A5101817574- Alzheimer's disease research and treatments
- Angiogenesis and VEGF in Cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Breast Implant and Reconstruction
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Reconstructive Surgery and Microvascular Techniques
- Melanoma and MAPK Pathways
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Reconstructive Facial Surgery Techniques
- Neonatal and fetal brain pathology
- Ocular Oncology and Treatments
- Breast Cancer Treatment Studies
- Cutaneous Melanoma Detection and Management
- Ubiquitin and proteasome pathways
- Computational Drug Discovery Methods
- Neurogenesis and neuroplasticity mechanisms
- Mesenchymal stem cell research
- Dermatologic Treatments and Research
- Tissue Engineering and Regenerative Medicine
Nanjing Medical University
2010-2025
Nanjing Brain Hospital
2020-2025
Jiangsu Province Hospital
2010-2024
Walker (United States)
2021
Beijing Hospital
2020
Suzhou Municipal Hospital
2019
Hangzhou Cancer Hospital
2017
Shanghai Jiao Tong University
2010
Second Military Medical University
2010
Uveal melanoma(UVM) is the most common intraocular malignancy and has a poor prognosis. The clinical significance of necroptosis(NCPS) in UVM unclear.
Hepatocellular carcinoma (HCC) is one of the most common cancers in world and often associated with a poor prognosis. The main reason for this prognosis that inconspicuous early symptoms lead to delayed diagnosis. Treatment options advanced HCC remain limited ineffective. In context, exploration immune microenvironment becomes attractive. study, we divided into cell non-immune subtypes, by single-cell sequencing analysis GEO dataset GSE146115. We found differentially expressed genes two...
To construct a prognosis model of melanoma based on pyroptosis related genes.Melanoma RNA-sequencing data was downloaded from TCGA. First, the lnRNAs to were obtained through Pearson correlation analysis. Then, genes constructed by Cox regression and Lasso regression. Melanoma patients divided into high-risk low-risk groups risk score, differences in immune microenvironment between two explored.We found that group had significantly poorer prognosis, different differed infiltration, m6A...
Background The pathophysiology of keloid formation is not yet understood, so the identification biomarkers for kelod can be one step towards designing new targeting therapies which will improve outcomes patients with keloids or at risk developing keloids. Methods In this study, we performed single-cell RNA sequencing analysis, weighted co-expression network and differential expression analysis based on public databases. And 3 data from in our center were used validation. Besides, QRT-PCR...
Non-cognitive behavioral and psychological symptoms often occur in Alzheimer's disease (AD) patients mouse models, although the exact neuropathological mechanism remains elusive. Here, we report hyperactivity with significant inter-individual variability 4-month-old APP/PS1 mice. Pathological analysis revealed that intraneuronal accumulation of amyloid-β (Aβ), c-Fos expression glutamatergic neurons activation astrocytes were more evident frontal motor cortex hyperactive mice, compared to...
Background: Alzheimer's disease (AD) patients are often accompanied by depressive symptoms, but its underlying mechanism remains unclear.The present study aimed to explore the potential role of microRNAs in comorbidity AD and depression.Methods: The miRNAs associated with depression were screened from databases literature then confirmed cerebrospinal fluid (CSF) different ages transgenic APP/PS1 mice.AAV9-miR-451a-GFP was injected into medial prefrontal cortex (mPFC) mice at seven months,...
Varicella-zoster virus (VZV) central nervous system infection is typically observed in immunocompromised patients, and there a lack of studies involving large samples non-immunocompromised individuals. In this study, we retrospectively analyzed 108 patients diagnosed with VZV infection. This retrospective study was conducted the Department Neurology, Affiliated Nanjing Brain Hospital, Medical University, China. Metagenomic next-generation sequencing (mNGS) cerebrospinal fluid (CSF) revealed...
The major cause of cancer mortality is the metastatic spread tumor cells that can occur via multiple routes, including vascular system and lymphatic system. In this study, we developed an IgG-like fusion protein molecule [vascular endothelial growth factor (VEGF) receptor 31-immunoglobulin (VEGFR31-Ig)] which could simultaneously bind angiogenic VEGF-A lymphangiogenic VEGF-C. Importantly, VEGFR31-Ig exhibited VEGF-A-binding affinity similar to VEGFTrap, most potent binder, VEGF-C-binding...
