A5100367590- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Advanced biosensing and bioanalysis techniques
- EEG and Brain-Computer Interfaces
- Advanced Polymer Synthesis and Characterization
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Hydrogels: synthesis, properties, applications
- Advanced Drug Delivery Systems
- Visual perception and processing mechanisms
- Nanoplatforms for cancer theranostics
- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Virus-based gene therapy research
- Advanced Memory and Neural Computing
- Dendrimers and Hyperbranched Polymers
- Photoreceptor and optogenetics research
- Mental Health Research Topics
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Neural and Behavioral Psychology Studies
- Supramolecular Self-Assembly in Materials
State Key Laboratory of Medicinal Chemical Biology
2024-2025
University of Minnesota
2014-2025
Ministry of Education
2025
Nankai University
2024-2025
Huazhong Agricultural University
2022-2025
Nanjing Drum Tower Hospital
2020-2025
Nanjing Brain Hospital
2012-2024
Nanjing Medical University
2011-2024
Texas Department of State Health Services
2024
The Second Affiliated Hospital of Bengbu Medical College
2017-2024
Injectable hyaluronic acid (HA) hydrogels cross-linked via disulfide bond are synthesized using a thiol−disulfide exchange reaction. The production of small-molecule reaction product, pyridine-2-thione, allows the hydrogel formation process to be monitored quantitatively in real-time by UV spectroscopy. Rheological tests show that formed within minutes at 37 °C. Mechanical properties and equilibrium swelling degree can controlled varying ratio HA pyridyl macro-cross-linker PEG-dithiol....
Despite the potential efficacy of immune checkpoint blockade for effective treatment cancer, this therapeutic modality is not generally curative, and only a fraction patients respond. Combination approaches provide strategies to target multiple antitumor pathways induce synergistic immunity. Here, multi-combination immunotherapy, including photothermal therapy (PTT), indoleamine-2,3-dioxygenase (IDO) inhibition, programmed cell death-ligand 1 (PD-L1) blockade, introduced inducing We designed...
Abstract The cGAS‐STING pathway represents a crucial DNA‐sensing mechanism that has shown promise as target for overcoming immunoresistance in solid tumors. Mn 2+ and Zn play roles innate immune sensing of cytosolic dsDNA, ultimately resulting the activation pathway. Unfortunately, efficient delivery these metal ions to cells remains challenge, limiting their effectiveness activating STING Herein, novel strategy based on nanoscale coordination polymer (NCP)/polymer nano‐hybrids is presented,...
A novel hybrid hydrogel system based on N-(2-hydroxypropyl)methacrylamide copolymers was proposed. It consisted of the hydrophilic polymer backbone and a pair oppositely charged peptide grafts. Two distinct pentaheptad peptides (CCE CCK) were anticipated to create dimerization motif serve as physical cross-linkers. Consequently, graft CCE−P CCK−P self-assembled into hydrogels in situ; process modulated by formation antiparallel heterodimeric coiled-coils. This approach possesses an advantage...
Preparation of galactose-functionalized, core crosslinked, and hepatoma-targeted multi-responsive nanogels for antitumor drug controlled release.
Reactive oxygen species (ROS)-responsive nanocapsules for cancer drug delivery were engineered from green tea polyphenol–metal networks.
Water pollution by heavy metal ions is a critical threat to public health. To remove the pollutants from large waterbodies, we have synthesized biocompatible, cost-effective, ion non-specific, and ethylenediaminetetraacetic acid (EDTA)-inspired polydentate hydrogel with exceptionally high adsorption capacity reusability. The was transamidation reaction between hydrolyzed polyacrylamide branched polyethylenimine (BPEI). mechanical strength of displayed an increasing trend wt % cross-linker...
Background Increasing evidence supports the role of microRNAs (miRNAs) in major depressive disorder (MDD), but pathophysiological mechanism remains elusive. Aims To explore microRNA-451a (miR-451a) pathology and behaviours depression. Methods Abnormal miRNAs such as miR-451a reported previously serum patients with MDD were screened then confirmed a mouse model depression induced by chronic restraint stress (CRS). Eight-week-old male C57BL/6 mice had overexpression medial prefrontal cortex...
A stepwise anticancer drug delivery system based on an injectable supramolecular hydrogel was presented. In this system, poly(ethylene glycol)-b-poly(acrylic acid) (PEG-b-PAA) block copolymer nanoparticles containing cisplatin were released by erosion of the hydrogels and then from exchanging with chloride ions. By mixing α-cyclodextrins (α-CDs) PEG-b-PAA micelles their PAA cores loaded in water, novel generated threading α-CDs onto PEG segments forming physical cross-links molecular...
DNA vaccine is a third generation type based on concepts and techniques of molecular biology. It can closely mimic live infections induce both antibody cell mediated immune responses thus has much potential for treating chronic viral infection cancer. How do we transport the to right target cells in lymphoid tissues organs? achieve high robust gene transfection efficiency while simultaneously inducing DC maturation antigen presentation? These questions pose significant challenges addressing...
The combination of an antigen and adjuvant has synergistic effects on immune response. Coadministration a granulocyte-macrophage colony-stimulating factor (GM-CSF) hydrogel delivery system will afford novel strategy for enhancement response because the dual role as vaccine carrier with sustained release platform recruiting dendritic cells (DCs). Herein, injectable poly(caprolactone)–poly(ethylene glycol)–poly(caprolactone) thermosensitive coencapsulating GM-CSF ovalbumin nanoparticles was...
BackgroundThe number of cases gonorrhoea in the USA and worldwide caused by Neisseria gonorrhoeae is increasing (555 608 reported US 2017, 87 million 2016). Many countries report declining vitro susceptibility azithromycin, which a concern because azithromycin ceftriaxone are recommended dual treatment many countries. We aimed to identify strain types associated with decreased azithromycin.MethodsWe did genomic analysis N isolates obtained Gonococcal Isolate Surveillance Project. Isolates...