel Regulation
- Cerebrospinal fluid and hydrocephalus
- Neuroscience and Neuropharmacology Research
- Antioxidants, Aging, Portulaca oleracea
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Dementia and Cognitive Impairment Research
- Bone and Joint Diseases
- Electrolyte and hormonal disorders
- Biochemical effects in animals
- Mitochondrial Function and Pathology
- Genetics and Neurodevelopmental Disorders
- Mosquito-borne diseases and control
- Malaria Research and Control
- Histone Deacetylase Inhibitors Research
- Bone health and osteoporosis research
- Autophagy in Disease and Therapy
- Neonatal and fetal brain pathology
- Sirtuins and Resveratrol in Medicine
- Fetal and Pediatric Neurological Disorders
- Magnesium in Health and Disease
- Ion channel regulation and function
- Neurological Disease Mechanisms and Treatments
Guangzhou Medical University
2017-2024
Nanjing Medical University
2014-2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Sun Yat-sen University
2024
Zhongshan Hospital
2024
Zhongshan People's Hospital
2024
Second Affiliated Hospital of Guangzhou Medical University
2017-2024
Shenyang Agricultural University
2023
Nanjing Brain Hospital
2020-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Preventing or reducing amyloid-beta (Aβ) accumulation in the brain is an important therapeutic strategy for Alzheimer's disease (AD). Recent studies showed that water channel aquaporin-4 (AQP4) mediates soluble Aβ clearance from parenchyma along paravascular pathway. However direct evidence roles of AQP4 pathophysiology AD remains absent. Here, we reported deletion exacerbated cognitive deficits 12-moth old APP/PS1 mice, with increases accumulation, cerebral amyloid angiopathy and loss...
Dimethyl sulfoxide (DMSO) is a polar organic solvent that used to dissolve neuroprotective or neurotoxic agents in neuroscience research. However, DMSO itself also has pharmacological and pathological effects on the nervous system. Astrocytes play central role maintaining brain homeostasis, but effect mechanism of astrocytes not been studied. The present study showed exposure astrocyte cultures 1% for 24 h did significantly affect cell survival, decreased viability glial glutamate...
Soluble beta-amyloid (Aβ) can be cleared from the brain through various mechanisms including enzymatic degradation, glial cell phagocytosis, transport across blood-brain barrier, and glymphatic clearance. However, relative contribution of each clearance system their compensatory effects in delaying pathological process Alzheimer's disease (AD) are currently unknown.Fluorescent trace, immunofluorescence, Western blot analyses were performed to compare ability Aβ accumulation among 3-month-old...
The eye is closely connected to the brain, providing a unique window detect pathological changes in brain. In this study, we discovered β-amyloid (Aβ) deposits along ocular glymphatic system patients with Alzheimer’s disease (AD) and 5×FAD transgenic mouse model. Interestingly, Aβ from brain can flow into eyes optic nerve through cerebrospinal fluid (CSF), causing retinal degeneration. mainly observed sheath, neural axon, perivascular space, which might represent critical steps of...
Background Increasing evidence supports the role of microRNAs (miRNAs) in major depressive disorder (MDD), but pathophysiological mechanism remains elusive. Aims To explore microRNA-451a (miR-451a) pathology and behaviours depression. Methods Abnormal miRNAs such as miR-451a reported previously serum patients with MDD were screened then confirmed a mouse model depression induced by chronic restraint stress (CRS). Eight-week-old male C57BL/6 mice had overexpression medial prefrontal cortex...
Abstract USP25 encodes ubiquitin-specific protease 25, a key member of the deubiquitinating enzyme family that is involved in neural fate determination. Although abnormal expression Down's syndrome was reported previously, specific role human diseases has not been defined. In this study, we performed trio-based whole exome sequencing cohort 319 cases (families) with generalized epilepsy unknown aetiology. Five heterozygous variants, including two de novo and three co-segregated were...
Non-cognitive behavioral and psychological symptoms often occur in Alzheimer's disease (AD) patients mouse models, although the exact neuropathological mechanism remains elusive. Here, we report hyperactivity with significant inter-individual variability 4-month-old APP/PS1 mice. Pathological analysis revealed that intraneuronal accumulation of amyloid-β (Aβ), c-Fos expression glutamatergic neurons activation astrocytes were more evident frontal motor cortex hyperactive mice, compared to...
Background: Alzheimer's disease (AD) patients are often accompanied by depressive symptoms, but its underlying mechanism remains unclear.The present study aimed to explore the potential role of microRNAs in comorbidity AD and depression.Methods: The miRNAs associated with depression were screened from databases literature then confirmed cerebrospinal fluid (CSF) different ages transgenic APP/PS1 mice.AAV9-miR-451a-GFP was injected into medial prefrontal cortex (mPFC) mice at seven months,...
Astrocyte dysfunction is implicated in pathogenesis of certain neurological disorders including Alzheimer's disease (AD). A growing body evidence indicates that water channel aquaporin-4 (AQP4) a potential molecular target for the regulation astrocyte function. Recently, we reported AQP4 expression was increased hippocampus an AD mouse model established by long-term ovarian hormone deprivation combined with D-galactose (D-gal) exposure. However, pathophysiological roles and mechanisms...
Mechanism of DHA combined with RES in inhibition cancer cell migration by DLC1/TCTP/Cdc42 signaling.
Bmi-1, a polycomb transcriptional repressor, is implicated in cell cycle regulation and senescence. Its absence results generalized astrogliosis epilepsy during the postnatal development, but underlying mechanisms are poorly understood. Here, we demonstrate occurrence of oxidative stress brain four-week-old Bmi-1 null mice. The mice showed various hallmarks neurodegeneration including synaptic loss, axonal demyelination, reactive gliosis mitochondrial damage. Moreover, astroglial glutamate...
Schematic representation of resveratrol inducing DNA damage-mediated cancer cell senescence through the DLC1–DYRK1A–EGFR axis.
Previous studies reported that a subpopulation of mouse and rat trigeminal neurons express water channel aquaporin-1 (AQP1). In this study we make comparative investigation AQP1 localization in the human systems. Immunohistochemistry immunofluorescence results showed was localized to cytoplasm cell membrane some medium small-sized neurons. Additionally, found numerous peripheral axons humans mice. central root brain stem, specifically expressed astrocytes humans, but restricted nerve fibers...