Introduction Visual hallucination is a prevalent psychiatric disorder characterized by the occurrence of false visual perceptions due to misinterpretation in brain. Individuals with Parkinson’s disease often experience both minor and complex hallucinations. The underlying mechanism hallucinations patients commonly attributed dysfunction pathway attention network. However, there limited research on Methods To address this gap, we conducted an experiment involving 13 hallucinations, without...
Melanoma is a type of cancer with relatively poor prognosis. The development immunotherapy for the treatment patients melanoma has drawn considerable attention in recent years. It great clinical significance to identify novel promising prognostic biomarkers and explore their roles immune microenvironment. solute carrier (SLC) superfamily group transporters predominantly expressed on cell membrane are involved substance transport. SLC16A1 member SLC family, participating transport lactate,...
Metabolic reprogramming is common in various cancers. Targeting metabolism to treat tumors a hot research topic at present. Among them, changes glucose cancer have been widely studied. The Warburg effect maintains high metabolic level the tumor, accompanied by transporters. transmembrane transport of sugar was previously thought be mediated SGLT and GLUT. Recently, Solute Carrier Family(SLC) 45 family may third transporter. But role value SLC45 melanoma, highly malignant skin unclear. Our...
Currently, the role of liquid-liquid phase separation (LLPS) in cancer has been preliminarily explained. However, significance LLPS breast is unclear. In this study, single cell sequencing datasets GSE188600 and GSE198745 for were downloaded from GEO database. Transcriptome data UCSC We divided cells into high-LLPS group low-LLPS by down dimension clustering analysis single-cell set, obtained differentially expressed genes between two groups. Subsequently, weighted co-expression network...
Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis, with high mortality no proven therapy. Here, we reported severe uremic calciphylaxis patient progressive skin ischemia, large areas of painful malodorous ulcers, mummified legs. Because the worsening symptoms signs refractory to conventional therapies, treatment human amnion-derived mesenchymal stem cells (hAMSCs) was approved. Preclinical release inspections hAMSCs, efficacy,...
Uveal melanoma is a highly malignant tumor in the eye. Its recurrence and metastasis are common, prognosis poor.The transcriptome data of UVM were downloaded from TCGA database, single cell sequencing dataset GSE139829 was GEO database. Weighted co-expression network analysis used to explore modules associated with m7G. Lasso regression construct M7G-related prognostic signature. Immune infiltration significance model immune microenvironment. Finally, assays function key genes MUM-2B OCM-1...
Background: The fractional amplitude of low-frequency fluctuations (fALFFs) can detect spontaneous brain activity. However, the association between abnormal activity and cognitive function, amyloid protein (Aβ), emotion in Alzheimer’s disease (AD) patients remains unclear. Objective: This study aimed to survey alterations fALFF different frequency bands relationship activity, depressive mood, function determine potential mechanism AD. Methods: We enrolled 34 AD 32 healthy controls (HC). All...
Introduction Available patient-reported outcome (PRO) studies are mainly from single institution or of small sample size, and the variations across hospitals regions were not fully analysed. A multicentre, prospective, outcome-reconstruction oncoplastic cohort (PRO-ROC) will be planned to assess PROs Chinese patients with breast cancer who undergo reconstruction (BR) breast-conserving surgery (OBCS). Methods analysis The inclusion criteria female aged >18 years old BR OBCS. This include...
Keloid is a disease that seriously affects the aesthetic appearance of body. In contrast to normal skin or hypertrophic scars, keloid tissue extends beyond initial site injury. Patients may complain pain, itching, burning. Although multiple treatments exist, none uniformly successful. Genetic advances have made it possible explore differences in gene expression between keloids and skin. Identifying biomarker for beneficial mechanism exploration treatment development keloid. this study, we...
Plakophilins (PKPs) act as a key regulator of different signaling programs and control variety cellular processes ranging from transcription, protein synthesis, growth, proliferation, tumor development. The function possible mechanism PKP3 in ovarian cancer (OC) remain unknown. It is extremely important to investigate the expression prognostic values PKP3, well their mechanisms, immune infiltration OC. Therefore, this paper we explored potential oncogenic role 33 tumors based on Cancer...
Background: Platelet proteins may be associated with Alzheimer’s disease (AD) pathology. Objective: To investigate the relationship between platelet and cerebrospinal fluid (CSF) biomarkers of AD cognition in individuals memory decline to identify effective screening methods for detecting early stages disease. Methods: We classified 68 participants subjective according ATN framework determined by CSF amyloid-β (A), p-tau (T), t-tau (N). All underwent Mini-Mental State Examination (MMSE)...