A5100744575- Breast Cancer Treatment Studies
- AI in cancer detection
- Global Cancer Incidence and Screening
- Cancer Genomics and Diagnostics
- Breast Lesions and Carcinomas
- HER2/EGFR in Cancer Research
- Breast Implant and Reconstruction
- Cancer and Skin Lesions
- Cancer Treatment and Pharmacology
- Mass Spectrometry Techniques and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Digital Radiography and Breast Imaging
- Cancer survivorship and care
- BRCA gene mutations in cancer
- Endometrial and Cervical Cancer Treatments
- Hedgehog Signaling Pathway Studies
- Cytokine Signaling Pathways and Interactions
- Neuroendocrine Tumor Research Advances
- Reconstructive Facial Surgery Techniques
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Infrared Thermography in Medicine
- Cancer Risks and Factors
- Anesthesia and Neurotoxicity Research
- Genomic variations and chromosomal abnormalities
Fudan University Shanghai Cancer Center
2006-2024
Shanghai Medical College of Fudan University
2008-2024
Fudan University
2020
University of Virginia
1999-2001
Abstract As a cell proliferation biomarker, Ki-67 is principally used in ER+/HER2− breast cancer. However, the importance and best cutoff point of triple-negative cancer (TNBC) remains unclear was evaluated this study.A total 1800 patients with early invasive TNBC between 2011 2016 at Fudan University Shanghai Cancer Center were consecutively recruited for study. The optimal assessed by Cutoff Finder. Propensity score matching (PSM, ratio = 1:2) performed to match low group high group....
Abstract To better understand the molecular mechanisms underlying breast cancer metastasis and search for potential markers metastatic progression, we have developed a highly variant of human MDA‐MB‐435 cell line through in vivo stepwise selection pulmonary cells caused by parental athymic mice. Comparative proteomic analysis using 2‐DE LC‐IT‐MS revealed that 102 protein spots were reproducibly altered more than three‐fold between selected its counterpart. Eleven differentially expressed...
It has been reported that triple negative phenotype is characterized by aggressive clinical history in Western breast cancer patients, however its pattern of metastatic spread had never the Chinese population. Considering racial disparities, we sought to analyze for different sites first recurrence cancers.A retrospective study 1662 patients was carried out from a large database undergoing surgery between January 1, 2000 and March 31, 2004 at Cancer Hospital, Fudan University, Shanghai,...
To determine the histopathological and MRI features of BRCA1/2 mutation-associated familial breast cancers compared with those mutation-negative sporadic to further compare imaging from BRCA1 BRCA2 mutation carriers according lesion type on MRI.A retrospective review medical records was conducted tumour clinicopathologic characteristics between June 2011 July 2017, 93 lesions BRCA mutations, without mutations were included. Histopathologic data, including immunohistochemistry findings data...
Sclerosing adenosis (SA) is a less common histopathological lesion of the breast that can coexist with proliferative lesions as well malignancies. We aimed to analyze clinicopathological characteristics SA and investigate radiological features SA. Patients who underwent surgery at our institute from 2007 2013 were retrospectively reviewed. A total 815 breasts (722 patients) included in final analysis. Synchronous bilateral was defined detection another arising contralateral within 1 month...
Introduction Available patient-reported outcome (PRO) studies are mainly from single institution or of small sample size, and the variations across hospitals regions were not fully analysed. A multicentre, prospective, outcome-reconstruction oncoplastic cohort (PRO-ROC) will be planned to assess PROs Chinese patients with breast cancer who undergo reconstruction (BR) breast-conserving surgery (OBCS). Methods analysis The inclusion criteria female aged >18 years old BR OBCS. This include...
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Abstract Purpose Previous studies provide inconsistent interpretations of the effect inherited genetic factors on survival and prognosis patients with breast cancer. The aim this study was to examine germline BRCA1 BRCA2 mutation subsequent events in Chinese women who underwent breast‐conserving surgery. Methods A retrospective review clinical pathological records performed diagnosed primary invasive cancer between 2005 2018 registry database. Clinicopathological data regarding treatment...
Characteristics of mammographic density for Chinese women are understudied. This study aims to identify factors associated with in China using a quantitative method. Mammographic was measured total 1071 (84 and 987 without breast cancer) an automatic algorithm AutoDensity. Pearson tests examined relationships between continuous variables t-tests compared differences mean values groupings categorical variables. Linear models were built multiple regression. Percentage dense area positively...
Lymphedema and psychological distress, including anxiety depression, are common in breast cancer patients post-surgery. This study aimed to assess the incidence determinants of depression with acute lymphedema (ALE) following surgery.
We describe the use of direct multiple least‐squares fitting (unfiltered) biological X‐ray spectra. Test this method on computer‐generated spectra and experimental specimens shows that, for average specimen, improves precision Ca measurements by an approximate factor 1.6 a given electron dose. The influence non‐statistical, instrumental sources measurement errors is considered, we show simple reducing effect these error in directly fitted
Considering the rapid rise in breast cancer incidence China and lack of calibrated prediction models for Chinese female population, developing a model targeting women is necessary. This study aimed at generating risk women. A total 1079 (85 images contralateral to 994 cases without cancer) were recruited from Fudan University Shanghai Cancer Centre. For each case, we collected sixteen demographic variables such as age, BMI, number children, family history cancer, age menarche. Moreover,...
Abstract Background. The proliferation factor Ki67 is prognostic but determination methods differ. Their reproducibility and independent value largely unknown. Aim. To evaluate the of different assessment compare their with Mitotic Activity Index (MAI), Phosphohistone-3 (PPH3) other prognosticators. Methods. In 240 T1,2N0M0 breast cancers without systemic adjuvant treatment, standardized automated quantitative immunohistochemistry was used for Ki7 PPH3 a strictly formalized protocol MAI...